Results 101 to 110 of about 5,920 (201)

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

TMEM55B Maintains Lysosomal Homeostasis and Promotes ER–Lysosome Calcium Signaling

Traffic, Volume 27, Issue 4, December 2026.
Hypothetical model: The lysosomal protein TMEM55B interacts with an ER protein complex containing Protrudin and PDZD8 at ER–lysosome membrane contact sites, and also acts to stabilize v‐ATPase in lysosomes. Through these interactions, TMEM55B contributes to the maintenance of luminal homeostasis, including lysosomal acidification and regulates ER ...
Nagi Mukae, Honoka Maki, Michiko Shirane
wiley   +1 more source

Structure and Function of Dynein’s Non-Catalytic Subunits

Cells
Dynein, an ancient microtubule-based motor protein, performs diverse cellular functions in nearly all eukaryotic cells, with the exception of land plants.
Lu Rao, Arne Gennerich
doaj   +1 more source

International Collaboration in Primary Ciliary Dyskinesia

Pediatric Pulmonology, Volume 61, Issue 11, November 2026.
ABSTRACT Primary Ciliary Dyskinesia (PCD) exemplifies how international collaboration can transform the study of a rare disease. Since the identification of the first PCD‐associated genes in 1999–2002, parallel developments in Europe and North America, driven by patient organizations, academic investigators, and coordinated funding initiatives, have ...
Petra Pennekamp, Michele Manion, Heymut Omran   +2 more
wiley   +1 more source

Biallelic Truncating Variant in LRGUK Is Associated With Severe Multiple Morphological Abnormalities of the Sperm Flagella and Sperm Nuclear Defects in Humans

Clinical Genetics, Volume 110, Issue 5, Page 538-548, November 2026.
A homozygous truncating variant in LRGUK results in loss of the LRGUK protein and causes multiple morphological abnormalities of the flagella (MMAF), disrupted axonemal architecture, central pair defects, abnormal chromatin organization, and severe male infertility, establishing LRGUK as a novel human infertility gene.
Wiâme Mokkedem, Zeina Wehbe, Anne‐Laure Barbotin, Angèle Boursier, Célia Tebbakh, Nicolas Thierry‐Mieg, Marie Bidart, Antonella Migliaccio, Rosanna Chianese, Christophe Arnoult, Raoudha Zouari, Zine‐Eddine Kherraf, Pierre F. Ray, Guillaume Martinez, Charles Coutton   +14 more
wiley   +1 more source

The Role of Actin‐Filament Bundling Protein, Fimbrin Sac6, and Type‐V Myosin Myo2, in the Motion of the SUN‐Domain Protein, Mps3, During Yeast Meiosis

Genes to Cells, Volume 31, Issue 6, November 2026.
Type‐V myosin (Myo2) promotes the motion of Mps3 patches on the nuclear membrane during yeast meiosis. On the other hand, Sac6 fimbrin, which bundles actin filaments, is not critical for the motion of Mps3, suggesting the role of a few actin filaments in the Mps3 motion.
Shuangping Cheng, Tadasu Nozaki, Yurika Fujita, Masaru Ito, Akira Shinohara   +4 more
wiley   +1 more source

PIH1D2 Loss‐of‐Function Directs Ciliary and Cell Cycle Defects Resulting in Left Isomerism With or Without Biliary Atresia

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims Laterality disorders are rare congenital conditions caused by disruption of left–right embryonic patterning, often associated with ciliary dysfunction. Despite the identification of numerous causative genes, the molecular basis remains unresolved in many patients.
Alina Kurolap, Chofit Chai Gadot, Adel Shalata, Orly Eshach Adiv, Yam Amir, Bar Levy Lando, Florian Stehling, Tova Hershkovitz, Khaled Osman, Clair Habib, Hila Mintz, Ran Steinberg, Amit Hochberg, Uri Hamiel, Adi Mory, Daphna Marom, Sandra von Hardenberg, Amihood Singer, Bernd Auber, Hagit Baris Feldman   +19 more
wiley   +1 more source

The Maternal Blood Transcriptome Reflects Molecular Signatures Associated With Large Offspring Syndrome and Other Adverse Pregnancy Outcomes in Cattle

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Blood samples from pregnant heifers carrying in vitro‐produced embryos were analyzed for RNA‐sequencing to test whether maternal blood transcriptome could be predictive of large offspring syndrome, stillbirth, and abortion compared with controls.
Tatiane S. Maia, Maria B. Rabaglino, Rebecca Krisher, Paula Rodriguez‐Villamil, Jeniffer Pamela J. Laguna, Jeniffer F. Escoto, Yanping Zhang, Abigail J. Sproull, Peter J. Hansen   +8 more
wiley   +1 more source

15-3-8 : 繊毛､鞭毛を規範としたアクチュエータの開発 [PDF]

Cilia and Eukaryotic flagella possess two singlet microtubules and nine outer doublet microtubules. Protuberances of protein named as dyneins, are placed along doublet microtubules.
小林, 俊一, 森川, 裕久
core   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, Volume 600, Issue 19, Page 2917-2928, October 2026.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source