Results 141 to 150 of about 7,885 (177)
Non-cell autonomous autophagy in amyotrophic lateral sclerosis: A new promising target? [PDF]
Neurobiol DisRosso F +8 more
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NUDC Is Critical for Mitosis and Postmitotic Cell Maintenance Through Its Modulation of Dynein and Actin Cytoskeletal Reorganization. [PDF]
Adv Exp Med BiolGarner MA, Gross AK.
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Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria. [PDF]
Nat CommunEli S +21 more
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p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation [PDF]
Journal of Biological Chemistry, 2018 Cytoplasmic dynein binds its cargoes via the dynactin complex and cargo adapters, and the dynactin pointed-end protein p25 is required for dynein-dynactin binding to the early endosomal dynein adapter HookA (Hook in the fungus Aspergillus nidulans). However, it is unclear whether the HookA-dynein-dynactin interaction requires p27, another pointed-end ...
, Xin Xiang, Rongde Qiu
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Structure and function of dynactin
Seminars in Cell and Developmental Biology, 1996 Abstract Dynactin is a 1·2 mDa protein complex initially isolated as an activator of cytoplasmic dynein-driven vesicle movementin vitro. Genetic studies have verified that dynactin participates in dynein-based transport events as varied as nuclear localization and axonal transport.
Trina Schroer
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Dynactin Function in Mitotic Spindle Positioning [PDF]
Traffic, 2008 Dynactin is a multisubunit protein complex necessary for dynein function. Here, we investigated the function of dynactin in budding yeast. Loss of dynactin impaired movement and positioning of the mitotic spindle, similar to loss of dynein. Dynactin subunits required for function included p150Glued, dynamitin, actin‐related protein (Arp) 1 and p24 ...
John Cooper, Jeffrey Moore
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Dynactin is essential for growth cone advance
Biochemical and Biophysical Research Communications, 2008Dynactin is a multi-subunit complex that serves as a critical cofactor of the microtubule motor cytoplasmic dynein. We previously identified dynactin in the nerve growth cone. However, the function of dynactin in the growth cone is still unclear. Here we show that dynactin in the growth cone is required for constant forward movement of the growth cone.
Kohtaro Takei +2 more
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The structure of the dynactin complex and its interaction with dynein [PDF]
Science, 2015 Making a molecular motor fit for purpose Dynactin is an essential cofactor of the microtubule motor, cytoplasmic dynein. Dynactin contains 23 subunits built around a short filament of an actin-related protein (Arp1).
Kai Zhang, Andrew Carter, C V Robinson
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Dynactin is involved in Lewy body pathology
Neuropathology, 2018Dynactin forms a protein complex with dynein that retrogradely transports cargo along microtubules. Dysfunction of this dynein‐dynactin complex causes several neurodegenerative diseases such as Perry syndrome, motor neuron diseases and progressive supranuclear palsy.
Masahiro Shijo +2 more
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Annual Review of Cell and Developmental Biology, 2004
▪ Abstract Dynactin is a multisubunit protein complex that is required for most, if not all, types of cytoplasmic dynein activity in eukaryotes. Dynactin binds dynein directly and allows the motor to traverse the microtubule lattice over long distances.
openaire +2 more sources
▪ Abstract Dynactin is a multisubunit protein complex that is required for most, if not all, types of cytoplasmic dynein activity in eukaryotes. Dynactin binds dynein directly and allows the motor to traverse the microtubule lattice over long distances.
openaire +2 more sources