Results 81 to 90 of about 8,973 (210)
Frontiers in Cell and Developmental Biology, 2016 Unexpectedly, members of the Rab VI subfamily exhibit considerable variation in their effects on Golgi organization and trafficking. By fluorescence microscopy, neither depletion nor overexpression of the GDP-locked form of Rab6a/a’, the first trans ...
Shijie eLiu +4 more
doaj +1 more source
Dysfunction of dynactin 1 in motor neuron degeneration
Rinsho Shinkeigaku, 2013 Dynactin 1 is an axon motor protein regulating retrograde transport of various proteins and vesicles including autophagosome. We previously demonstrated that the expression levels of dynacin 1 are markedly reduced in spinal motor neurons of sporadic ALS patients.
Katsuno, Masahisa +3 more
openaire +3 more sources
The Interaction between Cytoplasmic Dynein and Dynactin is Required for Fast Axonal Transport
, 1997 Fast axonal transport is characterized by the bidirectional, microtubule-based movement of membranous organelles. Cytoplasmic dynein is necessary but not sufficient for retrograde transport directed from the synapse to the cell body.
Waterman-Storer, Clare M +12 more
core +1 more source
Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poorly understood. METHODS We integrated human genetics, transcriptomics, and functional studies to identify proteostasis network components involved ...
Samantha K. Swift +14 more
wiley +1 more source
Diet and cell size both affect queen-worker differentiation through DNA methylation in honey bees (Apis mellifera, Apidae). [PDF]
PLoS ONE, 2011 Young larvae of the honey bee (Apis mellifera) are totipotent; they can become either queens (reproductives) or workers (largely sterile helpers). DNA methylation has been shown to play an important role in this differentiation. In this study, we examine
Yuan Yuan Shi +5 more
doaj +1 more source
Mitochondria and the Actin Cytoskeleton in Neurodegeneration
Cytoskeleton, Volume 83, Issue 4, Page 200-210, April 2026.ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli +3 more
wiley +1 more source
eLife, 2016 Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
Lindsey Seldin +2 more
doaj +1 more source
BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M
Nature Communications, 2023 The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex while also connecting it to different cargos.
Núria Gallisà-Suñé +8 more
doaj +1 more source
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin
, 2022 Cytoplasmic Dynein 1, or Dynein, is a microtubule minus end–directed motor. Dynein motility requires Dynactin and a family of activating adaptors that stabilize the Dynein–Dynactin complex and promote regulated interactions with cargo in space and time ...
Girbig, M. +24 more
core +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Neurodegenerative disorders are marked by progressive deterioration of neurons, affecting cognitive, memory, and motor functions. This decline creates substantial personal and social challenges, making early identification of risk factors essential for effective intervention.
Sameeha Fatima Khan +9 more
wiley +1 more source