Results 31 to 40 of about 9,409 (173)

Structural basis for cytoplasmic dynein-1 regulation by Lis1

eLife, 2022
The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor ...
John P Gillies, Janice M Reimer, Eva P Karasmanis, Indrajit Lahiri, Zaw Min Htet, Andres E Leschziner, Samara L Reck-Peterson   +6 more
doaj   +1 more source

Bicd2, Dynactin, And Lis1 Cooperate In Regulating Dynein Recruitment To Cellular Structures [PDF]

, 2012
Cytoplasmic dynein is the major microtubule minus-end-directed cellular motor. Most dynein activities require dynactin, but the mechanisms regulating cargo-dependent dynein-dynactin interaction are poorly understood.
Razafsky, David S., Grigoriev, Ilya, Serra-Marques, Andrea, Splinter, Daniël, Schlager, Max A.   +4 more
core   +2 more sources

The Interaction between Cytoplasmic Dynein and Dynactin is Required for Fast Axonal Transport [PDF]

, 1997
Fast axonal transport is characterized by the bidirectional, microtubule-based movement of membranous organelles. Cytoplasmic dynein is necessary but not sufficient for retrograde transport directed from the synapse to the cell body.
Waterman-Storer, Clare M, Weiss, Dieter G., Karki, Sher B., Karki, Sher B, Holzbaur, Erika L.F., Weiss, Dieter G, Kunetsov, Sergei A., Tabb, Joel S, Kuznetsov, Sergei A, Tabb, Joel S., Waterman-Storer, Clare M., Langford, George M, Holzbaur, Erika L. F.   +12 more
core   +2 more sources

The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly

Scientific Reports, 2018
The minus-end-directed microtubule motor cytoplasmic dynein requires the dynactin complex for in vivo functions. The backbone of the vertebrate dynactin complex is the Arp1 (actin-related protein 1) mini-filament whose barbed end binds to the ...
Jun Zhang, Rongde Qiu, Xin Xiang
doaj   +1 more source

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

eLife, 2017
Mitochondrial transport in axons is critical for neural circuit health and function. While several proteins have been found that modulate bidirectional mitochondrial motility, factors that regulate unidirectional mitochondrial transport have been harder ...
Catherine M Drerup, Amy L Herbert, Kelly R Monk, Alex V Nechiporuk   +3 more
doaj   +1 more source

Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic. [PDF]

, 2008
Alpha-epithelial catenin (E-catenin) is an important cell-cell adhesion protein. In this study, we show that alpha-E-catenin also regulates intracellular traffic by binding to the dynactin complex component dynamitin.
Valeri Vasioukhin, Wen-Hui Lien, Lien, Wen-Hui, Vladimir I. Gelfand, Gelfand, Vladimir I, Vasioukhin, Valeri   +5 more
core   +1 more source

New insights into the mechanism of dynein motor regulation by lissencephaly-1

eLife, 2020
Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
Steven M Markus, Matthew G Marzo, Richard J McKenney   +2 more
doaj   +1 more source

Spindly is required for rapid migration of human cells

Biology Open, 2018
Dynein is the sole processive minus-end-directed microtubule motor found in animals. It has roles in cell division, membrane trafficking, and cell migration.
Claudia Conte, Michelle A. Baird, Michael W. Davidson, Eric R. Griffis   +3 more
doaj   +1 more source

Exploring protein - protein interaction in cell physiology by reviewing the role of dynein-dynactin interaction as a representative example

Studia Universitatis Babeș-Bolyai. Biologia, 2023
Protein-protein interactions are essential for the normal function of cells and are involved in various cellular processes. These interactions can occur through a variety of mechanisms, including hydrogen bonding, ionic interactions, and hydrophobic ...
Neelabh Datta
doaj   +1 more source

Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs [PDF]

, 2013
Microtubule-based transport mediates the sorting and dispersal of many cellular components and pathogens. However, the mechanisms by which motor complexes are recruited to and regulated on different cargos remain poorly understood.
Beat Suter, Dzhindzhev, NS, Suter, Beat, Elaine Stephens, Nikola S. Dzhindzhev, Simon L. Bullock, Soundararajan, HC, Ohkura, H, Carly I. Dix, Dix, Carly I, Bullock, SL, Harish Chandra Soundararajan, Farida Begum, Hiroyuki Ohkura, Stephens, E, Begum, F, Dix, Carly I., Begum, Farida, Soundararajan, Harish Chandra, Ohkura, Hiroyuki, Bullock, Simon L., Dzhindzhev, Nikola S., Stephens, Elaine   +22 more
core   +2 more sources