Results 11 to 20 of about 2,714 (147)

Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids [PDF]

Nature Communications
LIS1-lissencephaly is a neurodevelopmental disorder marked by reduced cortical folding and severe neurological impairment. Although all cases result from heterozygous mutations in the LIS1 gene, patients present a broad spectrum of severity. Here, we use
Lea Zillich, Matteo Gasparotto, Andrea Carlo Rossetti, Olivia Fechtner, Camille Maillard, Anne Hoffrichter, Eric Zillich, Ammar Jabali, Fabio Marsoner, Annasara Artioli, Ruven Wilkens, Christina B. Schroeter, Andreas Hentschel, Stephanie H. Witt, Nico Melzer, Sven G. Meuth, Tobias Ruck, Philipp Koch, Andreas Roos, Nadia Bahi-Buisson, Fiona Francis, Julia Ladewig   +21 more
doaj   +2 more sources

A LisH-domain protein interaction map reveals a Lis1-ARIH2-dynein regulatory axis [PDF]

iScience
Summary: LisH-domain-containing proteins are involved in diverse cellular processes and disease mechanisms, yet their functional interaction landscape remains poorly characterized.
Devanshi Gupta, Subbareddy Maddika
doaj   +2 more sources

Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1 [PDF]

Frontiers in Molecular Biosciences
Cytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing crucial roles in intracellular organisation and cell division.
Amit Kumawat
doaj   +2 more sources

MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1 [PDF]

Cancer Cell International
Background The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma. Methods The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target gene of ...
Zhicheng Wei, Bowen Xu, Yanjiang Yin, Jianping Chang, Zhiyu Li, Yefan Zhang, Xu Che, Xinyu Bi   +7 more
doaj   +2 more sources

Selective Lis1 inactivation disrupts migration and positioning of cortical somatostatin interneurons [PDF]

Scientific Reports
One subtype of interneurons, classified by their neurochemical properties, are somatostatin-positive (SST+) interneurons, which express somatostatin along with GABA and form synapses with both pyramidal neurons and other interneurons.
A. Pombero, R. García-López, E. Geijo-Barrientos, S. Martínez   +3 more
doaj   +2 more sources

Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease [PDF]

Nature Communications
The viscoelastic properties of tissues influence their morphology and cellular behavior, yet little is known about changes in these properties during brain malformations.
Maayan Karlinski Zur, Bidisha Bhattacharya, Inna Solomonov, Sivan Ben Dror, Alon Savidor, Yishai Levin, Amir Prior, Tamar Sapir, Talia Harris, Tsviya Olender, Rita Schmidt, J. M. Schwarz, Irit Sagi, Amnon Buxboim, Orly Reiner   +14 more
doaj   +2 more sources

Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome

Frontiers in Cellular Neuroscience, 2019
LIS1 is the main causative gene for lissencephaly, while MeCP2 is the main causative gene for Rett syndrome, both of which are neurodevelopmental diseases.
Gabi Gerlitz, Aditya Kshirsagar, Tsviya Olender   +2 more
exaly   +3 more sources

LncRNA RASAL2-AS1 promotes METTL14-mediated m6A methylation in the proliferation and progression of head and neck squamous cell carcinoma [PDF]

Cancer Cell International
Background Long non-coding RNAs (lncRNAs) are key regulators of the 6-methyladenosine (m6A) epigenetic modification, playing a role in the initiation and progression of tumors.
Meiting Rong, Ming Zhang, Feihong Dong, Ke Wu, Bingkun Cai, Jinrui Niu, Le Yang, Zhongyan Li, Hui-yi Lu   +8 more
doaj   +2 more sources

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

Nature Communications, 2023
Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and it governs ...
Aditya Kshirsagar, Svetlana Maslov Doroshev, Anna Gorelik, Tsviya Olender, Tamar Sapir, Daisuke Tsuboi, Irit Rosenhek-Goldian, Sergey Malitsky, Maxim Itkin, Amir Argoetti, Yael Mandel-Gutfreund, Sidney R. Cohen, Jacob H. Hanna, Igor Ulitsky, Kozo Kaibuchi, Orly Reiner   +15 more
doaj   +1 more source

LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons

Frontiers in Molecular Neuroscience, 2022
Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey, Liang Shi, Remi A. Brebion, Deanna S. Smith   +3 more
doaj   +1 more source