Results 21 to 30 of about 2,714 (147)
Molecular Psychiatry, 2002 LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the
Reiner, Orly +3 more
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Structures of human dynein in complex with the lissencephaly 1 protein, LIS1
eLife, 2023 The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form.
Janice M Reimer +3 more
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LIS1 Clamps Dynein to the Microtubule [PDF]
Cell, 2012 Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic
Trokter, Martina, Surrey, Thomas
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NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 [PDF]
Proceedings of the National Academy of Sciences, 2010 The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2 (NudC-like ...
Yuehong, Yang +5 more
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Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1 [PDF]
Biochemical Journal, 2005 For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding proteins are proposed to be involved in the migration of neurons. Therefore we have specifically analysed how two members of the MAP family, MAP1B and LIS1
Jiménez Mateos, Eva +4 more
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Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1
Scientific Reports, 2022 Regulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human diseases.
Stanislav Kholmanskikh +2 more
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Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization [PDF]
Proceedings of the National Academy of Sciences, 2001 Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly ( LIS1 ), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique ...
Cahana, A. +11 more
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LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex [PDF]
Human Molecular Genetics, 2013 Heterozygous LIS1 mutations are responsible for the human neuronal migration disorder lissencephaly. Mitotic functions of LIS1 have been suggested from many organisms throughout evolution. However, the cellular functions of LIS1 at distinct intracellular compartments such as the centrosome and the cell cortex have not been well defined especially ...
Moon, Hyang Mi +5 more
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Inhibition of PP2A by LIS1 increases HIV-1 gene expression
Retrovirology, 2006 Background Lissencephaly is a severe brain malformation in part caused by mutations in the LIS1 gene. LIS1 interacts with microtubule-associated proteins, and enhances transport of microtubule fragments.
Turner Willie +3 more
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Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. [PDF]
PLoS Biology, 2011 Radial glial cells (RGCs) are distinctive neural stem cells with an extraordinary slender bipolar morphology and dual functions as precursors and migration scaffolds for cortical neurons.
Ashley S Pawlisz, Yuanyi Feng
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