Results 31 to 40 of about 297,493 (288)
Frontiers in Cellular Neuroscience, 2015 Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues
Orwa eAboud +5 more
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Symmetry Breaking and Emergence of Directional Flows in Minimal Actomyosin Cortices
Cells, 2020 Cortical actomyosin flows, among other mechanisms, scale up spontaneous symmetry breaking and thus play pivotal roles in cell differentiation, division, and motility.
Sven K. Vogel +5 more
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Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]
, 2014 Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S +13 more
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Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]
, 1999 Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Woehlke, G. +5 more
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Motor Proteins: Myosin Mechanosensors [PDF]
Current Biology, 2008 Mechanosensation is emerging as a general principle of myosin motors. As demonstrated in a recent study, the single-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small force range.
Kee, Yee-Seir, Robinson, Douglas N.
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Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment
Frontiers in Cellular Neuroscience, 2017 The selective transport of different cargoes into axons and dendrites underlies the polarized organization of the neuron. Although it has become clear that the combined activity of different motors determines the destination and selectivity of transport,
Anne F. J. Janssen +5 more
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Nonlinearity of mechanochemical motions in motor proteins. [PDF]
PLoS Computational Biology, 2010 The assumption of linear response of protein molecules to thermal noise or structural perturbations, such as ligand binding or detachment, is broadly used in the studies of protein dynamics.
Yuichi Togashi +2 more
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Structures of kinesin motor proteins [PDF]
Cell Motility, 2009 AbstractAlmost 25 years of kinesin research have led to the accumulation of a large body of knowledge about this widespread superfamily of motor and nonmotor proteins present in all eukaryotic cells. This review covers developments in kinesin research with an emphasis on structural aspects obtained by X‐ray crystallography and cryoelectron microscopy 3‐
Marx, A., Hoenger, A., Mandelkow, E.
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Dendritic trafficking faces physiologically critical speed-precision tradeoffs
eLife, 2016 Nervous system function requires intracellular transport of channels, receptors, mRNAs, and other cargo throughout complex neuronal morphologies. Local signals such as synaptic input can regulate cargo trafficking, motivating the leading conceptual model
Alex H Williams +3 more
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eLife, 2017 The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non ...
Ross Nieuwburg +6 more
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