Results 31 to 40 of about 3,545 (191)
LIS1 Clamps Dynein to the Microtubule [PDF]
Cell, 2012 Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic
Trokter, Martina, Surrey, Thomas
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Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1 [PDF]
Biochemical Journal, 2005 For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding proteins are proposed to be involved in the migration of neurons. Therefore we have specifically analysed how two members of the MAP family, MAP1B and LIS1
Jiménez Mateos, Eva +4 more
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Frontiers in Cell and Developmental Biology, 2021 LIS1 is one of the principal genes related to Type I lissencephaly, a severe human brain malformation characterized by an abnormal neuronal migration in the cortex during embryonic development.
Raquel Garcia-Lopez +5 more
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Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization [PDF]
Proceedings of the National Academy of Sciences, 2001 Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly ( LIS1 ), we deleted the first coding exon from the mouse Lis1 gene.
Cahana, A. +11 more
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NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 [PDF]
Proceedings of the National Academy of Sciences, 2010 The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC,
Yuehong, Yang +5 more
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Lis1 activates dynein motility by modulating its pairing with dynactin [PDF]
, 2020 Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an inhibitor or an activator of mammalian dynein motility.
Sara Volz +11 more
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Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1
Scientific Reports, 2022 Regulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human diseases.
Stanislav Kholmanskikh +2 more
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Mechanisms of regulation of cytoplasmic dynein by Lis1 [PDF]
, 2021 Cytoplasmic dynein-1 (dynein) is a molecular motor that drives nearly all minus-end-directed microtubule-based transport in human cells, performing functions ranging from retrograde axonal transport to mitotic spindle assembly.
Gillies, John Patrick
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Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. [PDF]
PLoS Biology, 2011 Radial glial cells (RGCs) are distinctive neural stem cells with an extraordinary slender bipolar morphology and dual functions as precursors and migration scaffolds for cortical neurons.
Ashley S Pawlisz, Yuanyi Feng
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eLife, 2022 The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets.
Jérémy Argenty +7 more
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