Results 31 to 40 of about 14,978 (204)
The role of motor proteins in endosomal sorting [PDF]
, 2011 Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Stephens, DJ
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Dynactin Enhances the Processivity of Kinesin‐2 [PDF]
Traffic, 2006 Kinesin‐2 is a major microtubule‐based motor in most cell types. Its in vitro motile properties have been analyzed extensively and been found to differ considerably from kinesin‐1. Although recombinant kinesin‐2 heterodimers exhibit processive movement, the processivity of the native kinesin‐2 holoenzyme has never been evaluated. Kinesin‐2 can interact
Matthew A, Berezuk, Trina A, Schroer
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Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking [PDF]
Scientific Reports, 2017 AbstractThe transmembrane prostate androgen-induced protein (TMEPAI) has been reported to be elevated in various tumor cells, is localized to the lysosome and promotes lysosome stability. The molecular mechanism of TMEPAI trafficking however to the lysosome is unknown.
Shenheng Luo +5 more
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Cargo-Mediated Activation of Cytoplasmic Dynein in vivo
Frontiers in Cell and Developmental Biology, 2020 Cytoplasmic dynein-1 is a minus-end-directed microtubule motor that transports a variety of cargoes including early endosomes, late endosomes and other organelles.
Xin Xiang, Rongde Qiu
doaj +1 more source
Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
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Dynactin: Coordinating Motors with Opposite Inclinations [PDF]
Current Biology, 2003 In eukaryotic cells, many organelles are transported bidirectionally along microtubules by kinesin and dynein. These opposite-polarity motors appear to be coordinated to avoid interfering with each other's function. New work has provided the first molecular insight into how such coordination might occur.
openaire +2 more sources
DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]
, 2019 T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
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The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]
, 2010 Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet +74 more
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Lissencephaly-1 is a context-dependent regulator of the human dynein complex
eLife, 2017 The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach +6 more
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Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes
eLife, 2023 Kazrin is a protein widely expressed in vertebrates whose depletion causes a myriad of developmental defects, in part derived from altered cell adhesion and migration, as well as failure to undergo epidermal to mesenchymal transition.
Ines Hernandez-Perez +7 more
doaj +1 more source