Results 41 to 50 of about 8,973 (210)

New insights into the mechanism of dynein motor regulation by lissencephaly-1

eLife, 2020
Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
Steven M Markus, Matthew G Marzo, Richard J McKenney   +2 more
doaj   +1 more source

Mutant dynactin in motor neuron disease [PDF]

Nature Genetics, 2003
Impaired axonal transport in motor neurons has been proposed as a mechanism for neuronal degeneration in motor neuron disease. Here we show linkage of a lower motor neuron disease to a region of 4 Mb at chromosome 2p13. Mutation analysis of a gene in this interval that encodes the largest subunit of the axonal transport protein dynactin showed a single
Imke, Puls, Catherine, Jonnakuty, Bernadette H, LaMonte, Erika L F, Holzbaur, Mariko, Tokito, Eric, Mann, Mary Kay, Floeter, Kimberly, Bidus, Dennis, Drayna, Shin J, Oh, Robert H, Brown, Christy L, Ludlow, Kenneth H, Fischbeck   +12 more
openaire   +2 more sources

Characterization of the p22 Subunit of Dynactin Reveals the Localization of Cytoplasmic Dynein and Dynactin to the Midbody of Dividing Cells [PDF]

The Journal of Cell Biology, 1998
Dynactin, a multisubunit complex that binds to the microtubule motor cytoplasmic dynein, may provide a link between dynein and its cargo. Many subunits of dynactin have been characterized, elucidating the multifunctional nature of this complex. Using a dynein affinity column, p22, the smallest dynactin subunit, was isolated and microsequenced.
S, Karki, B, LaMonte, E L, Holzbaur
openaire   +2 more sources

ZW10 Helps Recruit Dynactin and Dynein to the Kinetochore [PDF]

The Journal of Cell Biology, 1998
Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores. Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar ...
Starr, Daniel A, Williams, Byron C, Hays, Thomas S, Goldberg, Michael L   +3 more
openaire   +4 more sources

Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]

, 2012
The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
core   +1 more source

Lis1 activates dynein motility by modulating its pairing with dynactin [PDF]

, 2020
Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an inhibitor or an activator of mammalian dynein motility.
Sara Volz, Yildiz, Ahmet, Kusakci, Emre, Mohamed M. Elshenawy, Janina Baumbach, Ahmet Yildiz, Elshenawy, Mohamed M, Volz, Sara, Simon L. Bullock, Bullock, Simon L, Baumbach, Janina, Emre Kusakci   +11 more
core   +1 more source

Dynein and dynactin schematic.

, 2013
A. Dynein and dynactin macromolecular complex organization. Both complexes are drawn approximately to scale from EM reconstruction images. B. Schematic of domain structure and binding sites of both the dynein intermediate chain isoform 2C and dynactin ...
Shangjin Sun (399678), Tatyana Polenova (226142), Sarah Tan (399680), John A. Cooper (170679), Martin Poenie (399681), James D. Lear (399682), Amanda E. Siglin (399677), John C. Williams (262561), Jeffrey K. Moore (399679)   +8 more
core   +1 more source

Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic. [PDF]

, 2008
Alpha-epithelial catenin (E-catenin) is an important cell-cell adhesion protein. In this study, we show that alpha-E-catenin also regulates intracellular traffic by binding to the dynactin complex component dynamitin.
Valeri Vasioukhin, Wen-Hui Lien, Lien, Wen-Hui, Vladimir I. Gelfand, Gelfand, Vladimir I, Vasioukhin, Valeri   +5 more
core   +1 more source

Analysis of the Dynein-Dynactin Interaction In Vitro and In Vivo [PDF]

Molecular Biology of the Cell, 2003
Cytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context.
Stephen J, King, Christa L, Brown, Kerstin C, Maier, Nicholas J, Quintyne, Trina A, Schroer   +4 more
openaire   +2 more sources

Kazrin is an endosomal adaptor for dynein/dynactin [PDF]

, 2021
Abstract Kazrin is a protein widely expressed in vertebrates whose depletion causes a myriad of developmental defects, in part derived from altered cell adhesion, impaired cell migration and failure to undergo Epidermal to Mesenchymal Transition (EMT).
Ines Hernandez-Perez, Adrian Baumann, Javier Rubio, Henrique Girao, Elena Rebollo, Anna M. Aragay, Maria Isabel Geli   +6 more
openaire   +1 more source