Results 11 to 20 of about 9,409 (173)
Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility. [PDF]
PLoS ONE, 2017 Dynactin is a dynein-regulating protein that increases the processivity of dynein movement on microtubules. Recent studies have shown that a tripartite complex of dynein-dynactin-Bicaudal D2 is essential for highly processive movement.
Takuya Kobayashi +3 more
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Human dynein–dynactin is a fast processive motor in living cells [PDF]
eLifeMinus-end directed transport along microtubules in eukaryotes is primarily mediated by cytoplasmic dynein and its cofactor dynactin. Significant advances have been made in recent years characterizing human dynein–dynactin structure and function using in ...
Vikash Verma +2 more
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Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. [PDF]
PLoS ONE, 2013 Cytoplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling and cell division. The principal subunits that mediate this interaction are the dynein intermediate chain (IC) and the dynactin p150(Glued); however ...
Amanda E Siglin +8 more
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Brazilian Journal of Medical and Biological ResearchAxons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of Parkinson's disease (PD), with axonal degeneration preceding the loss of cell bodies.
Yongmei Wu +14 more
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Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam. [PDF]
PLoS ONE, 2008 BACKGROUND:Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained.
Jacob Shun-Jen Yang +2 more
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Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1 [PDF]
Frontiers in Molecular BiosciencesCytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing crucial roles in intracellular organisation and cell division.
Amit Kumawat
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NuMA and Ninein: Dynein Cargo-Adaptors Without a Classical Cargo [PDF]
CellsDynein is a minus-end-directed microtubule motor that transports a variety of cargoes. Cargo specificity is mediated by a class of adaptor proteins that bind to the interface between dynein and dynactin, along the length of the Arp1 filament of dynactin,
Keying Guo, Andreas Merdes
doaj +2 more sources
Nature Communications, 2018 A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes.
In-Gyun Lee +5 more
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Synthetic cargo adaptors reveal molecular features that enhance dynein activation [PDF]
Nature CommunicationsCytoplasmic dynein-1 (dynein) facilitates the microtubule-based retrograde trafficking of all cellular cargo. To become active, dynein binds dynactin and one of many cargo-specific adaptors forming the dynein-dynactin-adaptor transport complex.
Aravintha Siva +10 more
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Perry Disease: Concept of a New Disease and Clinical Diagnostic Criteria [PDF]
Journal of Movement Disorders, 2021 Perry disease is a hereditary neurodegenerative disease with autosomal dominant inheritance. It is characterized by parkinsonism, psychiatric symptoms, unexpected weight loss, central hypoventilation, and transactive-response DNA-binding protein of 43kD (
Yoshio Tsuboi +2 more
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