Results 81 to 90 of about 14,978 (204)
A mathematical understanding of how cytoplasmic dynein walks on microtubules [PDF]
, 2018 Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles, a mechanical model
Hafezparast, M, Madzvamuse, A, Trott, L
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Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration [PDF]
Proceedings of the National Academy of Sciences, 2009 Neurodegenerative disease in humans and mice can be caused by mutations affecting the microtubule motor dynein or its biochemical regulator, dynactin, a multiprotein complex required for dynein function ( 1 – 4 )
Jeffrey K, Moore +2 more
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BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M
Nature Communications, 2023 The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex while also connecting it to different cargos.
Núria Gallisà-Suñé +8 more
doaj +1 more source
eLife, 2016 Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
Lindsey Seldin +2 more
doaj +1 more source
Mechanisms of spindle positioning. [PDF]
, 2013 Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions that are crucial for animal development and oocyte maturation, respectively.
McNally, Francis J
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Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity [PDF]
Journal of Neurochemistry, 2012 J. Neurochem. (2012) 122, 162–174.AbstractGlutamate excitotoxicity causes neuronal dysfunction and degeneration. It is implicated in chronic disorders, including Alzheimer’s disease, and in acute CNS insults such as ischemia. These disorders share prominent morphological features, including axon degeneration and cell body death.
Takeshi, Fujiwara +3 more
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Journal of Diabetes Investigation, 2021 Aims/Introduction It was reported previously that N4bp2l1 expression increases in 3T3‐L1 cells in a differentiation‐dependent manner and N4bp2l1 knockdown suppresses adipocyte differentiation.
Kazuhisa Watanabe +3 more
doaj +1 more source
Intracellular transport driven by cytoskeletal motors: General mechanisms and defects
, 2015 Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large.
Appert-Rolland, Cecile +2 more
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Neurobiology of axonal transport defects in motor neuron diseases: opportunities for translational research? [PDF]
, 2017 Intracellular trafficking of cargoes is an essential process to maintain the structure and function of all mammalian cell types, but especially of neurons because of their extreme axon/dendrite polarisation.
De Vos, Kurt J, Hafezparast, Majid
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Structural Dynamics and Multiregion Interactions in Dynein-Dynactin Recognition [PDF]
Journal of Biological Chemistry, 2011 Cytoplasmic dynein is a 1.2-MDa multisubunit motor protein complex that, together with its activator dynactin, is responsible for the majority of minus end microtubule-based motility. Dynactin targets dynein to specific cellular locations, links dynein to cargo, and increases dynein processivity.
Jessica L, Morgan +2 more
openaire +2 more sources