Results 91 to 100 of about 7,885 (177)
Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
eLife, 2018 To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are pulled by membrane-associated cortical force-generating machinery.
Masako Okumura +3 more
doaj +1 more source
Trina Schroer: What’s cooking on dynactin [PDF]
Journal of Cell Biology, 2013 Schroer studies the composition and activity of dynactin.
openaire +1 more source
Towards a high‐resolution structure of dynactin
The FASEB Journal, 2006 Dynactin is a multisubunit protein complex necessary for the function of the cytoplasmic molecular motor, dynein, found in all eukaryotic cells. The complex binds the motor and then carries it along microtubules along with numerous and diverse cargo molecules.
Meiying Zheng +2 more
openaire +1 more source
Nature Communications, 2019 LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown.
Laura Pirovano +10 more
doaj +1 more source
Regulation of Dynactin by Palmitoylation
Neurons are large, complex cells that use a microtubule motor protein-based system for the fast transport of proteins and organelle cargo throughout long, complex projections. In output projections known as axons, cytoplasmic dynein transports cargo in the retrograde direction towards the cell body.
openaire +1 more source
CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation. [PDF]
Cell Repvan Toorn M +4 more
europepmc +1 more source
Roles of microtubules and LIS1 in dynein transport machinery assembly. [PDF]
NatureRao Q +4 more
europepmc +1 more source
Expression of Axonal Transport Proteins in Dopaminergic Neurons of the Substantia Nigra in Mouse Models of Preclinical and Clinical Stages of Parkinson's Disease. [PDF]
Int J Mol SciKolacheva A +8 more
europepmc +1 more source