Results 51 to 60 of about 8,973 (210)
Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3 [PDF]
, 2016 Metazoan cytoplasmic dynein moves processively along microtubules with the aid of dynactin and an adaptor protein that joins dynein and dynactin into a stable ternary complex.
Courtney M. Schroeder +3 more
core +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
Advanced Science, EarlyView.Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu +9 more
wiley +1 more source
Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex
eLife, 2018 We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein ...
Thomas E Sladewski +7 more
doaj +1 more source
RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
Nature Communications, 2022 Lysosomes move along microtubule tracks, and Arl8b is known to stimulate their anterograde transport. Here, the authors identified RUFY3 as an Arl8b effector that interacts with dynein-dynactin to drive retrograde transport and perinuclear lysosome ...
Gaurav Kumar +7 more
doaj +1 more source
Dynactin: Coordinating Motors with Opposite Inclinations [PDF]
Current Biology, 2003 In eukaryotic cells, many organelles are transported bidirectionally along microtubules by kinesin and dynein. These opposite-polarity motors appear to be coordinated to avoid interfering with each other's function. New work has provided the first molecular insight into how such coordination might occur.
openaire +2 more sources
Dynein/Dynactin modulates neurite formation.
, 2013 A: Representative microscopic images of P19 cells acquired in the primary screen, transfected with neurogenic transcription factor NeuroD2 and 4pmol of siRNA oligonucleotide mixtures targeting Dynein/Dynactin subunits.
Leif Dehmelt (7132) +2 more
core +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
The Role of the Dynactin Complex in Intracellular Motility
, 1998 Dynactin is a multisubunit complex that binds to the minus-end-directed microtubule motor cytoplasmic dynein and may provide a link between the motor and its cargo. Results from genetic studies in Saccharomyces cerevisiae, Neurospora crassa, Aspergillus nidulans, and Drosophila have suggested that cytoplasmic dynein and dynactin function in the same ...
E A, Holleran, S, Karki, E L, Holzbaur
openaire +2 more sources
Dynactin Is Required for Transport Initiation from the Distal Axon
, 2012 SummaryDynactin is a required cofactor for the minus-end-directed microtubule motor cytoplasmic dynein. Mutations within the highly conserved CAP-Gly domain of dynactin cause neurodegenerative disease.
Moughamian, Armen J. +1 more
core +1 more source