Results 41 to 50 of about 20,573 (287)
Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes
Brain SciencesThe blood–brain barrier (BBB) comprises distinct cell types, including endothelial cells, pericytes, and astrocytes, and is essential for central nervous system (CNS) homeostasis by selectively regulating molecular transport and maintaining integrity. In
Ana Filipa Sobral +4 more
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Myosin repertoire expansion coincides with eukaryotic diversification in the Mesoproterozoic era
BMC Evolutionary Biology, 2017 Background The last eukaryotic common ancestor already had an amazingly complex cell possessing genomic and cellular features such as spliceosomal introns, mitochondria, cilia-dependent motility, and a cytoskeleton together with several intracellular ...
Martin Kollmar, Stefanie Mühlhausen
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The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi [PDF]
, 2016 Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient
Fernandes, Chantal +2 more
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Arabidopsis myosin XI-K localizes to the motile endomembrane vesicles associated with F-actin
Frontiers in Plant Science, 2012 Plant myosins XI were implicated in cell growth, F-actin organization, and organelle transport, with myosin XI-K being a critical contributor to each of these processes.
Valera V. Peremyslov +3 more
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Mechanosensing in myosin filament solves a 60 years old conflict in skeletal muscle modeling between high power output and slow rise in tension [PDF]
, 2016 Almost 60 years ago Andrew Huxley with his seminal paper \cite{Huxley1957} laid the foundation of modern muscle modeling, linking chemical events to mechanical performance.
Marcucci, Lorenzo, Reggiani, Carlo
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Pathophysiology of human hearing loss associated with variants in myosins
Frontiers in PhysiologyDeleterious variants of more than one hundred genes are associated with hearing loss including MYO3A, MYO6, MYO7A and MYO15A and two conventional myosins MYH9 and MYH14. Variants of MYO7A also manifest as Usher syndrome associated with dysfunction of the
Takushi Miyoshi +4 more
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
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Bioinformatics and Biology Insights, 2012 Myosins are one of the largest protein superfamilies with 24 classes. They have conserved structural features and catalytic domains yet show huge variation at different domains resulting in a variety of functions.
Divya P. Syamaladevi +6 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Myosin VI regulates the spatial organisation of mammalian transcription initiation
Nature Communications, 2022 The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a ...
Yukti Hari-Gupta +15 more
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