Results 21 to 30 of about 4,636,911 (251)

Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

eLife, 2022
The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions.
Wen Yan, Saad Ansari, Adam Lamson, Matthew A Glaser, Robert Blackwell, Meredith D Betterton, Michael Shelley   +6 more
doaj   +1 more source

Autoinhibited kinesin-1 adopts a hierarchical folding pattern

eLife, 2023
Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan, Yang Yue, Felipe Leprevost, Sarah Haynes, Venkatesha Basrur, Alexey I Nesvizhskii, Kristen J Verhey, Michael A Cianfrocco   +7 more
doaj   +1 more source

Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction

New Journal of Physics, 2017
The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the collective behaviors of cytoskeletal networks emerge from the properties of the network’s constituent motor proteins and ...
Peter J Foster, Wen Yan, Sebastian Fürthauer, Michael J Shelley, Daniel J Needleman   +4 more
doaj   +1 more source

Force Dependence of Velocity and Run Length of Kinesin-1, Kinesin-2 and Kinesin-5 Family Molecular Motors

Molecules, 2019
Kinesin-1, kinesin-2 and kinesin-5 are three families of a superfamily of motor proteins; which can walk processively on microtubule filaments by hydrolyzing ATP. It was experimentally shown that while the three kinesin dimers show similar feature on the
Si-Kao Guo, Wei-Chi Wang, Peng-Ye Wang, Ping Xie   +3 more
doaj   +1 more source

cDNA that encodes active agrin [PDF]

, 1992
Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments,
Kröger, Stephan, Tsim, K. W., McMahan, U. J., Ruegg, M. A., Escher, G., Tsim, Karl W. K., Ruegg, Markus A., Escher, Gérard, Tsim, Karl W.K., Kroger, S.   +9 more
core   +1 more source

Structural snapshots of the kinesin‐2 OSM‐3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism

FEBS Open Bio, 2021
Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela, Mélanie Chenon, Christophe Velours, Kristen J. Verhey, Julie Ménétrey, Benoît Gigant   +5 more
doaj   +1 more source

GDNF signaling in subjects with minimal motor deficits and Parkinson's disease

Neurobiology of Disease, 2021
The failure of glial cell derived neurotropic factor to be efficacious in blinded clinical trials for Parkinson's disease may be due to alterations in signaling receptors and downstream signaling molecules.
Yaping Chu, Jeffrey H. Kordower
doaj   +1 more source

In situ velocity control of gliding microtubules with temperature monitoring by fluorescence excitation on a patterned gold thin film

Materials Research Express, 2014
Microtubule (MT) gliding on a kinesin-coated surface is a promising nanoactuator to manipulate nanomaterials in microfluidic environments. However, controllability of motors with respect to velocity, direction, and lifetime has been challenging for ...
T Nakahara, J Ikuta, H Shintaku, H Kotera, R Yokokawa   +4 more
doaj   +1 more source

The mechanism of kinesin inhibition by kinesin-binding protein

eLife, 2020
Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution.
Joseph Atherton, Jessica JA Hummel, Natacha Olieric, Julia Locke, Alejandro Peña, Steven S Rosenfeld, Michel O Steinmetz, Casper C Hoogenraad, Carolyn A Moores   +8 more
doaj   +1 more source

Motor Proteins: Myosin Mechanosensors [PDF]

Current Biology, 2008
Mechanosensation is emerging as a general principle of myosin motors. As demonstrated in a recent study, the single-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small force range.
Kee, Yee-Seir, Robinson, Douglas N.
openaire   +2 more sources