Results 71 to 80 of about 7,885 (177)
Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi +12 more
wiley +1 more source
Dysfunction of dynactin 1 in motor neuron degeneration
Rinsho Shinkeigaku, 2013 Dynactin 1 is an axon motor protein regulating retrograde transport of various proteins and vesicles including autophagosome. We previously demonstrated that the expression levels of dynacin 1 are markedly reduced in spinal motor neurons of sporadic ALS patients.
Katsuno, Masahisa +3 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2016 Unexpectedly, members of the Rab VI subfamily exhibit considerable variation in their effects on Golgi organization and trafficking. By fluorescence microscopy, neither depletion nor overexpression of the GDP-locked form of Rab6a/a’, the first trans ...
Shijie eLiu +4 more
doaj +1 more source
Diet and cell size both affect queen-worker differentiation through DNA methylation in honey bees (Apis mellifera, Apidae). [PDF]
PLoS ONE, 2011 Young larvae of the honey bee (Apis mellifera) are totipotent; they can become either queens (reproductives) or workers (largely sterile helpers). DNA methylation has been shown to play an important role in this differentiation. In this study, we examine
Yuan Yuan Shi +5 more
doaj +1 more source
Molecular Ecology, Volume 35, Issue 9, May 2026.ABSTRACT Urbanisation is a pervasive form of anthropogenic environmental change and a driver of contemporary evolution. Yet, it remains unclear how demographic processes and environmentally associated genomic variation shape genomic patterns in cities and whether these responses depend on species‐specific ecological traits.
Lucie M. Baltz +4 more
wiley +1 more source
eLife, 2016 Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
Lindsey Seldin +2 more
doaj +1 more source
BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M
Nature Communications, 2023 The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex while also connecting it to different cargos.
Núria Gallisà-Suñé +8 more
doaj +1 more source
Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poorly understood. METHODS We integrated human genetics, transcriptomics, and functional studies to identify proteostasis network components involved ...
Samantha K. Swift +14 more
wiley +1 more source
Mitochondria and the Actin Cytoskeleton in Neurodegeneration
Cytoskeleton, Volume 83, Issue 4, Page 200-210, April 2026.ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli +3 more
wiley +1 more source
Regulation of dynein‐dynactin‐driven vesicular transport [PDF]
Traffic, 2017 Most of the long‐range intracellular movements of vesicles, organelles and other cargoes are driven by microtubule (MT)‐based molecular motors. Cytoplasmic dynein, a multisubunit protein complex, with the aid of dynactin, drives transport of a wide variety of cargoes towards the minus end of MTs.
openaire +2 more sources