PLoS ONE, 2019 Microtubules (Mts) are dynamic cytoskeleton structures that play a key role in vesicular transport. The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex.
Rodolfo M Ortiz Flores +3 more
doaj +1 more source
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
Frontiers in Neuroscience, 2015 The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj +1 more source
A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity [PDF]
, 2014 The timely delivery of membranous organelles and macromolecules to specific locations within the majority of eukaryotic cells depends on microtubule-based transport.
Abenza JF +55 more
core +3 more sources
RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs
eLife, 2018 Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
Mark A McClintock +6 more
doaj +1 more source
A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring [PDF]
, 2006 The anchoring of microtubules (MTs) to subcellular structures is critical for cell shape, polarity, and motility. In mammalian cells, the centrosome is a prominent MT anchoring structure.
Yan, Xiumin +2 more
core +1 more source
Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
eLife, 2018 To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are pulled by membrane-associated cortical force-generating machinery.
Masako Okumura +3 more
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A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
Nature Communications, 2020 Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport.
In-Gyun Lee +4 more
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The Effect of Dynactin Mutations upon Vesicle Trafficking in Living Cells using RNAi [PDF]
, 2010 UMKC Honors ...
Nienaber, Thomas
core
Miro-1 links mitochondria and microtubule dynein motors to control lymphocyte migration and polarity [PDF]
, 2014 The recruitment of leukocytes to sites of inflammation is crucial for a functional immune response. In the present work, we explored the role of mitochondria in lymphocyte adhesion, polarity, and migration.
Baixauli, Francesc +10 more
core +2 more sources
Regulation of Dynactin by Palmitoylation
, 2022 Neurons are large, complex cells that use a microtubule motor protein-based system for the fast transport of proteins and organelle cargo throughout long, complex projections. In output projections known as axons, cytoplasmic dynein transports cargo in the retrograde direction towards the cell body.
openaire +1 more source