Results 71 to 80 of about 5,920 (201)
Lissencephaly-1 is a context-dependent regulator of the human dynein complex
eLife, 2017 The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach +6 more
doaj +1 more source
Protein Glutamylation: From Cytoskeleton to Signaling
Med Research, EarlyView.Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen +4 more
wiley +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng +3 more
wiley +1 more source
, 1989 Dynein is a large, complex microtubule mechanochemical translocator. Although discovered over 25 years ago in the axonemes of protozoa and sea urchin sperm flagella, relatively little is known about the structure and function of this important motor ...
Foltz, Kathleen Rae
core +1 more source
Simulated dynein sequestration by the microtubule spindle.
, 2012 (A) Time series of dynein distribution (also see Movie S1). Dyneins are initially randomly distributed throughout the cytoplasm. Dark grey lines: microtubules (only 1 out of 10 are shown to reduce clutter); blue dots: dyneins bound to microtubules; red ...
Jennifer Lippincott-Schwartz (171711) +2 more
core +1 more source
Spatial Gene Expression in Fungi: mRNA Localization, Condensates, and Beyond
Yeast, EarlyView.ABSTRACT Polarized growth and cellular asymmetry are broadly conserved properties of fungal life, from transient bud‐site selection in unicellular yeasts to sustained hyphal extension in filamentous and coenocytic species. While vesicle trafficking, cytoskeletal organization, and cell‐wall remodeling are well‐established contributors to these processes,
Sander van Otterdijk +3 more
wiley +1 more source
Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements
Cell Reports, 2014 Cargo transport along microtubules is driven by the collective function of microtubule plus- and minus-end-directed motors (kinesins and dyneins). How the velocity of cargo transport is driven by opposing teams of motors is still poorly understood. Here,
Max A. Schlager +7 more
doaj +1 more source
Huntingtin as an Actin Organizer: Structural and Functional Insights
Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
wiley +1 more source
Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species
Andrology, EarlyView.ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak +2 more
wiley +1 more source
Molecular adaptations allow dynein to generate large collective forces inside cells
, 2013 SummaryMany cellular processes require large forces that are generated collectively by multiple cytoskeletal motor proteins. Understanding how motors generate force as a team is therefore fundamentally important but is poorly understood.
Jha, Rupam +4 more
core +1 more source