Results 51 to 60 of about 14,978 (204)
Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin. [PDF]
, 2019 Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to a cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor.
Blanchard, Scott C +6 more
core
Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila [PDF]
, 1999 Glued1 (Gl1) mutants produce a truncated protein that acts as a poison subunit and disables the cytoplasmic retrograde motor dynein. Heterozygous mutants have axonal defects in the adult eye and the nervous system.
Allen, Marcus James +5 more
core +1 more source
RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
Nature Communications, 2022 Lysosomes move along microtubule tracks, and Arl8b is known to stimulate their anterograde transport. Here, the authors identified RUFY3 as an Arl8b effector that interacts with dynein-dynactin to drive retrograde transport and perinuclear lysosome ...
Gaurav Kumar +7 more
doaj +1 more source
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C. [PDF]
, 2019 The unidirectional and opposite-polarity microtubule-based motors, dynein and kinesin, drive long-distance intracellular cargo transport. Cellular observations suggest that opposite-polarity motors may be coupled.
Dickey, Andrea M +7 more
core
Homolog pairing during meiosis : dyneins on the move [PDF]
, 2010 Meiosis is a specialized form of cell division that generates haploid gametes from diploid cells. This is achieved by having 1 round of DNA replication followed by 2 rounds of nuclear division.
Arumugam, Prakash
core +1 more source
Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex
eLife, 2018 We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein ...
Thomas E Sladewski +7 more
doaj +1 more source
RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
Nature Communications, 2022 Organellar transport is carefully regulated, and endolysosome localized ARL8 is important for kinesin recruitment and anterograde movement. Here, the authors show that RUFY3 and RUFY4 promote retrograde transport of endolysosomes by mediating interaction
Tal Keren-Kaplan +6 more
doaj +1 more source
Emerging Trends of Nanotechnology towards Picotechnology: Energy and Biomolecules [PDF]
, 2010 In nature, metal oxide particles display their existence at the level of picomolecules in solution state and bioactive states in the body. We present evidence of picomolar behavior of molecules different than nanomolar behavior of particles.
Avdhesh Sharma +2 more
core +2 more sources
Dynactin Is Required for Microtubule Anchoring at Centrosomes [PDF]
The Journal of Cell Biology, 1999 The multiprotein complex, dynactin, is an integral part of the cytoplasmic dynein motor and is required for dynein-based motility in vitro and in vivo. In living cells, perturbation of the dynein–dynactin interaction profoundly blocks mitotic spindle assembly, and inhibition or depletion of dynein or dynactin from meiotic or mitotic cell extracts ...
N J, Quintyne +5 more
openaire +2 more sources
Nature Communications, 2023 The mechanisms of microtubule-based mitochondrial transport remain poorly understood. Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to ...
John T. Canty +4 more
doaj +1 more source