Results 31 to 40 of about 2,946,409 (249)

Symmetry Breaking and Emergence of Directional Flows in Minimal Actomyosin Cortices

Cells, 2020
Cortical actomyosin flows, among other mechanisms, scale up spontaneous symmetry breaking and thus play pivotal roles in cell differentiation, division, and motility.
Sven K. Vogel, Christian Wölfer, Diego A. Ramirez-Diaz, Robert J. Flassig, Kai Sundmacher, Petra Schwille   +5 more
doaj   +1 more source

Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment

Frontiers in Cellular Neuroscience, 2017
The selective transport of different cargoes into axons and dendrites underlies the polarized organization of the neuron. Although it has become clear that the combined activity of different motors determines the destination and selectivity of transport,
Anne F. J. Janssen, Roderick P. Tas, Petra van Bergeijk, Rosalie Oost, Casper C. Hoogenraad, Lukas C. Kapitein   +5 more
doaj   +1 more source

Nonlinearity of mechanochemical motions in motor proteins. [PDF]

PLoS Computational Biology, 2010
The assumption of linear response of protein molecules to thermal noise or structural perturbations, such as ligand binding or detachment, is broadly used in the studies of protein dynamics.
Yuichi Togashi, Toshio Yanagida, Alexander S Mikhailov   +2 more
doaj   +1 more source

Dendritic trafficking faces physiologically critical speed-precision tradeoffs

eLife, 2016
Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model
Alex H Williams, Cian O'Donnell, Terrence J Sejnowski, Timothy O'Leary   +3 more
doaj   +1 more source

Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte

eLife, 2017
The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non ...
Ross Nieuwburg, Dmitry Nashchekin, Maximilian Jakobs, Andrew P Carter, Philipp Khuc Trong, Raymond E Goldstein, Daniel St Johnston   +6 more
doaj   +1 more source

The Emerging Role of Mechanics in Synapse Formation and Plasticity

Frontiers in Cellular Neuroscience, 2018
The regulation of synaptic strength forms the basis of learning and memory, and is a key factor in understanding neuropathological processes that lead to cognitive decline and dementia.
Devrim Kilinc
doaj   +1 more source

Helical Twist and Rotational Forces in the Mitotic Spindle

Biomolecules, 2019
The mitotic spindle segregates chromosomes into two daughter cells during cell division. This process relies on the precise regulation of forces acting on chromosomes as the cell progresses through mitosis.
Iva M. Tolić, Maja Novak, Nenad Pavin
doaj   +1 more source

Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues

Cells, 2020
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the deposition of misfolded proteins in the motor cortex and motor neurons.
Natasha Vassileff, Laura J. Vella, Harinda Rajapaksha, Mitch Shambrook, Amirmohammad Nasiri Kenari, Catriona McLean, Andrew F. Hill, Lesley Cheng   +7 more
doaj   +1 more source

Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1

Frontiers in Molecular Biosciences
Cytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing crucial roles in intracellular organisation and cell division.
Amit Kumawat
doaj   +1 more source

Dynamics of molecular motors in reversible burnt-bridge models

Condensed Matter Physics, 2010
Dynamic properties of molecular motors whose motion is powered by interactions with specific lattice bonds are studied theoretically with the help of discrete-state stochastic "burnt-bridge" models.
M.N. Artyomov, A.Yu. Morozov, A.B. Kolomeisky   +2 more
doaj   +1 more source