Results 121 to 130 of about 5,920 (201)
C‐Terminal Tail Elongation Adds a New Dimension to the Tubulin Code
ABSTRACT Tubulin C‐terminal tails undergo diverse post‐translational modifications that regulate microtubule interactions with motors and severing enzymes. TTLL11, a member of the tubulin tyrosine ligase‐like (TTLL) family, uniquely catalyzes glutamate addition to the terminal α‐carboxyl group of both α‐ and β‐primary tubulin tails.
Jana Campbell, Cyril Barinka
wiley +1 more source
ABSTRACT The aim of this study was to characterize the proteome of sperm and seminal plasma (SP) from rams with high semen freezability (HF) and low semen freezability (LF). Eleven ejaculates were collected from 12 rams, at 3‐day intervals, and cryopreserved (132 semen samples).
Wallisson Bruno de Morais Pacheco +14 more
wiley +1 more source
Microtubule-associated cargo transport, a central process governing the localization and movement of various cellular cargoes, is orchestrated by the coordination of two types of motor proteins (kinesins and dyneins), along with diverse adaptor and ...
Hye Seon Lee +6 more
doaj +1 more source
Functional Analysis of Inner-Arm Dynein Knockdowns in Trypanosoma brucei [PDF]
African Trypanosomasis is an endemic disease in sub-Saharan Africa caused by infection with the Trypanosoma brucei parasite. These unicellular eukaryotic organisms rely heavily on their single flagellum for movement and proliferation.
Kinzel, Kathryn
core
Making the Diagnosis of Primary Ciliary Dyskinesia in Australia
ABSTRACT Background and Objective Primary Ciliary Dyskinesia (PCD) is a genetic disorder associated with recurrent infections and irreversible airway damage. No single diagnostic test exists, necessitating use of a diagnostic algorithm that varies internationally.
Michelle Cai +7 more
wiley +1 more source
Gene knockouts reveal separate functions for two cytoplasmic dyneins in Tetrahymena thermophila [PDF]
In many organisms, there are multiple isoforms of cytoplasmic dynein heavy chains, and division of labor among the isoforms would provide a mechanism to regulate dynein function.
Wisniewski, Julie C. +3 more
core
Variants in CEP135 Cause Congenital Microcephaly and Primary Ciliary Dyskinesia
ABSTRACT Introduction Primary ciliary dyskinesia (PCD), a disorder of motile ciliary dysfunction causing chronic respiratory infections, may also rarely present with aspects of non‐motile ciliary dysfunction, including retinitis, central nervous system malformations, skeletal dysplasia, and sensorineural hearing loss.
Abigail Bergman‐Sieger +8 more
wiley +1 more source
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu +2 more
wiley +1 more source
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang +11 more
wiley +1 more source

