Results 121 to 130 of about 8,973 (210)

Dynactin [PDF]

Current Biology, 2000
openaire   +3 more sources

Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct

, 1998
We investigated whether the motor protein cytoplasmic dynein and dynactin, a protein complex thought to link dynein with vesicles, are present in rat renal collecting ducts and associated with aquaporin-2 (AQP2)-bearing vesicles.
Mark A. Knepper, David Marples, Trina A. Schroer, Søren Nielsen, Nikolai Ahrens, Ann Taylor   +5 more
core   +1 more source

Insights on UNC-104-dynein/dynactin interactions and their implications on axonal transport in Caenorhabditis elegans

, 2019
Bidirectional cargo transport in neurons can be explained by two models: the "tug-of-war model" for short-range transport, in which several kinesin and dynein motors are bound to the same cargo but travel in opposing directions, and by the "motor ...
Ying‐Cheng Yen, Muniesh Muthaiyan Shanmugam, Wagner, Oliver, Peng, Yu-Fei, Muthaiyan Shanmugam, Muniesh, Yu‐Fei Peng, Bhan, Prerana, Klopfenstein, Dieter R., Chih‐Wei Chen, Chen, Chih-Wei, Yen, Ying-Cheng, Prerana Bhan, Oliver I. Wagner, Dieter R. Klopfenstein   +13 more
core   +1 more source

The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain

, 1999
Human EB1 is a highly conserved protein that binds to the carboxyl terminus of the human adenomatous polyposis coli (APC) tumor suppressor protein [1], a domain of APC that is commonly deleted in colorectal neoplasia [2].
Pellman, David, David Pellman, Barbara E. Bierer, Tirnauer, Jennifer S., Schuyler, Scott C., Berrueta, Lisbeth, Lisbeth Berrueta, Scott C. Schuyler, Jennifer S. Tirnauer, Bierer, Barbara E.   +9 more
core   +1 more source

A PIK3C3–Ankyrin-B–Dynactin pathway promotes axonal growth and multiorganelle transport

, 2014
Axon growth requires long-range transport of organelles, but how these cargoes recruit their motors and how their traffic is regulated are not fully resolved. In this paper, we identify a new pathway based on the class III PI3-kinase (PIK3C3), ankyrin-B (
Zhong, G., Zhuang, X., Damaris Nadia Lorenzo, Badea, A., Xiaowei Zhuang, Jiang He, Vann Bennett, Lorenzo, D.N., Hostettler, J., Davis, J., Alexandra Badea, He, J., Janell Hostettler, Bennett, V., Jonathan Davis, Guisheng Zhong   +15 more
core   +1 more source

Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome

, 2005
When cells enter mitosis the microtubule (MT) network undergoes a profound rearrangement, in part due to alterations in the MT nucleating and anchoring properties of the centrosome.
Barr, F. A., Casenghi, M., Nigg, Erich A., Nigg, E. A., Casenghi, Martina, Barr, Francis A.   +5 more
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Dynactin Subunit 1 [PDF]

, 2020
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Regulation of Dynactin by Palmitoylation

Neurons are large, complex cells that use a microtubule motor protein-based system for the fast transport of proteins and organelle cargo throughout long, complex projections. In output projections known as axons, cytoplasmic dynein transports cargo in the retrograde direction towards the cell body.
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CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation. [PDF]

Cell Rep
van Toorn M, Aslan M, Shintomi K, Yildiz A, Kiyomitsu T.   +4 more
europepmc   +1 more source

Biophysical and in vivo characterization of the dynein-dynactin interaction; implications for multiple modes of regulation

, 2010
Dynein is a large 1.2 MDa multimeric complex involved in fundamental cellular processes such as retrograde transport, cell division and positioning of organelles.
Siglin, Amanda E
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