Results 41 to 50 of about 297,493 (288)

Plasma Neurofilament Heavy Chain Levels Correlate to Markers of Late Stage Disease Progression and Treatment Response in SOD1(G93A) Mice that Model ALS [PDF]

, 2012
Background: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterised by progressive degeneration of motor neurons leading to death, typically within 3–5 years of symptom onset. The diagnosis of ALS is largely reliant
Greensmith Linda, Dick, J., Lu, C.H., Malaspina, A., Kalmar, B., Greensmith, L., Dick, J, Petzold, A.F.S., Petzold, A, Linda Greensmith, Malaspina Andrea, Petzold Axel, Greensmith, L, Kalmar Bernadett, Kalmar, B, Dick James, Lu Ching-Hua, Lu, CH, Bernadett Kalmar, James Dick, Ching-Hua Lu, Lu, C-H, Andrea Malaspina, Malaspina, A, Axel Petzold   +24 more
core   +1 more source

The Emerging Role of Mechanics in Synapse Formation and Plasticity

Frontiers in Cellular Neuroscience, 2018
The regulation of synaptic strength forms the basis of learning and memory, and is a key factor in understanding neuropathological processes that lead to cognitive decline and dementia.
Devrim Kilinc
doaj   +1 more source

The motors of protein import into chloroplasts [PDF]

Plant Signaling & Behavior, 2011
Chloroplast function is largely dependent on its resident proteins, most of which are encoded by the nuclear genome and are synthesized in cytosol. Almost all of these are imported through the translocons located in the outer and inner chloroplast envelope membranes. The motor protein that provides the driving force for protein import has been proposed
Shi, Lan-Xin, Theg, Steven M
openaire   +4 more sources

Helical Twist and Rotational Forces in the Mitotic Spindle

Biomolecules, 2019
The mitotic spindle segregates chromosomes into two daughter cells during cell division. This process relies on the precise regulation of forces acting on chromosomes as the cell progresses through mitosis.
Iva M. Tolić, Maja Novak, Nenad Pavin
doaj   +1 more source

Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues

Cells, 2020
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the deposition of misfolded proteins in the motor cortex and motor neurons.
Natasha Vassileff, Laura J. Vella, Harinda Rajapaksha, Mitch Shambrook, Amirmohammad Nasiri Kenari, Catriona McLean, Andrew F. Hill, Lesley Cheng   +7 more
doaj   +1 more source

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

Nature Communications, 2021
Mitochondrial transport toward both the plus- and minus-ends of microtubules is mediated by motor proteins linked to mitochondria by TRAK adaptor proteins.
Adam R. Fenton, Thomas A. Jongens, Erika L. F. Holzbaur   +2 more
doaj   +1 more source

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs

, 2011
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
E. M. Makarov (7607225), Evgeny M. Makarov, Andrew Bottrill, O. V. Makarova (7607222), Makarov, EM, Bottrill, A, N. Owen (7618997), Owen, N, Olga V. Makarova, Makarova, OV, A. Bottrill (7622258), Nicholas Owen   +11 more
core   +1 more source

Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1

Frontiers in Molecular Biosciences
Cytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing crucial roles in intracellular organisation and cell division.
Amit Kumawat
doaj   +1 more source

Dynamics of molecular motors in reversible burnt-bridge models

Condensed Matter Physics, 2010
Dynamic properties of molecular motors whose motion is powered by interactions with specific lattice bonds are studied theoretically with the help of discrete-state stochastic "burnt-bridge" models.
M.N. Artyomov, A.Yu. Morozov, A.B. Kolomeisky   +2 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source