Results 21 to 30 of about 717,772 (297)
Sunday Driver Mediates Multi-Compartment Golgi Outposts Defects Induced by Amyloid Precursor Protein
Frontiers in Neuroscience, 2021 Golgi defects including Golgi fragmentation are pathological features of Alzheimer’s disease (AD). As a pathogenic factor in AD, amyloid precursor protein (APP) induces Golgi fragmentation in the soma.
Qianqian Du +9 more
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Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]
, 2018 Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying +10 more
core +1 more source
Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells
Molecular Oncology, 2023 Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa +14 more
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Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies
eLife, 2022 The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions.
Wen Yan +6 more
doaj +1 more source
Modelling Molecular Motors as Folding-Unfolding Cycles [PDF]
, 1999 We propose a model for motor proteins based on a hierarchical Hamiltonian that we have previously introduced to describe protein folding. The proposed motor model has high efficiency and is consistent with a linear load-velocity response.
+8 more
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Materials Research Express, 2014 Microtubule (MT) gliding on a kinesin-coated surface is a promising nanoactuator to manipulate nanomaterials in microfluidic environments. However, controllability of motors with respect to velocity, direction, and lifetime has been challenging for ...
T Nakahara +4 more
doaj +1 more source
eLife, 2018 Motor and non-motor crosslinking proteins play critical roles in determining the size and stability of microtubule-based architectures. Currently, we have a limited understanding of how geometrical properties of microtubule arrays, in turn, regulate the ...
Sithara Wijeratne, Radhika Subramanian
doaj +1 more source
Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy [PDF]
, 2019 Distal hereditary motor neuropathies are a rare subgroup of inherited peripheral neuropathies hallmarked by a length-dependent axonal degeneration of lower motor neurons without significant involvement of sensory neurons.
Asselbergh, B +10 more
core +1 more source
Autoinhibited kinesin-1 adopts a hierarchical folding pattern
eLife, 2023 Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan +7 more
doaj +1 more source
The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance [PDF]
, 2011 The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares ...
Broihier, Heather T +3 more
core +2 more sources