Results 71 to 80 of about 8,973 (210)
RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B
The FEBS Journal, EarlyView.The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal +4 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2015 Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues
Orwa eAboud +5 more
doaj +1 more source
Cryo-EM shows how dynactin recruits two dyneins for faster movement
, 2017 Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein/dynactin to distinct cargos.
Mohamed M. Elshenawy +6 more
core +1 more source
Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi +12 more
wiley +1 more source
The human cytoplasmic dynein interactome reveals novel activators of motility
eLife, 2017 In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine +8 more
doaj +1 more source
eLife, 2017 The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non ...
Ross Nieuwburg +6 more
doaj +1 more source
Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. [PDF]
PLoS Biology, 2013 Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease.
Jacob E Lazarus +3 more
doaj +1 more source
Dynactin polices two-way organelle traffic [PDF]
The Journal of Cell Biology, 2003 How is the bidirectional motion of organelles controlled? In this issue, Deacon et al. (2003) reveal the unexpected finding that dynactin (previously known to control dynein-based motility) binds to kinesin II and regulates anterograde movement of Xenopus melanosomes.
openaire +2 more sources
Structural organization of the dynein–dynactin complex bound to microtubules [PDF]
Nature Structural & Molecular Biology, 2015 Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex.
Chowdhury, Saikat +3 more
openaire +2 more sources
Molecular Ecology, Volume 35, Issue 9, May 2026.ABSTRACT Urbanisation is a pervasive form of anthropogenic environmental change and a driver of contemporary evolution. Yet, it remains unclear how demographic processes and environmentally associated genomic variation shape genomic patterns in cities and whether these responses depend on species‐specific ecological traits.
Lucie M. Baltz +4 more
wiley +1 more source