Results 131 to 140 of about 8,740 (224)

Genomic Analysis and Population Divergence Driven by Geographic Isolation in Neotetracus sinensis

Ecology and Evolution, Volume 16, Issue 4, April 2026.
We generated the first chromosome‐level reference genome for Neotetracus sinensis and resequenced populations from the Gaoligong and Wuliang Mountains to investigate divergence across the Hengduan “sky‐island” landscape. Genomic data reveal strong population structure with negligible gene flow and parallel demographic histories shaped by Pleistocene ...
Jianxuan Zhou, Nannan Chen, Weihao Dou, Zhonglai Luo, Libo Jiang, Meidong Jing, Fengtang Yang   +6 more
wiley   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Molecular basis for assembly and activation of the Hook3 − KIF1C complex-dependent transport machinery

EMBO Reports
Microtubule-associated cargo transport, a central process governing the localization and movement of various cellular cargoes, is orchestrated by the coordination of two types of motor proteins (kinesins and dyneins), along with diverse adaptor and ...
Hye Seon Lee, Daseuli Yu, Kyoung Eun Baek, Ho-Chul Shin, Seung Jun Kim, Won Do Heo, Bonsu Ku   +6 more
doaj   +1 more source

Adipose Tissue‐Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance

Obesity, Volume 34, Issue 4, Page 896-907, April 2026.
ABSTRACT Objective Glucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT‐derived small extracellular vesicles (sEVAT) change in response to glucose availability and differ by GT status.
Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang‐Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep   +10 more
wiley   +1 more source

The Diagnosis of Primary Ciliary Dyskinesia: Putting The European Respiratory/American Thoracic Guideline Into Practice

Pediatric Pulmonology, Volume 61, Issue 4, April 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a rare inherited disease which is characterised by progressive lung disease, chronic rhinosinusitis, repeated middle ear infections, laterality defects, and reduced fertility. An early diagnosis is critical to reduce morbidity, however diagnosis is often delayed due to the heterogeneity in clinical ...
Katharine Harman, Amjad Horani, Amelia Shoemark   +2 more
wiley   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Sequence and expression analysis of potential spermatogenesis‐specific gene cognates in the Caribbean fruit fly, Anastrepha suspensa

Insect Science, Volume 33, Issue 2, Page 505-516, April 2026.
Abstract The sterile insect technique (SIT) is a highly effective biologically‐based method for the suppression of many insect pest populations. SIT efficacy could be improved by methods of male sterilization that avoid the use of irradiation that can result in diminished fitness and mating competitiveness.
Alfred M. Handler, Richard B. Furlong, Chao Chen, Daniel A. Hahn   +3 more
wiley   +1 more source

Exploring the Neural Substrates of Number Sense: A Perspective on Genetics, Behaviour and Neural Circuity

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Numerical cognition arises from conserved mechanisms linking genes, neural circuits and behaviour. Using zebrafish as a tractable model, behavioural assays, whole‐brain imaging and genetic analyses can be integrated to identify neural and molecular bases of quantity discrimination. This framework provides a platform for studying numerical cognition and
Mirko Zanon, Caroline H. Brennan, Maria Elena Miletto Petrazzini, Jose V. Torres‐Pérez   +3 more
wiley   +1 more source

Adaptor-mediated recruitment of three dyneins to dynactin enhances force generation. [PDF]

Nat Cell Biol
Rao L, Liu X, Arnold M, Okada K, McKenney RJ, Stengel K, Sidoli S, Berger F, Gennerich A.   +8 more
europepmc   +1 more source