Results 21 to 30 of about 3,545 (191)

Lis1 is an initiation factor for dynein-driven organelle transport [PDF]

Journal of Cell Biology, 2012
The molecular motor cytoplasmic dynein is responsible for most minus-end–directed, microtubule-based transport in eukaryotic cells. It is especially important in neurons, where defects in microtubule-based motility have been linked to neurological diseases. For example, lissencephaly is caused by mutations in the dynein-associated protein Lis1. In this
Egan, Martin, Tan, Kaeling, Reck-Peterson, Samara L   +2 more
openaire   +6 more sources

A LisH-domain protein interaction map reveals a Lis1-ARIH2-dynein regulatory axis [PDF]

iScience
Summary: LisH-domain-containing proteins are involved in diverse cellular processes and disease mechanisms, yet their functional interaction landscape remains poorly characterized.
Devanshi Gupta, Subbareddy Maddika
doaj   +2 more sources

Selective Lis1 inactivation disrupts migration and positioning of cortical somatostatin interneurons [PDF]

Scientific Reports
One subtype of interneurons, classified by their neurochemical properties, are somatostatin-positive (SST+) interneurons, which express somatostatin along with GABA and form synapses with both pyramidal neurons and other interneurons.
A. Pombero, R. García-López, E. Geijo-Barrientos, S. Martínez   +3 more
doaj   +2 more sources

MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1 [PDF]

Cancer Cell International
Background The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma. Methods The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target gene of ...
Zhicheng Wei, Bowen Xu, Yanjiang Yin, Jianping Chang, Zhiyu Li, Yefan Zhang, Xu Che, Xinyu Bi   +7 more
doaj   +2 more sources

Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease [PDF]

Nature Communications
The viscoelastic properties of tissues influence their morphology and cellular behavior, yet little is known about changes in these properties during brain malformations.
Maayan Karlinski Zur, Bidisha Bhattacharya, Inna Solomonov, Sivan Ben Dror, Alon Savidor, Yishai Levin, Amir Prior, Tamar Sapir, Talia Harris, Tsviya Olender, Rita Schmidt, J. M. Schwarz, Irit Sagi, Amnon Buxboim, Orly Reiner   +14 more
doaj   +2 more sources

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography

Brain Sciences, 2023
Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors.
Alpen Ortuğ, Tadashi Shiohama, Emi Takahashi   +2 more
exaly   +3 more sources

LncRNA RASAL2-AS1 promotes METTL14-mediated m6A methylation in the proliferation and progression of head and neck squamous cell carcinoma [PDF]

Cancer Cell International
Background Long non-coding RNAs (lncRNAs) are key regulators of the 6-methyladenosine (m6A) epigenetic modification, playing a role in the initiation and progression of tumors.
Meiting Rong, Ming Zhang, Feihong Dong, Ke Wu, Bingkun Cai, Jinrui Niu, Le Yang, Zhongyan Li, Hui-yi Lu   +8 more
doaj   +2 more sources

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

Nature Communications, 2023
Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and it governs ...
Aditya Kshirsagar, Svetlana Maslov Doroshev, Anna Gorelik, Tsviya Olender, Tamar Sapir, Daisuke Tsuboi, Irit Rosenhek-Goldian, Sergey Malitsky, Maxim Itkin, Amir Argoetti, Yael Mandel-Gutfreund, Sidney R. Cohen, Jacob H. Hanna, Igor Ulitsky, Kozo Kaibuchi, Orly Reiner   +15 more
doaj   +1 more source

LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons

Frontiers in Molecular Neuroscience, 2022
Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey, Liang Shi, Remi A. Brebion, Deanna S. Smith   +3 more
doaj   +1 more source

Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

eLife, 2023
The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form.
Janice M Reimer, Morgan E DeSantis, Samara L Reck-Peterson, Andres E Leschziner   +3 more
doaj   +1 more source