Results 71 to 80 of about 2,739 (166)
Lis1 is an initiation factor for dynein-driven organelle transport [PDF]
Journal of Cell Biology, 2012 The molecular motor cytoplasmic dynein is responsible for most minus-end–directed, microtubule-based transport in eukaryotic cells. It is especially important in neurons, where defects in microtubule-based motility have been linked to neurological diseases. For example, lissencephaly is caused by mutations in the dynein-associated protein Lis1. In this
Egan, Martin +2 more
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Centromere Protein F in Tumor Biology: Cancer's Achilles Heel
Cancer Medicine, Volume 14, Issue 10, May 2025.ABSTRACT Background Centromere protein F (CENP‐F) is an important nuclear matrix protein that regulates mitosis and the cell cycle, and plays a crucial role in recruiting spindle checkpoint proteins to maintain the accuracy of chromosome segregation.
Zitong Wan +11 more
wiley +1 more source
BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms
Traffic, Volume 26, Issue 4-6, April‐June 2025.Kinesin‐1 is auto‐inhibited and binds microtubules weakly. Binding of kinesin‐1 to the adaptor protein BicD enhances processive motion, while the microtubule‐associated protein MAP7 recruits more kinesin to the microtubule and enhances run length.
M. Yusuf Ali +4 more
wiley +1 more source
At the nucleus of cancer: how the nuclear envelope controls tumor progression
MedComm, Volume 6, Issue 2, February 2025.The review is focused on exploring novel intriguing perspectives on the role of the nuclear envelope in tumor progression. Alterations of nuclear envelope proteins result in the dysregulation of cellular pathways and promote tumorigenesis, highlighting that complex regulatory mechanisms lie behind the alterations in nuclear shape in cancer, thus ...
Francesca Paganelli +6 more
wiley +1 more source
Cell Reports, 2017 Miller-Dieker syndrome (MDS) is caused by a heterozygous deletion of chromosome 17p13.3 involving the genes LIS1 and YWHAE (coding for 14.3.3ε) and leads to malformations during cortical development.
Vira Iefremova +10 more
doaj +1 more source
Lis1 finds new digs on the desmosome [PDF]
Journal of Cell Biology, 2011 ![Figure][1] The centrosomal protein Lis1 (green) localizes to the cortex of differentiated epithelial cells. A protein that stabilizes microtubules also helps maintain desmosomes, [Sumigray et al.][2] report.
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American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
Toru Nagata +6 more
wiley +1 more source
Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
Nature Communications, 2016 Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on ...
Babu J. N. Reddy +7 more
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