Results 21 to 30 of about 410,637 (261)
FEBS Open Bio, 2021 Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela +5 more
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GDNF signaling in subjects with minimal motor deficits and Parkinson's disease
Neurobiology of Disease, 2021 The failure of glial cell derived neurotropic factor to be efficacious in blinded clinical trials for Parkinson's disease may be due to alterations in signaling receptors and downstream signaling molecules.
Yaping Chu, Jeffrey H. Kordower
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The mechanism of kinesin inhibition by kinesin-binding protein
eLife, 2020 Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution.
Joseph Atherton +8 more
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Motor Proteins: Myosin Mechanosensors [PDF]
Current Biology, 2008 Mechanosensation is emerging as a general principle of myosin motors. As demonstrated in a recent study, the single-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small force range.
Kee, Yee-Seir, Robinson, Douglas N.
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Journal of Biomechanical Science and Engineering, 2008 Kinesins, biomolecular motors moving along microtubules (MTs) in cells, can potentially be utilized as nano-scale transport systems with an inverted gliding assay, in which the MTs glide on a kinesin-coated surface.
Shukei SUGITA +3 more
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Structures of kinesin motor proteins [PDF]
Cell Motility, 2009 AbstractAlmost 25 years of kinesin research have led to the accumulation of a large body of knowledge about this widespread superfamily of motor and nonmotor proteins present in all eukaryotic cells. This review covers developments in kinesin research with an emphasis on structural aspects obtained by X‐ray crystallography and cryoelectron microscopy 3‐
Marx, A., Hoenger, A., Mandelkow, E.
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New Journal of Physics, 2017 The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the collective behaviors of cytoskeletal networks emerge from the properties of the network’s constituent motor proteins and ...
Peter J Foster +4 more
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eLife, 2015 The size and position of mitotic spindles is determined by the lengths of their constituent microtubules. Regulation of microtubule length requires feedback to set the balance between growth and shrinkage.
Anneke Hibbel +7 more
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Kinesin motility is driven by subdomain dynamics
eLife, 2017 The microtubule (MT)-associated motor protein kinesin utilizes its conserved ATPase head to achieve diverse motility characteristics. Despite considerable knowledge about how its ATPase activity and MT binding are coupled to the motility cycle, the ...
Wonmuk Hwang +2 more
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eLife, 2014 The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear.
Alessandro Costa +9 more
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