Results 31 to 40 of about 2,714 (147)
Regulation of Cytoplasmic Dynein ATPase by Lis1 [PDF]
The Journal of Neuroscience, 2006 Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate ...
Mesngon, Mariano T. +8 more
openaire +3 more sources
eLife, 2022 The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets.
Jérémy Argenty +7 more
doaj +1 more source
LIS1 and Spindle Orientation in Neuroepithelial Cells [PDF]
Cell Stem Cell, 2008 Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
SCHWAMBORN, Jens Christian +1 more
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An Essential Postdevelopmental Role for Lis1 in Mice [PDF]
eneuro, 2018 LIS1 mutations cause lissencephaly (LIS), a severe developmental brain malformation. Much less is known about its role in the mature nervous system. LIS1 regulates the microtubule motor cytoplasmic dynein 1 (dynein), and as LIS1 and dynein are both expressed in the adult nervous system, Lis1 could potentially ...
Timothy J. Hines +6 more
openaire +2 more sources
New insights into the mechanism of dynein motor regulation by lissencephaly-1
eLife, 2020 Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
Steven M Markus +2 more
doaj +1 more source
LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. [PDF]
PLoS ONE, 2011 Microtubule organization and lysosomal secretion are both critical for the activation and function of osteoclasts, highly specialized polykaryons that are responsible for bone resorption and skeletal homeostasis.
Shiqiao Ye +9 more
doaj +1 more source
EMBO Molecular Medicine, 2013 LIS1 (PAFAH1B1) mutation can impair neuronal migration, causing lissencephaly in humans. LIS1 loss is associated with dynein protein motor dysfunction, and disrupts the actin cytoskeleton through disregulated RhoGTPases.
Anamaria Sudarov +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 LIS1 (PAFAH1B1) plays a major role in the developing cerebral cortex, and haploinsufficient mutations cause human lissencephaly type 1. We have studied morphological and functional properties of the cerebral cortex of mutant mice harboring a deletion in ...
E. Domínguez-Sala +10 more
doaj +1 more source
Lis1 regulates dynein by sterically blocking its mechanochemical cycle
eLife, 2014 Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development.
Katerina Toropova +6 more
doaj +1 more source
eLife, 2020 Heterozygous loss of human PAFAH1B1 (coding for LIS1) results in the disruption of neurogenesis and neuronal migration via dysregulation of microtubule (MT) stability and dynein motor function/localization that alters mitotic spindle orientation ...
Hyang Mi Moon +3 more
doaj +1 more source