Results 41 to 50 of about 8,367,716 (316)

From aggressive driving to molecular motor traffic [PDF]

, 2006
Motivated by recent experimental results for the step sizes of dynein motor proteins, we develope a cellular automata model for intra-cellular traffic of dynein motors incorporating special features of the hindrance-dependent step size of the individual ...
Chowdhury, Debashish, Kunwar, Ambarish, Schadschneider, Andreas   +2 more
core   +4 more sources

Motor Proteins: Myosin Mechanosensors [PDF]

Current Biology, 2008
Mechanosensation is emerging as a general principle of myosin motors. As demonstrated in a recent study, the single-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small force range.
Kee, Yee-Seir, Robinson, Douglas N.
openaire   +2 more sources

Motor-driven Dynamics of Cytoskeletal FIlaments in Motility Assays [PDF]

, 2011
We model analytically the dynamics of a cytoskeletal filament in a motility assay. The filament is described as rigid rod free to slide in two dimensions.
A. F. Huxley, J. Howard, Kristian Müller-Nedebock, M. Cristina Marchetti, N. Kikuchi, Shiladitya Banerjee   +5 more
core   +3 more sources

Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment

Frontiers in Cellular Neuroscience, 2017
The selective transport of different cargoes into axons and dendrites underlies the polarized organization of the neuron. Although it has become clear that the combined activity of different motors determines the destination and selectivity of transport,
Anne F. J. Janssen, Roderick P. Tas, Petra van Bergeijk, Rosalie Oost, Casper C. Hoogenraad, Lukas C. Kapitein   +5 more
doaj   +1 more source

Nonlinearity of mechanochemical motions in motor proteins. [PDF]

PLoS Computational Biology, 2010
The assumption of linear response of protein molecules to thermal noise or structural perturbations, such as ligand binding or detachment, is broadly used in the studies of protein dynamics.
Yuichi Togashi, Toshio Yanagida, Alexander S Mikhailov   +2 more
doaj   +1 more source

Dendritic trafficking faces physiologically critical speed-precision tradeoffs

eLife, 2016
Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model
Alex H Williams, Cian O'Donnell, Terrence J Sejnowski, Timothy O'Leary   +3 more
doaj   +1 more source

Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte

eLife, 2017
The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non ...
Ross Nieuwburg, Dmitry Nashchekin, Maximilian Jakobs, Andrew P Carter, Philipp Khuc Trong, Raymond E Goldstein, Daniel St Johnston   +6 more
doaj   +1 more source

Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. [PDF]

, 2020
In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation.
A Espana, A Espana, A Gow, A Harris, A Roy, A Wilzen, AE Talpalar, AF Ribeiro Jr., C Francius, C Landry, DC Lu, E Audouard, E Audouard, E Palmesino, F Clotman, F Clotman, FJ Stam, FP Lemaigre, HS Rhee, I Laudadio, J Cai, KU Kabayiza, L Landmesser, L Landmesser, M Sander, M Toch, M Zuchner, NR Lorente De, O Kjaerulff, P Jacquemin, P Jacquemin, P Whelan, S Velasco, TM Jessell, V Vanhorenbeeck, VJ Lannoy, W Wang   +36 more
core   +1 more source

The Emerging Role of Mechanics in Synapse Formation and Plasticity

Frontiers in Cellular Neuroscience, 2018
The regulation of synaptic strength forms the basis of learning and memory, and is a key factor in understanding neuropathological processes that lead to cognitive decline and dementia.
Devrim Kilinc
doaj   +1 more source

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

Nature Communications, 2021
Mitochondrial transport toward both the plus- and minus-ends of microtubules is mediated by motor proteins linked to mitochondria by TRAK adaptor proteins.
Adam R. Fenton, Thomas A. Jongens, Erika L. F. Holzbaur   +2 more
doaj   +1 more source