Results 71 to 80 of about 14,978 (204)
Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. [PDF]
PLoS Biology, 2013 Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease.
Jacob E Lazarus +3 more
doaj +1 more source
Regulation of polarised growth in fungi [PDF]
, 2008 Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo +112 more
core +1 more source
Trina Schroer: What’s cooking on dynactin [PDF]
Journal of Cell Biology, 2013 Schroer studies the composition and activity of dynactin.
openaire +1 more source
Dynactin 3D Structure: Implications for Assembly and Dynein Binding [PDF]
Journal of Molecular Biology, 2014 The multisubunit protein complex, dynactin, is an essential component of the cytoplasmic dynein motor. High-resolution structural work on dynactin and the dynein/dynactin supercomplex has been limited to small subunits and recombinant fragments that do not report fully on either ≈1MDa assembly.
Hiroshi, Imai +3 more
openaire +2 more sources
The human cytoplasmic dynein interactome reveals novel activators of motility
eLife, 2017 In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine +8 more
doaj +1 more source
PAR-dependent and geometry-dependent mechanisms of spindle positioning. [PDF]
, 2003 During intrinsically asymmetric division, the spindle is oriented onto a polarized axis specified by a group of conserved PAR proteins. Extrinsic geometric asymmetry generated by cell shape also affects spindle orientation in some systems, but how ...
Hayashi, Adam +3 more
core
Lis1 is an initiation factor for dynein-driven organelle transport [PDF]
, 2012 The molecular motor cytoplasmic dynein is responsible for most minus-end–directed, microtubule-based transport in eukaryotic cells. It is especially important in neurons, where defects in microtubule-based motility have been linked to neurological ...
Egan, Martin +2 more
core +1 more source
Dynactin drives dynein without microtubule binding [PDF]
The Journal of Cell Biology, 2007 Dynactin might bind to and organize microtubules. But it doesn't need to bind microtubules to jump-start dynein motoring, Kim et al. report on page 641. Figure 1 Organelle cargo distribution is similar in wild-type cells (left) and cells expressing nonmicrotubule-binding dynactin (right), indicating that transport remains intact ...
openaire +1 more source
Frontiers in Cell and Developmental Biology, 2016 Unexpectedly, members of the Rab VI subfamily exhibit considerable variation in their effects on Golgi organization and trafficking. By fluorescence microscopy, neither depletion nor overexpression of the GDP-locked form of Rab6a/a’, the first trans ...
Shijie eLiu +4 more
doaj +1 more source
Diet and cell size both affect queen-worker differentiation through DNA methylation in honey bees (Apis mellifera, Apidae). [PDF]
PLoS ONE, 2011 Young larvae of the honey bee (Apis mellifera) are totipotent; they can become either queens (reproductives) or workers (largely sterile helpers). DNA methylation has been shown to play an important role in this differentiation. In this study, we examine
Yuan Yuan Shi +5 more
doaj +1 more source