Results 11 to 20 of about 12,444 (259)
Non-transport functions of motor proteins in corticogenesis [PDF]
Frontiers in Cell and Developmental BiologyCerebral cortex development is a tightly coordinated sequence of interconnected processes: proliferation of neural progenitors, neuronal migration, neurite differentiation, axonal pathfinding, and synaptogenesis.
Natalia Mitina +5 more
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Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins?
Frontiers in PhysiologyInitially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions.
Markus Horsthemke +3 more
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Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment [PDF]
Cell Communication and SignalingBackground Class I myosins are essential mediators of membrane–cytoskeleton interactions that support key cellular processes such as endocytosis, secretion, intracellular trafficking, and mitosis.
Girish Rajendraprasad +8 more
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Single-molecule fluorescence microscopy reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of live inner ear hair cells [PDF]
Nature CommunicationsStereocilia are F-actin-based cylindrical protrusions on the apical surface of inner ear hair cells that function as biological mechanosensors of sound and acceleration.
Takushi Miyoshi +9 more
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Direct Regulation of Striated Muscle Myosins by Nitric Oxide and Endogenous Nitrosothiols
PLoS ONE, 2010 BackgroundNitric oxide (NO) has long been recognized to affect muscle contraction, both through activation of guanylyl cyclase and through modification of cysteines in proteins to yield S-nitrosothiols. While NO affects the contractile apparatus directly,
Benjamin Gaston +2 more
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The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression [PDF]
The Journal of Clinical InvestigationLoss-of-function mutations in genome maintenance genes fuel tumorigenesis through increased genomic instability. A subset of these tumor suppressors are challenging to identify due to context dependency, including functional interactions with other genes
Jayashree Thatte +17 more
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Class I Myosins, molecular motors involved in cell migration and cancer
Cell Adhesion & Migration, 2022 Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins.
Juan D. Diaz-Valencia +4 more
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Functional Role of Class III Myosins in Hair Cells
Frontiers in Cell and Developmental Biology, 2021 Cytoskeletal motors produce force and motion using the energy from ATP hydrolysis and function in a variety of mechanical roles in cells including muscle contraction, cargo transport, and cell division.
Joseph A. Cirilo +2 more
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Biochemical Journal, 1935 Whereas most proteins so far studied show spreading at their isoelectric points or on strongly acid solutions (we have examined more or less thoroughly ovalbumin, zein, gliadin, insulin, pepsin, trypsin, ovoglobulin, ovomucoid, caseinogen, globin and haemoglobin) some proteins do not spread, when tested by our usual technique. Gelatin is a bad spreader
E, Gorter, H, Van Ormondt
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Proceedings of the National Academy of Sciences, 2006 Myosins are a diverse family of actin-based molecular motors that appeared early in eukaryotic evolution. Just how early, and how diverse, has begun to become clear from work that appears in this issue of PNAS (1) and recent work from Nature (2). For most of its existence, the term “myosin” applied only to the actin-activated ATPase that forms the ...
Holly V, Goodson, Scott C, Dawson
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