Results 11 to 20 of about 3,545 (191)
HIV-1 Tat interacts with LIS1 protein [PDF]
Retrovirology, 2005 Background HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII).
Turner Willie +7 more
doaj +7 more sources
Molecular Psychiatry, 2002 LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the
Reiner, Orly +3 more
openaire +4 more sources
Inhibition of PP2A by LIS1 increases HIV-1 gene expression [PDF]
Retrovirology, 2006 Background Lissencephaly is a severe brain malformation in part caused by mutations in the LIS1 gene. LIS1 interacts with microtubule-associated proteins, and enhances transport of microtubule fragments.
Turner Willie +3 more
doaj +4 more sources
LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex [PDF]
Human Molecular Genetics, 2013 Heterozygous LIS1 mutations are responsible for the human neuronal migration disorder lissencephaly. Mitotic functions of LIS1 have been suggested from many organisms throughout evolution. However, the cellular functions of LIS1 at distinct intracellular compartments such as the centrosome and the cell cortex have not been well defined especially ...
Moon, Hyang Mi +5 more
openaire +6 more sources
Regulation of Cytoplasmic Dynein ATPase by Lis1 [PDF]
The Journal of Neuroscience, 2006 Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate ...
Mesngon, Mariano T. +8 more
openaire +5 more sources
Nde1 promotes Lis1-mediated activation of dynein
Nature Communications, 2023 Cytoplasmic dynein drives the motility and force generation functions towards the microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an active transport complex is facilitated by Lis1 and Nde1/Ndel1.
Yuanchang Zhao, Sena Oten, Ahmet Yildiz
doaj +4 more sources
Structural basis for cytoplasmic dynein-1 regulation by Lis1 [PDF]
eLife, 2022 The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor ...
John P Gillies +6 more
doaj +3 more sources
Identification of novel Lis1 protein interaction partners: Investigations towards cellular Lis1 functions [PDF]
, 2010 Die Haploinsuffizienz des Lis1 führt beim Menschen zu der Lissenzephalie Typ 1. Mausmutanten mit homozygotem Lis1 sind vorgeburtlich letal, und männliche Mäuse mit einer Genfalle im Lis1 Lokus sind infertil und zeigen eine deutlich verringerte Spermienzahl. Diese Mutationen verdeutlichen die tragende Bedeutung von Lis1 in unterschiedlichen Zellen. Mit
Jung, Bomi
openaire +3 more sources
Lis1 regulates dynein by sterically blocking its mechanochemical cycle [PDF]
eLife, 2014 Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development.
Katerina Toropova +6 more
doaj +2 more sources
An Essential Postdevelopmental Role for Lis1 in Mice [PDF]
eneuro, 2018 LIS1 mutations cause lissencephaly (LIS), a severe developmental brain malformation. Much less is known about its role in the mature nervous system. LIS1 regulates the microtubule motor cytoplasmic dynein 1 (dynein), and as LIS1 and dynein are both expressed in the adult nervous system, Lis1 could potentially ...
Timothy J. Hines +6 more
openaire +3 more sources