Results 61 to 70 of about 8,973 (210)

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin

Nature Communications, 2022
Organellar transport is carefully regulated, and endolysosome localized ARL8 is important for kinesin recruitment and anterograde movement. Here, the authors show that RUFY3 and RUFY4 promote retrograde transport of endolysosomes by mediating interaction
Tal Keren-Kaplan, Amra Sarić, Saikat Ghosh, Chad D. Williamson, Rui Jia, Yan Li, Juan S. Bonifacino   +6 more
doaj   +1 more source

Bicd2, Dynactin, And Lis1 Cooperate In Regulating Dynein Recruitment To Cellular Structures [PDF]

, 2012
Cytoplasmic dynein is the major microtubule minus-end-directed cellular motor. Most dynein activities require dynactin, but the mechanisms regulating cargo-dependent dynein-dynactin interaction are poorly understood.
Razafsky, David S., Grigoriev, Ilya, Serra-Marques, Andrea, Splinter, Daniël, Schlager, Max A.   +4 more
core   +2 more sources

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors

Frontiers in Immunology, 2018
The different cytoskeleton systems and their connecting molecular motors move vesicles and intracellular organelles to shape cells. Polarized cells with specialized functions display an exquisite spatio-temporal regulation of both cytoskeletal and ...
Noa Beatriz Martín-Cófreces, Noa Beatriz Martín-Cófreces, Francisco Sánchez-Madrid, Francisco Sánchez-Madrid   +3 more
doaj   +1 more source

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport

Nature Communications, 2023
The mechanisms of microtubule-based mitochondrial transport remain poorly understood. Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to ...
John T. Canty, Andrew Hensley, Merve Aslan, Amanda Jack, Ahmet Yildiz   +4 more
doaj   +1 more source

Proposed mechanism of dynein-dynactin binding.

, 2013
Based on the refinement of the dynein-dynactin interaction and the physical characterization of the individual fragments, we propose that the N-terminus of the dynein IC is disordered in the in the absence of dynactin.
Shangjin Sun (399678), Tatyana Polenova (226142), Sarah Tan (399680), John A. Cooper (170679), Martin Poenie (399681), James D. Lear (399682), Amanda E. Siglin (399677), John C. Williams (262561), Jeffrey K. Moore (399679)   +8 more
core   +1 more source

Novel Postzygotic Variants Associated With Hypomelanosis of Ito Expand the ACTB‐Related Neurocutaneous Disease Spectrum

Clinical Genetics, EarlyView.
We describe a previously unreported phenotype related to postzygotic ACTB variants with hypomelanosis of Ito, characterized by hypopigmentation associated or not with neurodevelopmental features, distinct from Becker presentations, bridging constitutional neurodevelopmental and somatic cutaneous phenotypes.
Estella Castillon, Paul Rollier, Didier Bessis, Laurent Pasquier, Caroline Racine, Alexis Praga, Pierre Vabres, Bertille Bonniaud, Paul Kuentz, Laurence Faivre   +9 more
wiley   +1 more source

The Dynactin Complex Enhances the Speed of Microtubule-Dependent Motions of Adenovirus Both Towards and Away from the Nucleus

Viruses, 2011
Unlike transport vesicles or organelles, human adenovirus (HAdV) directly binds to the microtubule minus end-directed motor dynein for transport to the nucleus. The dynein cofactor dynactin enhances nuclear transport of HAdV and boosts infection.
Martin F. Engelke, Christoph J. Burckhardt, Urs F. Greber, Matthias K. Morf   +3 more
doaj   +1 more source

βIII Spectrin Binds to the Arp1 Subunit of Dynactin [PDF]

Journal of Biological Chemistry, 2001
Cytoplasmic dynein is an intracellular motor responsible for endoplasmic reticulum-to-Golgi vesicle trafficking and retrograde axonal transport. The accessory protein dynactin has been proposed to mediate the association of dynein with vesicular cargo.
E A, Holleran, L A, Ligon, M, Tokito, M C, Stankewich, J S, Morrow, E L, Holzbaur   +5 more
openaire   +2 more sources