Results 91 to 100 of about 8,740 (224)

C‐Terminal Tail Elongation Adds a New Dimension to the Tubulin Code

Cytoskeleton, EarlyView.
ABSTRACT Tubulin C‐terminal tails undergo diverse post‐translational modifications that regulate microtubule interactions with motors and severing enzymes. TTLL11, a member of the tubulin tyrosine ligase‐like (TTLL) family, uniquely catalyzes glutamate addition to the terminal α‐carboxyl group of both α‐ and β‐primary tubulin tails.
Jana Campbell, Cyril Barinka
wiley   +1 more source

Intracellular transport driven by cytoskeletal motors: General mechanisms and defects

, 2015
Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large.
Appert-Rolland, Cecile, Ebbinghaus, Maximilian, Santen, Ludger   +2 more
core   +3 more sources

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

The preprophase band-associated kinesin-14 OsKCH2 is a processive minus-end-directed microtubule motor. [PDF]

, 2018
In animals and fungi, cytoplasmic dynein is a processive minus-end-directed motor that plays dominant roles in various intracellular processes. In contrast, land plants lack cytoplasmic dynein but contain many minus-end-directed kinesin-14s.
Bowen, Joel, Gicking, Allison M, Guo, Lijun, Lee, Yuh-Ru Julie, Liu, Bo, Qiu, Weihong, Tseng, Kuo-Fu, Wang, Pan   +7 more
core   +3 more sources

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements

Cell Reports, 2014
Cargo transport along microtubules is driven by the collective function of microtubule plus- and minus-end-directed motors (kinesins and dyneins). How the velocity of cargo transport is driven by opposing teams of motors is still poorly understood. Here,
Max A. Schlager, Andrea Serra-Marques, Ilya Grigoriev, Laura F. Gumy, Marta Esteves da Silva, Phebe S. Wulf, Anna Akhmanova, Casper C. Hoogenraad   +7 more
doaj   +1 more source

Tug-of-war of molecular motors: the effects of uneven load sharing

, 2011
We analyze theoretically the problem of cargo transport along microtubules by motors of two species with opposite polarities. We consider two different one-dimensional models previously developed in the literature.
Bouzat, Sebastian, Falo, Fernando
core   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Registry alteration in Dynein's microtubule-binding domain: A AAA domain-guided event

Chemical Physics Impact
Dynein, a motor protein, harnesses chemical energy from ATP hydrolysis to generate mechanical output as it travels along microtubular tracks. Essential to this process is the microtubule-binding domain (MTBD), which facilitates the interaction with and ...
Pradipta Kumar Das, Biman Jana
doaj   +1 more source