Results 81 to 90 of about 9,409 (173)

Identification of Rab41/6d effectors provides an explanation for the differential effects of Rab41/6d and Rab6a/a' on Golgi organization

Frontiers in Cell and Developmental Biology, 2016
Unexpectedly, members of the Rab VI subfamily exhibit considerable variation in their effects on Golgi organization and trafficking. By fluorescence microscopy, neither depletion nor overexpression of the GDP-locked form of Rab6a/a’, the first trans ...
Shijie eLiu, Waqar eMajeed, Tetyana eKudlyk, Vladimir eLupashin, Brian eStorrie   +4 more
doaj   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, Volume 183, Issue 16, Page 5120-5147, August 2026.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control

, 2005
Lis1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. Lis1 binds dynactin and the dynein motor complex, but the role of Lis1 in many dynein/dynactin-dependent ...
Karsten H. Siller, Ruth Steward, Madeline Serr, Chris Q. Doe, Tom S. Hays   +4 more
core   +1 more source

NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

eLife, 2016
Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
Lindsey Seldin, Andrew Muroyama, Terry Lechler   +2 more
doaj   +1 more source

Diet and cell size both affect queen-worker differentiation through DNA methylation in honey bees (Apis mellifera, Apidae). [PDF]

PLoS ONE, 2011
Young larvae of the honey bee (Apis mellifera) are totipotent; they can become either queens (reproductives) or workers (largely sterile helpers). DNA methylation has been shown to play an important role in this differentiation. In this study, we examine
Yuan Yuan Shi, Zachary Y Huang, Zhi Jiang Zeng, Zi Long Wang, Xiao Bo Wu, Wei Yu Yan   +5 more
doaj   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

RNA interference in crop protection: opportunities and challenges during the transition to commercialization

Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.
RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi, Anna Narduzzo, Alessandra Di Canito, Francesco Favaretto, Luca Nerva, Walter Chitarra, Lucia Bologna, Jacopo Bacenetti, Giuliana Maddalena, Simona Masiero, Ileana Vigentini, Gabriella De Lorenzis, Silvia Laura Toffolatti   +12 more
wiley   +1 more source

Survival curves for SOD1 and dynactin-1 transgenic mice.

, 2022
Survival curves for transgenic C57BL6/J, SJL/J mice and their F2 cross with [A] the G93A human SOD1 transgene or [B] the G59S human dynactin-1 transgene.
Shannon Terek (12999834), Laura Hennessy (13804524), Nicole Caccavo (13804527), Roger B. Sher (13804521), Vivek M. Philip (264868), Elizabeth A. Blankenhorn (13804533), Terry D. Heiman-Patterson (13804518), Frank Bearoff (691556), Gregory A. Cox (13804530), Guillermo M. Alexander (13804515)   +9 more
core   +1 more source

Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease

Brain Sciences
Background/Objectives: Proper regulation of copper is essential for maintaining neuronal stability and is facilitated by several chaperone proteins, protecting cells from oxidative damage that would otherwise be caused by improperly regulated copper ions.
Nicholas Sanchez, Danilo S. Boskovic, Charles W. Diamond, Timothy W. Lyons, Salvador Soriano, Wolff M. Kirsch   +5 more
doaj   +1 more source

Different Paths, Similar Pressures: Divergent Drivers of Genetic Diversity Despite Convergent Genomic Signatures of Selection in Response to Urban Intensity in Two Oligolectic Bee Species

Molecular Ecology, Volume 35, Issue 9, May 2026.
ABSTRACT Urbanisation is a pervasive form of anthropogenic environmental change and a driver of contemporary evolution. Yet, it remains unclear how demographic processes and environmentally associated genomic variation shape genomic patterns in cities and whether these responses depend on species‐specific ecological traits.
Lucie M. Baltz, Hanna Gardein, Henri Greil, Robert J. Paxton, Panagiotis Theodorou   +4 more
wiley   +1 more source