Results 101 to 110 of about 5,717 (230)

A liquid-like organelle at the root of motile ciliopathy

eLife, 2018
Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus.
Ryan L Huizar, Chanjae Lee, Alexander A Boulgakov, Amjad Horani, Fan Tu, Edward M Marcotte, Steven L Brody, John B Wallingford   +7 more
doaj   +1 more source

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins

, 2008
Cilia and flagella are highly conserved organelles that have diverse roles in cell motility and sensing extracellular signals. Motility defects in cilia and flagella often result in primary ciliary dyskinesia.
Zhang, Qi, Hara, C., Mizuno, H., Mitchell, David R., Zhang, Q., Olbrich, H., Kobayashi, Daisuke, Mizuno, Hideaki, Miyawaki, Atsushi, Kamiya, R., Takeda, Hiroyuki, Watanabe, Yoshinori, O'Toole, Eileen, Kobayashi, D., Koshida, S., Zentgraf, Hanswalter, Omran, H., Hagiwara, H., Miyawaki, A., Tsukahara, Tatsuya, Reinhardt, Richard, Kawano, H., Fliegauf, Manfred, Koshida, Sumito, Mitchell, D., Tsukahara, T., Loges, Niki Tomas, Seithe, Horst, Omran, Heymut, Kawano, Hiroyuki, Olbrich, Heike, Reinhardt, R., Leblond, Gerard, Zentgraf, H., Seithe, H., Watanabe, Y., Kamiya, Ritsu, O'Toole, E., Loges, N., Loges, Niki T., Hara, Chikako, Leblond, G., Takeda, H., Hagiwara, Haruo, O'Toole, Eileen T., Yagi, Toshiki, Yagi, T., Fliegauf, M.   +47 more
core   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Simulated dynein sequestration by the microtubule spindle.

, 2012
(A) Time series of dynein distribution (also see Movie S1). Dyneins are initially randomly distributed throughout the cytoplasm. Dark grey lines: microtubules (only 1 out of 10 are shown to reduce clutter); blue dots: dyneins bound to microtubules; red ...
Jennifer Lippincott-Schwartz (171711), Jian Liu (33711), Jing Chen (4762)   +2 more
core   +1 more source

Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/ cytokinesis using RNA interference [PDF]

, 2005
Microtubule (MT)-based motor proteins, kinesins and dyneins, play important roles in multiple cellular processes including cell division. In this study, we describe the generation and use of an Escherichia coli RNase III-prepared human kinesin/dynein ...
Changjun Zhu, Jian Zhao, Joel D. Leverson, Wei Jiang, Jian-bing Fan, Robert T. Abraham, Marina Bibikova, Ella Bossy-wetzel   +7 more
core   +1 more source

Novel Postzygotic Variants Associated With Hypomelanosis of Ito Expand the ACTB‐Related Neurocutaneous Disease Spectrum

Clinical Genetics, EarlyView.
We describe a previously unreported phenotype related to postzygotic ACTB variants with hypomelanosis of Ito, characterized by hypopigmentation associated or not with neurodevelopmental features, distinct from Becker presentations, bridging constitutional neurodevelopmental and somatic cutaneous phenotypes.
Estella Castillon, Paul Rollier, Didier Bessis, Laurent Pasquier, Caroline Racine, Alexis Praga, Pierre Vabres, Bertille Bonniaud, Paul Kuentz, Laurence Faivre   +9 more
wiley   +1 more source

Huntingtin as an Actin Organizer: Structural and Functional Insights

Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
wiley   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Fine-tuning motile cilia and flagella: Evolution of the dynein motor proteins from plants to humans at high resolution. [PDF]

, 2016
The flagellum is a key innovation linked to eukaryogenesis. It provides motility by regulated cycles of bending and bend propagation, which are thought to be controlled by a complex arrangement of seven distinct dyneins in repeated patterns of outer-(OAD)
Kollmar, M., Kollmar, Martin
core   +1 more source

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source