Results 111 to 120 of about 14,978 (204)

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts

Developmental Biology, 2008
Mitotic spindle orientation in polarized cells determines whether they divide symmetrically or asymmetrically. Moreover, regulated spindle orientation may be important for embryonic development, stem cell biology, and tumor growth. Drosophila neuroblasts align their spindle along an apical/basal cortical polarity axis to self-renew an apical neuroblast
Siller, Karsten H., Doe, Chris Q.
openaire   +2 more sources

Narcissistic CLIP-170 also attracts dynactin

The Journal of Cell Biology, 2004
![Graphic][1] Dynactin (red) does not get to the plus end of microtubules (green) that lack CLIP-170 (blue).Self-love of a microtubule binding protein keeps it from its duties, according to Lansbergen et al. ( [page 1003][2]).
openaire   +2 more sources

Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

Nature Communications, 2019
LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown.
Laura Pirovano, Simone Culurgioni, Manuel Carminati, Andrea Alfieri, Silvia Monzani, Valentina Cecatiello, Chiara Gaddoni, Francesca Rizzelli, James Foadi, Sebastiano Pasqualato, Marina Mapelli   +10 more
doaj   +1 more source

Properties of tug-of-war model for cargo transport by molecular motors

, 2009
Molecular motors are essential components for the biophysical functions of the cell. Our current quantitative understanding of how multiple motors move along a single track is not complete; even though models and theories for single motor chemomechanics ...
J. Howard, Melanie J. I. Müller, Yunxin Zhang   +2 more
core   +1 more source

The Role of the Dynactin Complex in Intracellular Motility

, 1998
Dynactin is a multisubunit complex that binds to the minus-end-directed microtubule motor cytoplasmic dynein and may provide a link between the motor and its cargo. Results from genetic studies in Saccharomyces cerevisiae, Neurospora crassa, Aspergillus nidulans, and Drosophila have suggested that cytoplasmic dynein and dynactin function in the same ...
E A, Holleran, S, Karki, E L, Holzbaur
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Dynactin [PDF]

Current Biology, 2000
openaire   +3 more sources

Characterization of the Dynein-Dynactin Interaction [PDF]

, 2022
openaire   +2 more sources

Dynactin Subunit 1 [PDF]

, 2020
openaire   +1 more source

Adaptor-mediated recruitment of three dyneins to dynactin enhances force generation. [PDF]

Nat Cell Biol
Rao L, Liu X, Arnold M, Okada K, McKenney RJ, Stengel K, Sidoli S, Berger F, Gennerich A.   +8 more
europepmc   +1 more source

Cargo Recognition of Nesprin-2 by the Dynein Adapter Bicaudal D2 for a Nuclear Positioning Pathway That Is Important for Brain Development. [PDF]

Biochemistry
Rodriguez Castro ED, Putta S, Ali MY, Garcia Martin JM, Zhao X, Sylvain S, Trybus KM, Solmaz SR.   +7 more
europepmc   +1 more source