Results 21 to 30 of about 3,592 (196)

Interneuron Heterotopia in the Lis1 Mutant Mouse Cortex Underlies a Structural and Functional Schizophrenia-Like Phenotype [PDF]

Frontiers in Cell and Developmental Biology, 2021
LIS1 is one of the principal genes related to Type I lissencephaly, a severe human brain malformation characterized by an abnormal neuronal migration in the cortex during embryonic development.
Raquel Garcia-Lopez, Ana Pombero, Alicia Estirado, Emilio Geijo-Barrientos, Salvador Martinez, Salvador Martinez   +5 more
doaj   +2 more sources

Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease [PDF]

Nature Communications
The viscoelastic properties of tissues influence their morphology and cellular behavior, yet little is known about changes in these properties during brain malformations.
Maayan Karlinski Zur, Bidisha Bhattacharya, Inna Solomonov, Sivan Ben Dror, Alon Savidor, Yishai Levin, Amir Prior, Tamar Sapir, Talia Harris, Tsviya Olender, Rita Schmidt, J. M. Schwarz, Irit Sagi, Amnon Buxboim, Orly Reiner   +14 more
doaj   +2 more sources

MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1 [PDF]

Cancer Cell International
Background The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma. Methods The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target gene of ...
Zhicheng Wei, Bowen Xu, Yanjiang Yin, Jianping Chang, Zhiyu Li, Yefan Zhang, Xu Che, Xinyu Bi   +7 more
doaj   +2 more sources

The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review. [PDF]

Hippocampus
ABSTRACT Hippocampal abnormalities are frequently associated with neurodevelopmental disorders as interneurons are crucial in establishing the network connectivity of neurons. This systematic review analyzed primary literature with a focus on aberrant hippocampal interneuron migration as an etiology for neurodevelopmental disorders, summarizing the ...
Till MAC, Reid HMO, Murphy I, Christie BR.   +3 more
europepmc   +2 more sources

Cancer Stem Cells Shift Metabolite Acetyl-Coenzyme A to Abrogate the Differentiation of CD103⁺ T Cells. [PDF]

Adv Sci (Weinh)
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Lei J, Ji H, Guo J, Liu M, Su D, Zheng Y, Xu L, Cao Q, Ren T, Gui J, Wen Z.   +10 more
europepmc   +2 more sources

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

Nature Communications, 2023
Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and it governs ...
Aditya Kshirsagar, Svetlana Maslov Doroshev, Anna Gorelik, Tsviya Olender, Tamar Sapir, Daisuke Tsuboi, Irit Rosenhek-Goldian, Sergey Malitsky, Maxim Itkin, Amir Argoetti, Yael Mandel-Gutfreund, Sidney R. Cohen, Jacob H. Hanna, Igor Ulitsky, Kozo Kaibuchi, Orly Reiner   +15 more
doaj   +1 more source

LIS1—no more no less [PDF]

Molecular Psychiatry, 2002
LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the
Reiner, Orly, Cahana, Aviv, Escámez, Teresa, Martínez, Salvador   +3 more
openaire   +3 more sources

Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

eLife, 2023
The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form.
Janice M Reimer, Morgan E DeSantis, Samara L Reck-Peterson, Andres E Leschziner   +3 more
doaj   +1 more source

Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor. [PDF]

Cytoskeleton (Hoboken)
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
King SM.
europepmc   +2 more sources

LIS1 Clamps Dynein to the Microtubule [PDF]

Cell, 2012
Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic
Trokter, Martina, Surrey, Thomas
openaire   +2 more sources