Results 11 to 20 of about 2,946,409 (249)
Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development [PDF]
Frontiers in Cellular Neuroscience, 2016 Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller +12 more
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Motor proteins at the mitochondria-cytoskeleton interface. [PDF]
J Cell Sci, 2021 Mitochondria are multifunctional organelles that not only produce energy for the cell, but are also important for cell signalling, apoptosis and many biosynthetic pathways.
Kruppa AJ, Buss F.
europepmc +3 more sources
Structural Studies on Bacteriophage Portal Proteins [PDF]
, 2013 In tailed bacteriophages and evolutionarily related herpes viruses, the portal protein is a central component of the DNA packaging molecular motor, which translocates viral genomic DNA into a preformed procapsid.
Luan, Weisha
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Micron-scale geometrical features of microtubules as regulators of microtubule organization
eLife, 2021 The organization of micron-sized, multi-microtubule arrays from individual microtubules is essential for diverse cellular functions. The microtubule polymer is largely viewed as a passive building block during the organization process.
Nandini Mani +2 more
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Frontiers in Cell and Developmental Biology, 2022 Tunnelling nanotubes (TNTs) are membranous connections that represent a unique type of intercellular communication in different cell types. They are associated with cell physiology and cancer pathology.
Nataša Resnik +7 more
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Molecular switch-like regulation in motor proteins. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2018 Motor proteins are powered by nucleotide hydrolysis and exert mechanical work to carry out many fundamental biological tasks. To ensure their correct and efficient performance, the motors' activities are allosterically regulated by additional factors ...
Tafoya S, Bustamante C.
europepmc +2 more sources
Mechanisms of Regulation in Intraflagellar Transport
Cells, 2022 Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia act as antennae to sense a cell’s environment and are involved in a wide range of signaling pathways essential for development. Motile cilia drive cell locomotion
Wouter Mul +2 more
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Myosin repertoire expansion coincides with eukaryotic diversification in the Mesoproterozoic era
BMC Evolutionary Biology, 2017 Background The last eukaryotic common ancestor already had an amazingly complex cell possessing genomic and cellular features such as spliceosomal introns, mitochondria, cilia-dependent motility, and a cytoskeleton together with several intracellular ...
Martin Kollmar, Stefanie Mühlhausen
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The role of motor proteins in endosomal sorting [PDF]
, 2011 Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie +3 more
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Kinesin-14 : the roots of reversal [PDF]
, 2010 Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross, R. A. +2 more
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