Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport. [PDF]
PLoS Genetics, 2017 The microtubule-based motor dynein generates pulling forces for centrosome centration and mitotic spindle positioning in animal cells. How the essential dynein activator dynactin regulates these functions of the motor is incompletely understood. Here, we
Daniel J Barbosa +5 more
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Arl3 and LC8 regulate dissociation of dynactin from dynein [PDF]
Nature Communications, 2014 Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. However, the regulatory mechanism underlying release of dynactin bound cargoes from dynein motor remains largely unknown. Here we report that ADP-ribosylation factor-like 3 (Arl3) and dynein light chain LC8 induce dissociation of ...
Mingyue, Jin +4 more
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Dynein Light Chain 1 (DYNLT1) interacts with normal and oncogenic nucleoporins [PDF]
, 2013 The chimeric oncoprotein NUP98-HOXA9 results from the t(7;11)(p15;p15) chromosomal translocation and is associated with acute myeloid leukemia. It causes aberrant gene regulation and leukemic transformation through mechanisms that are not fully ...
Sarma, Nayan J, Yaseen, Nabeel R
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Dysfunction of dynactin 1 in motor neuron degeneration
Rinsho Shinkeigaku, 2013 Dynactin 1 is an axon motor protein regulating retrograde transport of various proteins and vesicles including autophagosome. We previously demonstrated that the expression levels of dynacin 1 are markedly reduced in spinal motor neurons of sporadic ALS patients.
Masahisa, Katsuno +3 more
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Regulation of Axonal Transport by Protein Kinases [PDF]
, 2015 The intracellular transport of organelles, proteins, lipids, and RNA along the axon is essential for neuronal function and survival. This process, called axonal transport, is mediated by two classes of ATP-dependent motors, kinesins, and cytoplasmic ...
Gibbs, KL, Greensmith, L, Schiavo, G
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Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome
EBioMedicine, 2017 Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra.
Yuka Hosaka +6 more
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Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
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Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease
Brain SciencesBackground/Objectives: Proper regulation of copper is essential for maintaining neuronal stability and is facilitated by several chaperone proteins, protecting cells from oxidative damage that would otherwise be caused by improperly regulated copper ions.
Nicholas Sanchez +5 more
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Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities? [PDF]
, 2017 Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells.
De Vos, K. +3 more
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USP45 and Spindly are part of the same complex implicated in cell migration [PDF]
, 2018 Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Conte, Claudia +3 more
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