Results 91 to 100 of about 9,409 (173)
Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poorly understood. METHODS We integrated human genetics, transcriptomics, and functional studies to identify proteostasis network components involved ...
Samantha K. Swift +14 more
wiley +1 more source
, 1998 We investigated whether the motor protein cytoplasmic dynein and dynactin, a protein complex thought to link dynein with vesicles, are present in rat renal collecting ducts and associated with aquaporin-2 (AQP2)-bearing vesicles.
Mark A. Knepper +5 more
core +1 more source
Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends
, 2009 Cytoplasmic dynein is a minus end-directed microtubule motor responsible for centripetal organelle movement and several aspects of chromosome segregation.
Tynan, Sharon H. +4 more
core
Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility [PDF]
, 2017 A key player in the intracellular trafficking network is cytoplasmic dynein, a protein complex that transports molecular cargo along microtubule tracks. It has been shown that vertebrate dynein’s movement becomes strikingly enhanced upon interacting with
Gabriel C. Lander +11 more
core +1 more source
Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome
EBioMedicine, 2017 Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra.
Yuka Hosaka +6 more
doaj +1 more source
Microtubule binding by dynactin is required for microtubule organization but not cargo transport [PDF]
, 2007 Dynactin links cytoplasmic dynein and other motors to cargo and is involved in organizing radial microtubule arrays. The largest subunit of dynactin, p150glued, binds the dynein intermediate chain and has an N-terminal microtubule-binding domain.
Comert Kural +13 more
core +1 more source
Physiological and Pathological Roles of Rab-Dynein-Dynactin Binding Adaptors
, 2023 Transport of different organelles along the Microtubule cytoskeleton is carried out mainly by motor proteins Dynein and Kinesin. The tubulin monomers in Microtubules are organized in such a way that the generate polarity (a minus and a plus end) that is ...
Quintremil, Sebastian
core +1 more source
, 2005 When cells enter mitosis the microtubule (MT) network undergoes a profound rearrangement, in part due to alterations in the MT nucleating and anchoring properties of the centrosome.
Nigg, Erich A. +2 more
core
PLoS ONE, 2019 Microtubules (Mts) are dynamic cytoskeleton structures that play a key role in vesicular transport. The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex.
Rodolfo M Ortiz Flores +3 more
doaj +1 more source
Conformational diversity of dynactin sidearm and domain organization of its subunit p150 [PDF]
, 2020 Dynactin is a principal regulator of the minus-end directed microtubule motor dynein. The sidearm of dynactin is essential for binding to microtubules and regulation of dynein activity. Although our understanding of the structure of the dynactin backbone
カズノ, サイコ +20 more
core