Results 81 to 90 of about 7,885 (177)

The Impact of Chemical Toxicants and Air Pollutants on Neurodegenerative Disorders and Their Underlying Potential Mechanisms: A Literature Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Neurodegenerative disorders are marked by progressive deterioration of neurons, affecting cognitive, memory, and motor functions. This decline creates substantial personal and social challenges, making early identification of risk factors essential for effective intervention.
Sameeha Fatima Khan, Warda Rasool, Muhammad Hamza Khan, Ganesh Kumar, Azka Ijaz, Maryam Amjad, Mahin Qudeer Sheikh, Shree Rath, Digbijay Kunwar, Anum Akbar   +9 more
wiley   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, Volume 13, Issue 14, 9 March 2026.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease

Brain Sciences
Background/Objectives: Proper regulation of copper is essential for maintaining neuronal stability and is facilitated by several chaperone proteins, protecting cells from oxidative damage that would otherwise be caused by improperly regulated copper ions.
Nicholas Sanchez, Danilo S. Boskovic, Charles W. Diamond, Timothy W. Lyons, Salvador Soriano, Wolff M. Kirsch   +5 more
doaj   +1 more source

Dynactin Phosphorylation Is Modulated in Response to Cellular Effectors

Biochemical and Biophysical Research Communications, 1997
Reversible protein phosphorylation has been implicated in the regulation of organelle transport by cytoplasmic dynein. Motor function may be modulated directly by the phosphorylation of dynein or through the phosphorylation of an accessory factor. Dynactin binds to cytoplasmic dynein and is a required activator for dynein-driven vesicular motility.
P, Farshori, E L, Holzbaur
openaire   +2 more sources

Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

EBioMedicine, 2017
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra.
Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori   +6 more
doaj   +1 more source

The role of microtubules and the dynein/dynactin motor complex of host cells in the biogenesis of the Coxiella burnetii-containing vacuole.

PLoS ONE, 2019
Microtubules (Mts) are dynamic cytoskeleton structures that play a key role in vesicular transport. The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex.
Rodolfo M Ortiz Flores, Jesús S Distel, Milton O Aguilera, Walter Berón   +3 more
doaj   +1 more source

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders

Frontiers in Neuroscience, 2015
The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj   +1 more source

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

eLife, 2018
Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
Mark A McClintock, Carly I Dix, Christopher M Johnson, Stephen H McLaughlin, Rory J Maizels, Ha Thi Hoang, Simon L Bullock   +6 more
doaj   +1 more source

A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner

Nature Communications, 2020
Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport.
In-Gyun Lee, Sydney E. Cason, Saif S. Alqassim, Erika L. F. Holzbaur, Roberto Dominguez   +4 more
doaj   +1 more source