Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection [PDF]
, 2016 Indexación: Web of Science.During the early steps of infection, retroviruses must direct the movement of the viral genome into the nucleus to complete their replication cycle.
Arriagada, Gloria +4 more
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Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1 [PDF]
Biochemical Journal, 2005 For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding proteins are proposed to be involved in the migration of neurons. Therefore we have specifically analysed how two members of the MAP family, MAP1B and LIS1
Jiménez Mateos, Eva +4 more
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Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]
, 2017 A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro +4 more
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New insights into the mechanism of dynein motor regulation by lissencephaly-1
eLife, 2020 Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
Steven M Markus +2 more
doaj +1 more source
LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. [PDF]
PLoS ONE, 2011 Microtubule organization and lysosomal secretion are both critical for the activation and function of osteoclasts, highly specialized polykaryons that are responsible for bone resorption and skeletal homeostasis.
Shiqiao Ye +9 more
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DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]
, 2019 T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
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EMBO Molecular Medicine, 2013 LIS1 (PAFAH1B1) mutation can impair neuronal migration, causing lissencephaly in humans. LIS1 loss is associated with dynein protein motor dysfunction, and disrupts the actin cytoskeleton through disregulated RhoGTPases.
Anamaria Sudarov +4 more
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Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]
, 2006 Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko +5 more
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Regulation of Cytoplasmic Dynein ATPase by Lis1 [PDF]
The Journal of Neuroscience, 2006 Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate ...
Mesngon, Mariano T. +8 more
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Lis1 regulates dynein by sterically blocking its mechanochemical cycle
eLife, 2014 Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development.
Katerina Toropova +6 more
doaj +1 more source