Results 101 to 110 of about 8,973 (210)
Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease
Brain SciencesBackground/Objectives: Proper regulation of copper is essential for maintaining neuronal stability and is facilitated by several chaperone proteins, protecting cells from oxidative damage that would otherwise be caused by improperly regulated copper ions.
Nicholas Sanchez +5 more
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Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome
EBioMedicine, 2017 Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra.
Yuka Hosaka +6 more
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Dynactin Phosphorylation Is Modulated in Response to Cellular Effectors
Biochemical and Biophysical Research Communications, 1997 Reversible protein phosphorylation has been implicated in the regulation of organelle transport by cytoplasmic dynein. Motor function may be modulated directly by the phosphorylation of dynein or through the phosphorylation of an accessory factor. Dynactin binds to cytoplasmic dynein and is a required activator for dynein-driven vesicular motility.
P, Farshori, E L, Holzbaur
openaire +2 more sources
The interaction between cytoplasmic dynein and dynactin in intracellular transport
, 1997 Coordinated movement of organelles along the polarized array of microtubules is critical in diverse cellular processes such as mitosis, exocytosis, and axonal transport.
Karki, Sher Bahadur
core
, 2018 Shijun Wang,1 Qiaoqi Wang,2 Xiqian Zhang,3 Xiwen Liao,4 Guixian Wang,1 Long Yu,5 Wei Zhang,1 Quanbo Zhou,1 Shengyun Hu,1 Weitang Yuan1 1Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan ...
Zhang W +9 more
core
PLoS ONE, 2019 Microtubules (Mts) are dynamic cytoskeleton structures that play a key role in vesicular transport. The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex.
Rodolfo M Ortiz Flores +3 more
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Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
Frontiers in Neuroscience, 2015 The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
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Survival curves for SOD1 and dynactin-1 transgenic mice.
, 2022 Survival curves for transgenic C57BL6/J, SJL/J mice and their F2 cross with [A] the G93A human SOD1 transgene or [B] the G59S human dynactin-1 transgene.
Shannon Terek (12999834) +9 more
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RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs
eLife, 2018 Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
Mark A McClintock +6 more
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Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts
, 2008 Mitotic spindle orientation in polarized cells determines whether they divide symmetrically or asymmetrically. Moreover, regulated spindle orientation may be important for embryonic development, stem cell biology, and tumor growth. Drosophila neuroblasts
Doe, Chris Q., Siller, Karsten H.
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