Results 161 to 170 of about 48,169 (274)
bioRxiv, 2018 Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
H. Yamaguchi +3 more
semanticscholar +1 more source
Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.ABSTRACT Background Late‐onset Tay–Sachs disease (LOTS) is a rare lysosomal disorder that contrasts with the classical infantile form by presenting with milder and heterogeneous neurological manifestations, including lower motor neuron phenotypes.
Rodrigo Siqueira Soares Frezatti +11 more
wiley +1 more source
eLife, 2015 In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axon ...
Urko del Castillo +3 more
doaj +1 more source
Cytoplasmic dynein transports axonal microtubules in a polarity-sorting manner
Cell Reports, 2017 Summary Axonal microtubules are predominantly organized into a plus-end-out pattern.Here, we examined the polarity-sorting mechanism underlying this organization both experimentally and using modeling.
Anand N. Rao +6 more
semanticscholar +1 more source
The Secret (Mitotic) Life of Clathrin
Traffic, Volume 27, Issue 3, September 2026.A perspective on the function of clathrin at the mitotic spindle during cell division. ABSTRACT The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During
Stephen J. Royle
wiley +1 more source
Mechanisms of Regulation of Cytoplasmic Dynein [PDF]
, 2019 Cytoplasmic dynein-1 (dynein) is a microtubule-based motor protein that is essential for maintaining proper spatial and temporal organization of the cellular interior during both interphase and cell division.
Htet, Zaw Min
core
Gsk-3Β Phosphorylation Of Cytoplasmic Dynein Reduces Ndel1 Binding To Intermediate Chains And Alters Dynein Motility [PDF]
, 2015 Glycogen synthase kinase 3 (GSK-3) has been linked to regulation of kinesin-dependent axonal transport in squid and flies, and to indirect regulation of cytoplasmic dynein. We have now found evidence for direct regulation of dynein by mammalian GSK-3β in
Alexander, Michael +4 more
core +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 5120-5147, August 2026.This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon +27 more
wiley +1 more source
The Mechanical Components of the Dynein Motor
The Scientific World Journal, 2010 Unlike our understanding of the other two classes of cytoskeletal motor proteins, the myosins and kinesins, we have only recently begun to comprehend the molecular mechanism for how dynein produces force and movement.
Peter Höök
doaj +1 more source