Results 81 to 90 of about 5,920 (201)

Sperm Mitochondrial DNA Copy Number and Nuclear DNA Methylation Across Clinical and Non‐Clinical Preconception Cohorts

Andrology, EarlyView.
ABSTRACT Background Sperm mitochondrial DNA copy number is an emerging marker of male fertility, with elevated mtDNAcn associated with poor semen quality across various populations. Sperm DNA methylation has also been previously demonstrated to be negatively correlated with semen parameters in IVF cohorts.
Savni Sawant, Karolina Nowak, Amanda L. Paskavitz, Emily Houle, Ricardo P. Bertolla, Lidia Minguez‐Alarcon, Russ Hauser, J. Richard Pilsner   +7 more
wiley   +1 more source

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

Andrology, EarlyView.
ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni, Fiorella Di Nicuolo, Giorgia Mazzuccato, Alessandro Oliva, Emanuele Pierpaolo Vodola, Francesca Mancini, Carla Di Nardo, Edoardo Vergani, Michela Cicchinelli, Federica Iavarone, Cassandra Serantoni, Giuseppe Maulucci, Alessia Riente, Alfredo Pontecorvi, Andrea Urbani, Domenico Milardi, Silvia Baroni   +16 more
wiley   +1 more source

Registry alteration in Dynein's microtubule-binding domain: A AAA domain-guided event

Chemical Physics Impact
Dynein, a motor protein, harnesses chemical energy from ATP hydrolysis to generate mechanical output as it travels along microtubular tracks. Essential to this process is the microtubule-binding domain (MTBD), which facilitates the interaction with and ...
Pradipta Kumar Das, Biman Jana
doaj   +1 more source

A liquid-like organelle at the root of motile ciliopathy

eLife, 2018
Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus.
Ryan L Huizar, Chanjae Lee, Alexander A Boulgakov, Amjad Horani, Fan Tu, Edward M Marcotte, Steven L Brody, John B Wallingford   +7 more
doaj   +1 more source

Lactate‐Responsive Glycogen Dynamics Are Associated With Bull Sperm Motility and Fertilization Under Glucose‐Limited Conditions

Andrology, EarlyView.
ABSTRACT Background Mammalian sperm need to undergo hyperactivation, capacitation, and acrosome reaction to achieve fertilization competence. However, the female reproductive tract presents contrasting metabolic environments. The uterus is glucose‐rich, and the oviduct is lactate‐rich and glucose‐limited.
Md Faizul Hossain Miraz, Takahiro Yamanaka, Takashi Umehara, Shahrina Akter, Wambugu Enoc Njoroge, Masayuki Shimada   +5 more
wiley   +1 more source

Purification and characterization of Salmo gairdneri outer arm dynein

, 2008
Dyneins are multimeric ATPases, which make up the inner and outer arms that bridge the outer doublet microtubules of eukaryotic cilia and flagella. They are responsible for the generation of sliding between outer doublets, which in turn is the basis for ...
Moss, Anthony G., Witman, George B., Gatti, Jean-Luc, King, Stephen M.   +3 more
core   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Microtubule translocation properties of intact and proteolytically digested dyneins from Tetrahymena cilia. [PDF]

, 1989
Tetrahymena cilia contain a three-headed 22S (outer arm) dynein and a single-headed 14S dynein. In this study, we have employed an in vitro assay of microtubule translocation along dynein-coated glass surfaces to characterize the motile properties of 14S
R D Vale, Y Y Toyoshima, Vale, RD, Toyoshima, YY   +3 more
core   +1 more source

SlBPC1 regulates fruit elongation by directly repressing SlOFP2/SlOFP21 and SUN expression in tomato

Journal of Integrative Plant Biology, EarlyView.
In tomato, switching off the transcription factor gene SlBPC1 leads to longer fruits by altering cell division patterns during early fruit development. The SlBPC1 regulatory pathway includes the SlOFP2, SlOFP21, and SUN genes, offering valuable targets for breeding tomatoes with market‐preferred shapes.
Sunan Gao, Long Cui, Licheng Xiao, Rong Huang, Jing Wei, Chunrui Chen, Wenran Su, Jiajun Ran, Lei Song, Jingyi Li, Taotao Wang, Zonglie Hong, Zhibiao Ye, Jie Ye, Junhong Zhang   +14 more
wiley   +1 more source