Results 51 to 60 of about 5,920 (201)

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

The roles of microtubule-based transport at presynaptic nerve terminals

Frontiers in Synaptic Neuroscience, 2016
Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins is mediated by motor complexes travelling along intracellular
Oleksandr eYagensky, Tahere eKalantary Dehaghi, John Jia En eChua, John Jia En eChua, John Jia En eChua   +4 more
doaj   +1 more source

Axonemal Growth and Alignment During Paraspermatogenesis in the Marine Gastropod Strombus luhuanus

Frontiers in Cell and Developmental Biology, 2022
Parasperm are non-fertilizing sperm that are produced simultaneously with fertile eusperm. They occur in several animal species and show considerable morphological diversity.
Daisuke Shibata, Masaya Morita, Yu Sato, Kogiku Shiba, Seiya Kitanobo, Ryo Yokoya, Kazuo Inaba   +6 more
doaj   +1 more source

Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing

, 2015
Much like vertebrate hair cells, the chordotonal sensory neurons that mediate hearing in Drosophila are motile and amplify the mechanical input of the ear.
Schon, Michael A., Eberl, Daniel F., Katana, Radoslaw, Spalthoff, Christian, Sivan-Loukianova, Elena, Kernan, Maurice J., Göpfert, Martin C., Jacobs, Julie S., Kittelmann, Maike, Karak, Somdatta   +9 more
core   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Axonemal Beta Heavy Chain Dynein DNAH9: cDNA Sequence, Genomic Structure, and Investigation of Its Role in Primary Ciliary Dyskinesia [PDF]

, 2001
Dyneins are multisubunit protein complexes that couple ATPase activity with conformational changes. They are involved in the cytoplasmatic movement of organelles (cytoplasmic dyneins) and the bending of cilia and flagella (axonemal dyneins), Here we ...
Rossier, C, Jorissen, M., Bartoloni, Lucia, She, J. X., Marron, M. P., Armengot, M., Meeks, M., Sainsbury, A., She, J-X, Blouin, Jean-Louis, Chung, E., Gardiner, R. M., Delozier-Blanchet, CD, Jorissen, M, Sainsbury, Amanda, Delozier-Blanchet, C. D., Meeks, M, Blouin, J-L, Scott, Hamish Steele, Rossier, Colette, Antonarakis, Stylianos, Maiti, AK, Antonarakis, SE, Gehrig, C, Maiti, A. K., Chung, E, Armengot, M, Gardiner, RM, Marron, MP, Lander, E. S., Bartoloni, L, Lander, ES, Scott, HS, Gehrig, Corinne, Scott HS, Delozier-Blanchet CD, Jorissen M, Maiti AK, Meeks M, Armengot M, Sainsbury A, Lander ES, Rossier C, Gardiner RM, She JX, Marron MP, Blouin JL, Bartoloni L, Antonarakis SE, Gehrig C, Chung E   +50 more
core   +1 more source

The Kinesin Speed Paradox Revisited: How Can Cargoes Move Faster Than Their Motors?

Cytoskeleton, EarlyView.
ABSTRACT Intracellular transport is essential for cellular organization and function. Kinesin‐1, the founding member of the kinesin superfamily, delivers a wide range of cargoes along microtubules. Since its discovery, extensive work has identified cargo–kinesin interactions and regulatory mechanisms.
Kanako Iwasaki, Yasushi Okada
wiley   +1 more source

Force-Generating Mechanism of Axonemal Dynein in Solo and Ensemble

, 2020
In eukaryotic cilia and flagella, various types of axonemal dyneins orchestrate their distinct functions to generate oscillatory bending of axonemes.
Kazuhiro Oiwa, Kenta Ishibashi, Hitoshi Sakakibara   +2 more
core   +1 more source