Results 11 to 20 of about 7,885 (177)
The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity. [PDF]
J NeurochemTo survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Turner ED, Twelvetrees AE.
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Characterization of the Dynein-Dynactin Interaction [PDF]
, 2022 In eukaryotic cells many biological processes like cell division, the distribution of vesicles and organelles require the dynamic rearrangement of molecules and cellular components. These rearrangements are controlled by three superfamilies of motor proteins, which move along the cytoskeletal tracks.
Findeisen, Peggy +4 more
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Activation and regulation of the dynein-dynactin-NuMA complex. [PDF]
Nat Chem BiolAbstract During cell division, NuMA orchestrates the focusing of microtubule minus-ends in spindle poles and cortical force generation on astral microtubules by interacting with dynein motors, microtubules, and other cellular factors. Here, we used in vitro reconstitution, cryo-electron microscopy, and live cell imaging to understand ...
Aslan M +10 more
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Dynactin Is Necessary for Synapse Stabilization [PDF]
Neuron, 2002 We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex.
Eaton, Benjamin A +2 more
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Microtubule Motors: Doin’ It without Dynactin [PDF]
Current Biology, 2013 The minus-end directed microtubule motor protein cytoplasmic dynein contributes to many aspects of cell division and it is generally believed that these mitotic functions require the dynein activator and processivity factor, dynactin. New research now shows that dynein accomplishes many of its mitotic functions without dynactin.
Wadsworth, Patricia, Lee, Wei-Lih
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eLife, 2021 In eukaryotic cells, intracellular components are organized by the microtubule motors cytoplasmic dynein-1 (dynein) and kinesins, which are linked to cargos via adaptor proteins.
Jenna R Christensen +6 more
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Dynactin is required for bidirectional organelle transport [PDF]
The Journal of Cell Biology, 2003 Kinesin II is a heterotrimeric plus end–directed microtubule motor responsible for the anterograde movement of organelles in various cell types. Despite substantial literature concerning the types of organelles that kinesin II transports, the question of how this motor associates with cargo organelles remains unanswered.
Deacon, Sean W. +6 more
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Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein
BMC Evolutionary Biology, 2012 Background Dynactin is a large multisubunit protein complex that enhances the processivity of cytoplasmic dynein and acts as an adapter between dynein and the cargo.
Hammesfahr Björn, Kollmar Martin
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Interaction of tau protein with the dynactin complex [PDF]
The EMBO Journal, 2007 Tau is an axonal microtubule-associated protein involved in microtubule assembly and stabilization. Mutations in Tau cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and tau aggregates are present in Alzheimer's disease and other tauopathies.
Enrico, Magnani +8 more
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Mechanism of Dynamitin-mediated Disruption of Dynactin [PDF]
Journal of Biological Chemistry, 2007 Dynamitin is a commonly used inhibitor of cytoplasmic dynein-based motility in living cells. Dynamitin does not inhibit dynein directly but instead acts by causing disassembly of dynactin, a multiprotein complex required for dynein-based movement. In dynactin, dynamitin is closely associated with the subunits p150(Glued) and p24, which together form ...
Karin A, Melkonian +4 more
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