Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam. [PDF]
PLoS ONE, 2008 BACKGROUND:Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained.
Jacob Shun-Jen Yang +2 more
doaj +3 more sources
Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1. [PDF]
Front Mol BiosciCytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing crucial roles in intracellular organisation and cell division.
Kumawat A.
europepmc +2 more sources
Characterization of the Dynein-Dynactin Interaction [PDF]
, 2022 In eukaryotic cells many biological processes like cell division, the distribution of vesicles and organelles require the dynamic rearrangement of molecules and cellular components.
Findeisen, Peggy
openaire +3 more sources
Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport. [PDF]
BioessaysDirectional intracellular cargo transport is traditionally attributed to motor stepping along stationary microtubule (MT) tracks. We propose a complementary mechanism of cargo co‐migration with moving MTs. This mode requires cargo–MT tethering and directed MT motion.
Zhou C, Kengaku M.
europepmc +2 more sources
Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking [PDF]
Scientific Reports, 2017 AbstractThe transmembrane prostate androgen-induced protein (TMEPAI) has been reported to be elevated in various tumor cells, is localized to the lysosome and promotes lysosome stability. The molecular mechanism of TMEPAI trafficking however to the lysosome is unknown.
Shenheng Luo +5 more
openaire +3 more sources
Perry Disease: Concept of a New Disease and Clinical Diagnostic Criteria [PDF]
Journal of Movement Disorders, 2021 Perry disease is a hereditary neurodegenerative disease with autosomal dominant inheritance. It is characterized by parkinsonism, psychiatric symptoms, unexpected weight loss, central hypoventilation, and transactive-response DNA-binding protein of 43kD (
Yoshio Tsuboi +2 more
doaj +1 more source
Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein
Nature Communications, 2023 Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-terminus and the ...
Kyoko Okada +6 more
doaj +1 more source
Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid. [PDF]
PLoS ONE, 2011 The mitotic checkpoint functions to ensure accurate chromosome segregation by regulating the progression from metaphase to anaphase. Once the checkpoint has been satisfied, it is inactivated in order to allow the cell to proceed into anaphase and ...
Jakub K Famulski +3 more
doaj +1 more source
Activation and regulation of the dynein-dynactin-NuMA complex. [PDF]
Nat Chem BiolAbstract During cell division, NuMA orchestrates the focusing of microtubule minus-ends in spindle poles and cortical force generation on astral microtubules by interacting with dynein motors, microtubules, and other cellular factors. Here, we used in vitro reconstitution, cryo-electron microscopy, and live cell imaging to understand ...
Aslan M +10 more
europepmc +2 more sources
TRAPPC9 mediates the interaction between p150 and COPII vesicles at the target membrane. [PDF]
PLoS ONE, 2012 The transport of endoplasmic reticulum (ER)-derived COPII vesicles toward the ER-Golgi intermediate compartment (ERGIC) requires cytoplasmic dynein and is dependent on microtubules. p150(Glued), a subunit of dynactin, has been implicated in the transport
Min Zong +7 more
doaj +1 more source