Results 111 to 120 of about 48,169 (274)

Molecular mechanism of cytoplasmic dynein tension sensing

Nature Communications, 2019
Cytoplasmic dynein is the most complex cytoskeletal motor protein and is responsible for numerous biological functions. Essential to dynein’s function is its capacity to respond anisotropically to tension, so that its microtubule-binding domains bind ...
Lu Rao, Florian Berger, M. Nicholas, A. Gennerich   +3 more
semanticscholar   +1 more source

Polyphenol dietary supplementation prevents inflammation‐induced muscle atrophy in a zebrafish (Danio rerio) model

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Diet‐induced inflammation is a major cause of muscle degeneration impacting human and animal health. Owing to their anti‐inflammatory and antioxidant properties, polyphenols have attracted considerable interest as feed additives.
Graziella Orso, Monica Matuozzo, Mariapina Rocco, Seyed Hossein Hoseinifar, Ghasem Ashouri, Andrea Scaloni, Marina Paolucci, Chiara D'Ambrosio, Roberta Imperatore   +8 more
wiley   +1 more source

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

Journal of Cell Biology, 2017
The molecular motor dynein concentrates at the kinetochore region of mitotic chromosomes in animals to accelerate spindle microtubule capture and to control spindle checkpoint signaling.
José B. Gama, C. Pereira, Patrícia A. Simões, R. Celestino, R. Reis, D. J. Barbosa, Helena R Pires, Cátia Carvalho, João Amorim, A. Carvalho, Dhanya K. Cheerambathur, R. Gassmann   +11 more
semanticscholar   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3

Nature Communications, 2017
By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid.
C. Olcese, Mitali P. Patel, A. Shoemark, S. Kiviluoto, M. Legendre, H. Williams, C. Vaughan, Jane D. Hayward, A. Goldenberg, Richard D Emes, M. Munye, Laura Dyer, Thomas Cahill, J. Bevillard, C. Gehrig, M. Guipponi, S. Chantot, P. Duquesnoy, Lucie Thomas, L. Jeanson, B. Copin, A. Tamalet, C. Thauvin-Robinet, J. Papon, A. Garin, I. Pin, Gabriella Vera, P. Aurora, Mahmoud R. Fassad, L. Jenkins, Christopher Boustred, T. Cullup, M. Dixon, A. Onoufriadis, A. Bush, E. Chung, S. Antonarakis, M. Loebinger, R. Wilson, M. Armengot, E. Escudier, C. Hogg, S. Amselem, Zhaoxia Sun, L. Bartoloni, J. Blouin, H. Mitchison, S. Al-Turki, C. Anderson, Dinu Antony, I. Barroso, P. Beales, J. Bentham, S. Bhattacharya, K. Carss, K. Chatterjee, S. Çırak, C. Cosgrove, D. Allan, R. Durbin, David Fitzpatrick, J. Floyd, A. Foley, C. Franklin, M. Futema, S. Humphries, M. Hurles, Shane A. McCarthy, Dawn Muddyman, F. Muntoni, V. Parker, F. Payne, V. Plagnol, L. Raymond, D. Savage, P. Scambler, M. Schmidts, R. Semple, E. Serra, J. Stalker, M. van Kogelenberg, Parthiban Vijayarangakannan, Klaudia Walter   +82 more
semanticscholar   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Force-Induced Bidirectional Stepping [PDF]

, 2014
Cytoplasmic dynein is a minus-end-directed microtubule motor whose mechanism of movement remains poorly understood. Here, we use optical tweezers to examine the force-dependent stepping behavior of yeast cytoplasmic dynein.
Of Cytoplasmic Dynein, Ronald D. Vale
core  

Neuronal migration defects in the Loa dynein mutant mouse

Neural Development, 2011
Background Cytoplasmic dynein and its regulatory proteins have been implicated in neuronal and non-neuronal cell migration. A genetic model for analyzing the role of cytoplasmic dynein specifically in these processes has, however, been lacking.
Ori-McKenney Kassandra M, Vallee Richard B   +1 more
doaj   +1 more source

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

Cilia-mediated signalling in the embryonic nodes: A computational fluid-structure-protein interaction (FSPI) model [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Norris, D, Chen, D, Ventikos, Y   +3 more
core