Results 91 to 100 of about 8,973 (210)

Functional Analysis of Dynactin and Cytoplasmic Dynein in Slow Axonal Transport

, 1996
The neuron moves protein and membrane from the cell body to the synapse and back via fast and slow axonal transport. Little is known about the mechanism of microtubule movement in slow axonal transport, although cytoplasmic dynein, the motor for ...
K. Kevin Pfister, Lewis P. Dabney, Bryce M. Paschal, James F. Dillman III, Erika L. F. Holzbaur, Sher Karki   +5 more
core   +1 more source

Conformational diversity of dynactin sidearm and domain organization of its subunit p150 [PDF]

, 2020
Dynactin is a principal regulator of the minus-end directed microtubule motor dynein. The sidearm of dynactin is essential for binding to microtubules and regulation of dynein activity. Although our understanding of the structure of the dynactin backbone
カズノ, サイコ, サクライ, タカシ, 柴田, 桂太朗, トヨシマ, ヨウコ, Shibata, Keitaro, ハタ, トモネ, 372290/profile-ja.html, Sakurai, Takashi, ムラヤマ, タカシ, Toyoshima, Yoko Y., Fujimura, Tsutomu, Kazuno, Saiko, サイトウ, ケイ, 1413, Saito, Kei, Murayama, Takashi, Kobayashi, Takuya, Hata, Tomone, シバタ, ケイタロウ, コバヤシ, タクヤ, フジムラ, ツトム   +20 more
core  

Formation of Spindle Poles by Dynein/Dynactin-Dependent Transport of Numa [PDF]

, 2000
NuMA is a large nuclear protein whose relocation to the spindle poles is required for bipolar mitotic spindle assembly. We show here that this process depends on directed NuMA transport toward microtubule minus ends powered by cytoplasmic dynein and its ...
William C. Earnshaw, Andreas Merdes, Don W. Cleveland, Cleveland, Don W, Kumiko Samejima, Heald, Rebecca, Rebecca Heald, Earnshaw, William C, Merdes, Andreas, Samejima, Kumiko   +9 more
core   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, Volume 13, Issue 14, 9 March 2026.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

N4BP2L1 interacts with dynactin and contributes to GLUT4 trafficking and glucose uptake in adipocytes

Journal of Diabetes Investigation, 2021
Aims/Introduction It was reported previously that N4bp2l1 expression increases in 3T3‐L1 cells in a differentiation‐dependent manner and N4bp2l1 knockdown suppresses adipocyte differentiation.
Kazuhisa Watanabe, Ayumi Matsumoto, Hidetoshi Tsuda, Sadahiko Iwamoto   +3 more
doaj   +1 more source

Regulation of dynein‐dynactin‐driven vesicular transport [PDF]

Traffic, 2017
Most of the long‐range intracellular movements of vesicles, organelles and other cargoes are driven by microtubule (MT)‐based molecular motors. Cytoplasmic dynein, a multisubunit protein complex, with the aid of dynactin, drives transport of a wide variety of cargoes towards the minus end of MTs.
openaire   +2 more sources

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

, 2014
Cytoplasmic dynein is a molecular motor that transports a large variety of cargoes (e.g., organelles, messenger RNAs, and viruses) along microtubules over long intracellular distances. The dynactin protein complex is important for dynein activity in vivo,
Huynh, Walter, McKenney, Richard J, Vale, Ronald D, Bhabha, Gira, Tanenbaum, Marvin E   +4 more
core   +1 more source

Tissue Proteomics of Feline Mammary Carcinoma: Differences in Protein Profiles Among Histological Grades Using Liquid Chromatography–Tandem Mass Spectrometry

Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 128-139, March 2026.
ABSTRACT Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis and therapy selection.
Pruettha Aruvornlop, Sekkarin Ploypetch, Walasinee Sakcamduang, Sirintra Sirivisoot, Tanit Kasantikul, Sittiruk Roytrakul, Narumon Phaonakrop, Nlin Arya   +7 more
wiley   +1 more source