Results 111 to 120 of about 5,920 (201)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, Volume 600, Issue 20, Page 3106-3129, October 2026.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo
Advanced Functional Materials, Volume 36, Issue 86, 26 October 2026.In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim +28 more
wiley +1 more source
Advanced Science, Volume 13, Issue 59, 23 October 2026.Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu +12 more
wiley +1 more source
ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites
Advanced Science, Volume 13, Issue 60, 28 October 2026.ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng +9 more
wiley +1 more source
Advanced ScienceMost Lepidopterans produce two distinct sperm types—nucleated eupyrene (fertile) and anucleate apyrene (non‐fertile), yet the genetic mechanisms governing this dimorphism remain poorly understood.
Hao Sun +5 more
doaj +1 more source
Proteomic Signatures of Noise‐Induced Hearing Loss in the Mouse Cochlea
Cell Biology International, Volume 50, Issue 10, October 2026.ABSTRACT Hearing loss affects over 1.5 billion people worldwide and has substantial social, educational, and economic consequences. Although genetic studies have identified numerous hearing‐loss‐associated genes, the molecular changes accompanying noise‐induced hearing loss (NIHL) remain incompletely understood.
Ana Carla Batissoco +6 more
wiley +1 more source
15-3-8 : 繊毛､鞭毛を規範としたアクチュエータの開発
, 2015 Cilia and Eukaryotic flagella possess two singlet microtubules and nine outer doublet microtubules. Protuberances of protein named as dyneins, are placed along doublet microtubules.
小林, 俊一, 森川, 裕久
core +1 more source
, 2014 CG31320/HEATR2 orthologues are found in species with cilia/flagella that have motile function and retain elements of the axonemal dyneins required for this motility. Species which have no cilia (ie.
Ian M. Carr (141801) +23 more
core +1 more source
Cytoskeleton, Volume 83, Issue 10, Page 779-794, October 2026.ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong +7 more
wiley +1 more source
Targeted dynein inhibition generates flagellar beating
, 2017 Motile cilia and flagella are highly conserved organelles that are essential for the normal development and health of many eukaryotes including humans. To reveal the molecular mechanism of motility, we used cryo-electron tomography of active sea urchin ...
Daniela Nicastro, Jianfeng Lin
core +1 more source