Results 51 to 60 of about 8,367,716 (316)

Motor proteins traffic regulation by supply-demand balance of resources

, 2014
In cells and in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow ...
Ciandrini, Luca, Dauloudet, O., Neri, I., Parmeggiani, A., Walter, Jean-Charles   +4 more
core   +3 more sources

Length control of microtubules by depolymerizing motor proteins [PDF]

, 2008
In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the ...
B. S. Govindan, D. Chowdhury, Hunter A. W., M. Gopalakrishnan   +3 more
core   +2 more sources

Helical Twist and Rotational Forces in the Mitotic Spindle

Biomolecules, 2019
The mitotic spindle segregates chromosomes into two daughter cells during cell division. This process relies on the precise regulation of forces acting on chromosomes as the cell progresses through mitosis.
Iva M. Tolić, Maja Novak, Nenad Pavin
doaj   +1 more source

Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues

Cells, 2020
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the deposition of misfolded proteins in the motor cortex and motor neurons.
Natasha Vassileff, Laura J. Vella, Harinda Rajapaksha, Mitch Shambrook, Amirmohammad Nasiri Kenari, Catriona McLean, Andrew F. Hill, Lesley Cheng   +7 more
doaj   +1 more source

Step size of the rotary proton motor in single FoF1-ATP synthase from a thermoalkaliphilic bacterium by DCO-ALEX FRET

, 2012
Thermophilic enzymes can operate at higher temperatures but show reduced activities at room temperature. They are in general more stable during preparation and, accordingly, are considered to be more rigid in structure.
Boersch, Michael, Cook, Gregory M., Ernst, Stefan, Hammann, Eva, Keis, Stefanie, Matthies, Doreen, Meier, Thomas, Zappe, Andrea   +7 more
core   +1 more source

Nematic and Polar order in Active Filament Solutions

, 2005
Using a microscopic model of interacting polar biofilaments and motor proteins, we characterize the phase diagram of both homogeneous and inhomogeneous states in terms of experimental parameters.
A. Ahmadi, B. Alberts, D. Humphrey, J. Howard, K. Takiguchi, M. C. Marchetti, T. B. Liverpool   +6 more
core   +1 more source

Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]

, 1991
The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K, Malik, F, Ohashi, S, Okuno, M, Shimizu, T, Toyoshima, YY, Vale, RD   +6 more
core   +2 more sources

Dynamics of molecular motors in reversible burnt-bridge models

Condensed Matter Physics, 2010
Dynamic properties of molecular motors whose motion is powered by interactions with specific lattice bonds are studied theoretically with the help of discrete-state stochastic "burnt-bridge" models.
M.N. Artyomov, A.Yu. Morozov, A.B. Kolomeisky   +2 more
doaj   +1 more source

Bidirectional motion of filaments: Role of motor proteins and passive cross linkers [PDF]

, 2017
In eukaryotic cells, motor proteins (MP) bind to cytoskeletal filaments and move along them in a directed manner generating active stresses. During cell division a spindle structure of overlapping antiparallel microtubules (MT) form whose stability and ...
Chaudhuri, Debasish, Ghosh, Subhadip, Muhuri, Sudipto, Pagonabarraga, Ignacio, Pradeep, V N S   +4 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source