Results 21 to 30 of about 438,155 (307)

Kinesin-14 : the roots of reversal [PDF]

, 2010
Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross, R. A., Cross Robert A, Robert A Cross   +2 more
core   +1 more source

Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells

Molecular Oncology, 2023
Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa, Akira Matsura, Masaya Shimada, Sumire Ishida‐Ishihara, Fuyu Sato, Takahiro Yamamoto, Kan Yaguchi, Eiji Kawamoto, Taruho Kuroda, Kazuya Matsuo, Nobuyuki Tamaoki, Ryuichi Sakai, Yasuhito Shimada, Mithilesh Mishra, Ryota Uehara   +14 more
doaj   +1 more source

Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

eLife, 2022
The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions.
Wen Yan, Saad Ansari, Adam Lamson, Matthew A Glaser, Robert Blackwell, Meredith D Betterton, Michael Shelley   +6 more
doaj   +1 more source

In situ velocity control of gliding microtubules with temperature monitoring by fluorescence excitation on a patterned gold thin film

Materials Research Express, 2014
Microtubule (MT) gliding on a kinesin-coated surface is a promising nanoactuator to manipulate nanomaterials in microfluidic environments. However, controllability of motors with respect to velocity, direction, and lifetime has been challenging for ...
T Nakahara, J Ikuta, H Shintaku, H Kotera, R Yokokawa   +4 more
doaj   +1 more source

Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A

eLife, 2018
Motor and non-motor crosslinking proteins play critical roles in determining the size and stability of microtubule-based architectures. Currently, we have a limited understanding of how geometrical properties of microtubule arrays, in turn, regulate the ...
Sithara Wijeratne, Radhika Subramanian
doaj   +1 more source

Autoinhibited kinesin-1 adopts a hierarchical folding pattern

eLife, 2023
Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan, Yang Yue, Felipe Leprevost, Sarah Haynes, Venkatesha Basrur, Alexey I Nesvizhskii, Kristen J Verhey, Michael A Cianfrocco   +7 more
doaj   +1 more source

Experimental test of connector rotation during DNA packaging into bacteriophage phi29 capsids [PDF]

, 2007
The bacteriophage phi29 generates large forces to compact its double-stranded DNA genome into a protein capsid by means of a portal motor complex. Several mechanical models for the generation of these high forces by the motor complex predict coupling of ...
Hetherington, Craig L., Craig L Hetherington, Falk, Wayne, Wayne Falk, Thorsten Hugel, Jardine, Paul J., Falk Wayne, Hugel Thorsten, Bustamante, Carlos, Grimes Shelley, Michaelis, Jens, Walter Jessica M, Bustamante Carlos, Michaelis Jens, Anderson, Dwight L., Hugel, Thorsten, Grimes, Shelley, Paul J Jardine, Jessica M Walter, Walter, Jessica M., Jardine Paul J, Dwight L Anderson, Jens Michaelis, Anderson Dwight L, Carlos Bustamante, Hetherington Craig L, Shelley Grimes   +26 more
core   +1 more source

Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]

, 2009
Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Hazel P Williams, Greensmith Linda, Francesca Achilli, Ruth Chia, Elizabeth M. C. Fisher, Hazel P. Williams, Fisher Elizabeth M. C., Achilli, F., Chia, R, Bryson, J.B., Bros-Facer, V., Greensmith, L., Bros-Facer, V, Banks, G.T., Bryson, JB, Banks, GT, Fisher, EMC, Bros-Facer Virginie, Linda Greensmith, Fisher, E.M.C., Banks Gareth T., Chia, R., Gareth T Banks, Williams, HP, Greensmith, L, Williams Hazel P., Elizabeth M C Fisher, J Barney Bryson, Gareth T. Banks, Virginie Bros-Facer, Achilli Francesca, Williams, H.P., Bryson J. Barney, Chia Ruth, J. Barney Bryson, Achilli, F   +35 more
core   +1 more source

Structural snapshots of the kinesin‐2 OSM‐3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism

FEBS Open Bio, 2021
Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela, Mélanie Chenon, Christophe Velours, Kristen J. Verhey, Julie Ménétrey, Benoît Gigant   +5 more
doaj   +1 more source

GDNF signaling in subjects with minimal motor deficits and Parkinson's disease

Neurobiology of Disease, 2021
The failure of glial cell derived neurotropic factor to be efficacious in blinded clinical trials for Parkinson's disease may be due to alterations in signaling receptors and downstream signaling molecules.
Yaping Chu, Jeffrey H. Kordower
doaj   +1 more source