Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1 [PDF]
Biochemical Journal, 2005 For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding proteins are proposed to be involved in the migration of neurons. Therefore we have specifically analysed how two members of the MAP family, MAP1B and LIS1
Jiménez Mateos, Eva +4 more
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Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization [PDF]
Proceedings of the National Academy of Sciences, 2001 Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly ( LIS1 ), we deleted the first coding exon from the mouse Lis1 gene.
Cahana, A. +11 more
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NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 [PDF]
Proceedings of the National Academy of Sciences, 2010 The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC,
Yuehong, Yang +5 more
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Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1
Scientific Reports, 2022 Regulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human diseases.
Stanislav Kholmanskikh +2 more
doaj +1 more source
LIS1-leger og medisinsk usikkerhet – en kvalitativ studie [PDF]
, 2023 BAKGRUNN - Hvordan norske leger håndterer medisinsk usikkerhet, er lite studert. Formålet med studien var å undersøke hvordan leger i spesialisering del 1 (LIS1-leger) opplever og håndterer usikkerhet i en klinisk hverdag.
Gulbrandsen, Pål +5 more
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Regulation of Cytoplasmic Dynein ATPase by Lis1 [PDF]
The Journal of Neuroscience, 2006 Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate ...
Mesngon, Mariano T. +8 more
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Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. [PDF]
PLoS Biology, 2011 Radial glial cells (RGCs) are distinctive neural stem cells with an extraordinary slender bipolar morphology and dual functions as precursors and migration scaffolds for cortical neurons.
Ashley S Pawlisz, Yuanyi Feng
doaj +1 more source
eLife, 2022 The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets.
Jérémy Argenty +7 more
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LIS1 and Spindle Orientation in Neuroepithelial Cells [PDF]
Cell Stem Cell, 2008 Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
SCHWAMBORN, Jens Christian +1 more
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LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. [PDF]
PLoS ONE, 2011 Microtubule organization and lysosomal secretion are both critical for the activation and function of osteoclasts, highly specialized polykaryons that are responsible for bone resorption and skeletal homeostasis.
Shiqiao Ye +9 more
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