Results 31 to 40 of about 7,885 (177)

Mutant dynactin in motor neuron disease [PDF]

Nature Genetics, 2003
Impaired axonal transport in motor neurons has been proposed as a mechanism for neuronal degeneration in motor neuron disease. Here we show linkage of a lower motor neuron disease to a region of 4 Mb at chromosome 2p13. Mutation analysis of a gene in this interval that encodes the largest subunit of the axonal transport protein dynactin showed a single
Imke, Puls, Catherine, Jonnakuty, Bernadette H, LaMonte, Erika L F, Holzbaur, Mariko, Tokito, Eric, Mann, Mary Kay, Floeter, Kimberly, Bidus, Dennis, Drayna, Shin J, Oh, Robert H, Brown, Christy L, Ludlow, Kenneth H, Fischbeck   +12 more
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Characterization of the p22 Subunit of Dynactin Reveals the Localization of Cytoplasmic Dynein and Dynactin to the Midbody of Dividing Cells [PDF]

The Journal of Cell Biology, 1998
Dynactin, a multisubunit complex that binds to the microtubule motor cytoplasmic dynein, may provide a link between dynein and its cargo. Many subunits of dynactin have been characterized, elucidating the multifunctional nature of this complex. Using a dynein affinity column, p22, the smallest dynactin subunit, was isolated and microsequenced.
S, Karki, B, LaMonte, E L, Holzbaur
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Cargo-Mediated Activation of Cytoplasmic Dynein in vivo

Frontiers in Cell and Developmental Biology, 2020
Cytoplasmic dynein-1 is a minus-end-directed microtubule motor that transports a variety of cargoes including early endosomes, late endosomes and other organelles.
Xin Xiang, Rongde Qiu
doaj   +1 more source

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

eLife, 2017
The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach, Andal Murthy, Mark A McClintock, Carly I Dix, Ruta Zalyte, Ha Thi Hoang, Simon L Bullock   +6 more
doaj   +1 more source

ZW10 Helps Recruit Dynactin and Dynein to the Kinetochore [PDF]

The Journal of Cell Biology, 1998
Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores. Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar ...
Starr, Daniel A, Williams, Byron C, Hays, Thomas S, Goldberg, Michael L   +3 more
openaire   +4 more sources

Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1

eLife, 2018
Cortical dynein generates pulling forces via microtubule (MT) end capture-shrinkage and lateral MT sliding mechanisms. In Saccharomyces cerevisiae, the dynein attachment molecule Num1 interacts with endoplasmic reticulum (ER) and mitochondria to ...
Safia Omer, Samuel R Greenberg, Wei-Lih Lee   +2 more
doaj   +1 more source

Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. [PDF]

PLoS ONE, 2013
Cytoplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling and cell division. The principal subunits that mediate this interaction are the dynein intermediate chain (IC) and the dynactin p150(Glued); however ...
Amanda E Siglin, Shangjin Sun, Jeffrey K Moore, Sarah Tan, Martin Poenie, James D Lear, Tatyana Polenova, John A Cooper, John C Williams   +8 more
doaj   +1 more source

Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

eLife, 2023
Kazrin is a protein widely expressed in vertebrates whose depletion causes a myriad of developmental defects, in part derived from altered cell adhesion and migration, as well as failure to undergo epidermal to mesenchymal transition.
Ines Hernandez-Perez, Javier Rubio, Adrian Baumann, Henrique Girao, Miriam Ferrando, Elena Rebollo, Anna M Aragay, María Isabel Geli   +7 more
doaj   +1 more source

Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson's disease

Brazilian Journal of Medical and Biological Research
Axons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of Parkinson's disease (PD), with axonal degeneration preceding the loss of cell bodies.
Yongmei Wu, Qiang Guo, Jinfan Gan, Linghan Duan, Haixia Zhao, Haoran Tai, Chan Yang, Yunzhu Li, Zhen Xu, Yue Yao, Zheng Nie, Ming Yang, Shurong Li, Jun Li, Bingyin Su   +14 more
doaj   +1 more source

Analysis of the Dynein-Dynactin Interaction In Vitro and In Vivo [PDF]

Molecular Biology of the Cell, 2003
Cytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context.
Stephen J, King, Christa L, Brown, Kerstin C, Maier, Nicholas J, Quintyne, Trina A, Schroer   +4 more
openaire   +2 more sources