Results 11 to 20 of about 3,592 (196)

HIV-1 Tat interacts with LIS1 protein [PDF]

Retrovirology, 2005
Background HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII).
Turner Willie, Lane William S, Voloshin Yaroslav, Sapir Tamar, Ammosova Tatyana, Epie Nicolas, Reiner Orly, Nekhai Sergei   +7 more
doaj   +6 more sources

Two microtubule-plus-end binding proteins LIS1-1 and LIS1-2, homologues of human LIS1 in Neurospora crassa [PDF]

Fungal Genetics and Biology, 2015
LIS1 is a microtubule (Mt) plus-end binding protein that interacts with the dynein/dynactin complex. In humans, LIS1 is required for proper nuclear and organelle migration during cell growth. Although gene duplication is absent from Neurospora crassa, we found two paralogues of human LIS1.
Callejas-Negrete, Olga A, Plamann, Michael, Schnittker, Robert, Bartnicki-García, Salomon, Roberson, Robert W, Pimienta, Genaro, Mouriño-Pérez, Rosa R   +6 more
openaire   +6 more sources

LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex [PDF]

Human Molecular Genetics, 2013
Heterozygous LIS1 mutations are responsible for the human neuronal migration disorder lissencephaly. Mitotic functions of LIS1 have been suggested from many organisms throughout evolution. However, the cellular functions of LIS1 at distinct intracellular compartments such as the centrosome and the cell cortex have not been well defined especially ...
Moon, Hyang Mi, Youn, Yong Ha, Pemble, Hayley, Yingling, Jessica, Wittmann, Torsten, Wynshaw-Boris, Anthony   +5 more
openaire   +6 more sources

Nde1 promotes Lis1-mediated activation of dynein

Nature Communications, 2023
Cytoplasmic dynein drives the motility and force generation functions towards the microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an active transport complex is facilitated by Lis1 and Nde1/Ndel1.
Yuanchang Zhao, Sena Oten, Ahmet Yildiz
doaj   +4 more sources

LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons [PDF]

Frontiers in Molecular Neuroscience, 2022
Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey, Liang Shi, Remi A. Brebion, Deanna S. Smith   +3 more
doaj   +2 more sources

Inhibition of PP2A by LIS1 increases HIV-1 gene expression [PDF]

Retrovirology, 2006
Background Lissencephaly is a severe brain malformation in part caused by mutations in the LIS1 gene. LIS1 interacts with microtubule-associated proteins, and enhances transport of microtubule fragments.
Turner Willie, Ammosova Tatyana, Epie Nicolas, Nekhai Sergei   +3 more
doaj   +3 more sources

Structural basis for cytoplasmic dynein-1 regulation by Lis1 [PDF]

eLife, 2022
The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor ...
John P Gillies, Janice M Reimer, Eva P Karasmanis, Indrajit Lahiri, Zaw Min Htet, Andres E Leschziner, Samara L Reck-Peterson   +6 more
doaj   +3 more sources

Lis1 regulates dynein by sterically blocking its mechanochemical cycle [PDF]

eLife, 2014
Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development.
Katerina Toropova, Sirui Zou, Anthony J Roberts, William B Redwine, Brian S Goodman, Samara L Reck-Peterson, Andres E Leschziner   +6 more
doaj   +2 more sources

Identification of novel Lis1 protein interaction partners: Investigations towards cellular Lis1 functions [PDF]

, 2010
Die Haploinsuffizienz des Lis1 führt beim Menschen zu der Lissenzephalie Typ 1. Mausmutanten mit homozygotem Lis1 sind vorgeburtlich letal, und männliche Mäuse mit einer Genfalle im Lis1 Lokus sind infertil und zeigen eine deutlich verringerte Spermienzahl. Diese Mutationen verdeutlichen die tragende Bedeutung von Lis1 in unterschiedlichen Zellen. Mit
Jung, Bomi
openaire   +3 more sources

Lis1 is an initiation factor for dynein-driven organelle transport [PDF]

Journal of Cell Biology, 2012
The molecular motor cytoplasmic dynein is responsible for most minus-end–directed, microtubule-based transport in eukaryotic cells. It is especially important in neurons, where defects in microtubule-based motility have been linked to neurological diseases. For example, lissencephaly is caused by mutations in the dynein-associated protein Lis1. In this
Egan, Martin, Tan, Kaeling, Reck-Peterson, Samara L   +2 more
openaire   +6 more sources