Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs [PDF]
, 2011 Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
E. M. Makarov (7607225) +11 more
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The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]
, 1992 We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Tsim, K. W. +13 more
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Motor Proteins and Spermatogenesis
, 2021 Unlike the intermediate filament- and septin-based cytoskeletons which are apolar structures, the microtubule (MT) and actin cytoskeletons are polarized structures in mammalian cells and tissues including the testis, most notable in Sertoli cells. In the
C. Yan Cheng +15 more
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Investigating how changes in the levels of kinesins impact neuronal health in Drosophila and human iPSC-derived neurons AD model [PDF]
Open BiologyAlzheimer’s disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. Understanding the molecular pathology of AD may help identify new ways to reduce neuronal damage.
Deepthy Francis +8 more
doaj +1 more source
The landscape of human mutually exclusive splicing
Molecular Systems Biology, 2017 Mutually exclusive splicing of exons is a mechanism of functional gene and protein diversification with pivotal roles in organismal development and diseases such as Timothy syndrome, cardiomyopathy and cancer in humans.
Klas Hatje +10 more
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A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity [PDF]
, 2010 Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L. +24 more
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Single molecule thermodynamics of ATP synthesis by F1-ATPase
New Journal of Physics, 2015 F _o F _1 -ATP synthase is a factory for synthesizing ATP in virtually all cells. Its core machinery is the subcomplex F _1 -motor (F _1 -ATPase) and performs the reversible mechanochemical coupling.
Shoichi Toyabe, Eiro Muneyuki
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Connecting two arrays: The emerging role of actin-microtubule cross-linking motor proteins
Frontiers in Plant Science, 2015 The cytoskeleton of plant cells, consisting of actin filaments (AFs) and microtubules (MTs), is a central structure for various intracellular processes, such as cell division, isotropic and polar growth, vesicle transport, cell shape and morphogenesis ...
René eSchneider, Staffan ePersson
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Cortical proteins may provide motor resilience in older adults
Scientific Reports, 2021 Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that ...
Aron S. Buchman +11 more
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Frontiers in Cellular Neuroscience, 2015 Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues
Orwa eAboud +5 more
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