Results 111 to 120 of about 8,973 (210)
Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
eLife, 2018 To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are pulled by membrane-associated cortical force-generating machinery.
Masako Okumura +3 more
doaj +1 more source
A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
Nature Communications, 2020 Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport.
In-Gyun Lee +4 more
doaj +1 more source
Trina Schroer: What’s cooking on dynactin [PDF]
Journal of Cell Biology, 2013 Schroer studies the composition and activity of dynactin.
openaire +1 more source
The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes
, 2002 Dynactin is a multisubunit protein complex required for the activity of dynein in diverse intracellular motility processes, including membrane transport [1-3].
Short, B. +9 more
core +1 more source
Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends
, 2009 Cytoplasmic dynein is a minus end-directed microtubule motor responsible for centripetal organelle movement and several aspects of chromosome segregation.
Tynan, Sharon H. +4 more
core
Towards a high‐resolution structure of dynactin
The FASEB Journal, 2006 Dynactin is a multisubunit protein complex necessary for the function of the cytoplasmic molecular motor, dynein, found in all eukaryotic cells. The complex binds the motor and then carries it along microtubules along with numerous and diverse cargo molecules.
Meiying Zheng +2 more
openaire +1 more source
Nature Communications, 2019 LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown.
Laura Pirovano +10 more
doaj +1 more source
, 2008 Kinetochores bind microtubules laterally in a transient fashion and stably, by insertion of plus ends. These pathways may exist to carry out distinct tasks during different stages of mitosis and likely depend on distinct molecular mechanisms. On isolated
Gorbsky, Gary J. +4 more
core +1 more source
, 2005 Lis1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. Lis1 binds dynactin and the dynein motor complex, but the role of Lis1 in many dynein/dynactin-dependent ...
Karsten H. Siller +4 more
core +1 more source
The p25 subunit of the dynactin complex is required for dynein-early endosome interaction
, 2011 11 páginas, 5 figuras, 1 tabla -- PAGS nros. 1245-1255Cytoplasmic dynein transports various cellular cargoes including early endosomes, but how dynein is linked to early endosomes is unclear.
Abenza, Juan F. +11 more
core +1 more source