Results 21 to 30 of about 297,493 (288)

Myosin repertoire expansion coincides with eukaryotic diversification in the Mesoproterozoic era

BMC Evolutionary Biology, 2017
Background The last eukaryotic common ancestor already had an amazingly complex cell possessing genomic and cellular features such as spliceosomal introns, mitochondria, cilia-dependent motility, and a cytoskeleton together with several intracellular ...
Martin Kollmar, Stefanie Mühlhausen
doaj   +1 more source

The role of motor proteins in endosomal sorting [PDF]

, 2011
Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Sylvie D Hunt, David J Stephens, Stephens, DJ   +3 more
core   +1 more source

Kinesin-14 : the roots of reversal [PDF]

, 2010
Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross, R. A., Cross Robert A, Robert A Cross   +2 more
core   +1 more source

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]

, 1992
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Tsim, K. W., McMahan, U. J., Escher, G., Gensch, Erin M., Tsim, Karl W.K., Escher, Gérard, Kroger, S., Kröger, Stephan, Horton, Sharon E., Ruegg, M. A., Tsim, Karl W. K., Horton, S. E., Gensch, E. M., Ruegg, Markus A.   +13 more
core   +1 more source

FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA [PDF]

, 2012
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder spinal muscular atrophy (SMA).
Das, Rita, Maniatis, Tom, Sharma, A, Yan, Biao, Tapia, JC, Gygi, Steve P., Monica A. Carrasco, Shneider, NA, Nishimura, AL, Chen, Shi, Yu, Yong, Sharma, Aarti, Yan, B, Gygi, SP, Christopher E. Shaw, Yamazaki, T, Steve P. Gygi, Siddharthan Chandran, Reed, Robin, Yu, Y, Aarti Sharma, Reed, R, Yong Yu, Rita Das, Das, R, Carrasco, Monica A., Zhai, Bo, Shneider, Neil A., Chen, S, Juan C. Tapia, Tapia, Juan C., Agnes Lumi Nishimura, Lalancette-Hebert, Melanie, Haertlein, TC, Tom Maniatis, Lalancette-Hebert, M, Biao Yan, Carrasco, MA, Neil A. Shneider, Yamazaki, Tomohiro, Nishimura, Agnes Lumi, Sullivan, G, Maniatis, T, Shaw, Christopher E., Shi Chen, Zhai, B, Melanie Lalancette-Hebert, Sullivan, Gareth, Tyler C. Haertlein, Shaw, CE, Chandran, S, Haertlein, Tyler C., Tomohiro Yamazaki, Gareth Sullivan, Robin Reed, Bo Zhai, Chandran, Siddharthan   +56 more
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The landscape of human mutually exclusive splicing

Molecular Systems Biology, 2017
Mutually exclusive splicing of exons is a mechanism of functional gene and protein diversification with pivotal roles in organismal development and diseases such as Timothy syndrome, cardiomyopathy and cancer in humans.
Klas Hatje, Raza‐Ur Rahman, Ramon O Vidal, Dominic Simm, Björn Hammesfahr, Vikas Bansal, Ashish Rajput, Michel Edwar Mickael, Ting Sun, Stefan Bonn, Martin Kollmar   +10 more
doaj   +1 more source

Connecting two arrays: The emerging role of actin-microtubule cross-linking motor proteins

Frontiers in Plant Science, 2015
The cytoskeleton of plant cells, consisting of actin filaments (AFs) and microtubules (MTs), is a central structure for various intracellular processes, such as cell division, isotropic and polar growth, vesicle transport, cell shape and morphogenesis ...
René eSchneider, Staffan ePersson
doaj   +1 more source

Single molecule thermodynamics of ATP synthesis by F1-ATPase

New Journal of Physics, 2015
F _o F _1 -ATP synthase is a factory for synthesizing ATP in virtually all cells. Its core machinery is the subcomplex F _1 -motor (F _1 -ATPase) and performs the reversible mechanochemical coupling.
Shoichi Toyabe, Eiro Muneyuki
doaj   +1 more source

Investigating how changes in the levels of kinesins impact neuronal health in Drosophila and human iPSC-derived neurons AD model [PDF]

Open Biology
Alzheimer’s disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. Understanding the molecular pathology of AD may help identify new ways to reduce neuronal damage.
Deepthy Francis, Francesco Paonessa, Victoria L. Hewitt, Maria Southall, Isabel Peset, Alexander J. Whitworth, Frederick J. Livesey, Caroline C. G. Fabre, Isabel M. Palacios   +8 more
doaj   +1 more source

Cortical proteins may provide motor resilience in older adults

Scientific Reports, 2021
Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that ...
Aron S. Buchman, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Shinya Tasaki, Chris Gaiteri, Robert S. Wilson, Francine Grodstein, Julie A. Schneider, Hans-Ulrich Klein, Philip L. De Jager, David A. Bennett   +11 more
doaj   +1 more source