Results 71 to 80 of about 9,409 (173)

Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. [PDF]

PLoS Biology, 2013
Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease.
Jacob E Lazarus, Armen J Moughamian, Mariko K Tokito, Erika L F Holzbaur   +3 more
doaj   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1218-1229, September 2026.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

The p25 subunit of the dynactin complex is required for dynein-early endosome interaction [PDF]

, 2011
11 páginas, 5 figuras, 1 tabla -- PAGS nros. 1245-1255Cytoplasmic dynein transports various cellular cargoes including early endosomes, but how dynein is linked to early endosomes is unclear.
Abenza, Juan F., Jun Zhang, Miguel A. Peñalva, Yao, Xuanli, Juan F. Abenza, Xin Xiang, Xuanli Yao, Peñalva, Miguel Ángel, Fischer, Lauren, Lauren Fischer, Zhang, Jun, Xiang, Xin   +11 more
core   +1 more source

The human cytoplasmic dynein interactome reveals novel activators of motility

eLife, 2017
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson   +8 more
doaj   +1 more source

Novel Postzygotic Variants Associated With Hypomelanosis of Ito Expand the ACTB‐Related Neurocutaneous Disease Spectrum

Clinical Genetics, Volume 110, Issue 3, Page 369-373, September 2026.
We describe a previously unreported phenotype related to postzygotic ACTB variants with hypomelanosis of Ito, characterized by hypopigmentation associated or not with neurodevelopmental features, distinct from Becker presentations, bridging constitutional neurodevelopmental and somatic cutaneous phenotypes.
Estella Castillon, Paul Rollier, Didier Bessis, Laurent Pasquier, Caroline Racine, Alexis Praga, Pierre Vabres, Bertille Bonniaud, Paul Kuentz, Laurence Faivre   +9 more
wiley   +1 more source

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3 [PDF]

, 2016
Metazoan cytoplasmic dynein moves processively along microtubules with the aid of dynactin and an adaptor protein that joins dynein and dynactin into a stable ternary complex.
Courtney M. Schroeder, Ronald D. Vale, Vale, Ronald D, Schroeder, Courtney M   +3 more
core   +1 more source

Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte

eLife, 2017
The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non ...
Ross Nieuwburg, Dmitry Nashchekin, Maximilian Jakobs, Andrew P Carter, Philipp Khuc Trong, Raymond E Goldstein, Daniel St Johnston   +6 more
doaj   +1 more source

tArp Is an Actin‐Related Protein Required for Ciliary Function That Is Conserved in Ciliates and Related Eukaryotic Groups

Journal of Eukaryotic Microbiology, Volume 73, Issue 5, September/October 2026.
ABSTRACT Cells exhibit a wide range of behaviors due to their diverse molecular systems, which have been established through the molecular evolution of individual species. Protein families generated through gene duplications may be involved in this process. The actin cytoskeleton is no exception.
Miku Kagawa, Minori Hagita, Takuro Nakayama, Kogiku Shiba, Takako Kato‐Minoura, Shinya Matsuda, Kazuo Inaba, Yuji Inagaki, Kentaro Nakano   +8 more
wiley   +1 more source

Dynein and dynactin schematic.

, 2013
A. Dynein and dynactin macromolecular complex organization. Both complexes are drawn approximately to scale from EM reconstruction images. B. Schematic of domain structure and binding sites of both the dynein intermediate chain isoform 2C and dynactin ...
Shangjin Sun (399678), Tatyana Polenova (226142), Sarah Tan (399680), John A. Cooper (170679), Martin Poenie (399681), James D. Lear (399682), Amanda E. Siglin (399677), John C. Williams (262561), Jeffrey K. Moore (399679)   +8 more
core   +1 more source

SORL1 variant links endosomal amyloid precursor protein mis‐sorting to axonal transport defects and neuronal dysfunction

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION SORL1 encodes the sorting receptor SORLA, a major genetic contributor to Alzheimer's disease (AD). Although SORL1 loss disrupts endosomal trafficking and promotes amyloidogenic amyloid precursor protein (APP) processing, the functional consequences of specific missense variants in human neurons remain unclear.
Miriam Lep, Klara Plesingrova, Jiri Sedmik, Sona Cesnarikova, Monica Feole, Ondrej Bernatik, Victorio Martin Pozo Devoto, Hana Hribkova, Katerina Amruz Cerna, Petr Fojtik, Nadezda Vaskovicova, Simona Bartova, Veronika Pospisilova, Tereza Vanova, Olav Michael Andersen, Dasa Bohaciakova, Jan Raska   +16 more
wiley   +1 more source