Results 21 to 30 of about 4,736,786 (299)
Materials Research Express, 2014 Microtubule (MT) gliding on a kinesin-coated surface is a promising nanoactuator to manipulate nanomaterials in microfluidic environments. However, controllability of motors with respect to velocity, direction, and lifetime has been challenging for ...
T Nakahara +4 more
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eLife, 2018 Motor and non-motor crosslinking proteins play critical roles in determining the size and stability of microtubule-based architectures. Currently, we have a limited understanding of how geometrical properties of microtubule arrays, in turn, regulate the ...
Sithara Wijeratne, Radhika Subramanian
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Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells
Molecular Oncology, 2023 Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa +14 more
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Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies
eLife, 2022 The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions.
Wen Yan +6 more
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Autoinhibited kinesin-1 adopts a hierarchical folding pattern
eLife, 2023 Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan +7 more
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FEBS Open Bio, 2021 Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela +5 more
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GDNF signaling in subjects with minimal motor deficits and Parkinson's disease
Neurobiology of Disease, 2021 The failure of glial cell derived neurotropic factor to be efficacious in blinded clinical trials for Parkinson's disease may be due to alterations in signaling receptors and downstream signaling molecules.
Yaping Chu, Jeffrey H. Kordower
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Motor Proteins: Myosin Mechanosensors [PDF]
Current Biology, 2008 Mechanosensation is emerging as a general principle of myosin motors. As demonstrated in a recent study, the single-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small force range.
Kee, Yee-Seir, Robinson, Douglas N.
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The mechanism of kinesin inhibition by kinesin-binding protein
eLife, 2020 Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution.
Joseph Atherton +8 more
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Journal of Biomechanical Science and Engineering, 2008 Kinesins, biomolecular motors moving along microtubules (MTs) in cells, can potentially be utilized as nano-scale transport systems with an inverted gliding assay, in which the MTs glide on a kinesin-coated surface.
Shukei SUGITA +3 more
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