Results 91 to 100 of about 60,261 (241)

NuMA recruits dynein activity to microtubule minus-ends at mitosis

eLife, 2017
To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into
Christina L Hueschen, Samuel J Kenny, Ke Xu, Sophie Dumont   +3 more
doaj   +1 more source

The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]

, 2015
Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista, A Onnis, AC Smith, AH Hutagalung, AL Kullas, AW van der Velden, BT Keady, C Cassioli, C Geisler, C Margadant, C T Baldari, C Wasmeier, CJ Westlake, CP Horgan, DA MacLeod, DS Gomez, E Schonteich, EM Manders, F Finetti, F Finetti, F Finetti, G Bonello, G Iezzi, G Patino-Lopez, GJ Pazour, H Soares, I Jordens, JA Follit, JC Stinchcombe, JK Chen, K Geddes, L Patrussi, L Patrussi, LB Pedersen, LI Ehrlich, M de la Roche, M Esquerré, M Gottardo, M Kurowska, MV Nachury, N Capitani, NB Martín-Cófreces, RS Kalupahana, S Pacini, S Spanò, S Spanò, S Spanò, S Wang, SR McGlashan, SY Wong, V Das, VM Wu   +51 more
core   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Inhibition and relaxation of sea urchin sperm flagella by vanadate [PDF]

, 1980
Direct measurements of the stiffness (elastic bending resistance) of demembranated sera urchin sperm flagella were made in the presence of MgATP2- and vanadate.
Okuno, Makoto
core   +3 more sources

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Application of temperature replica exchange molecular dynamics: Structure of mitotic spindle-associated protein SHE1 and its binding to dynein

Computational and Structural Biotechnology Journal
Cytoskeletal motor protein dynein belongs to the AAA+ superfamily of enzymes, functioning as a mechanochemical ATPase that converts chemical energy into force to drive its retrograde movements along microtubules.
Laleh Alisaraie, Oliver Stueker, Sayi’Mone Tati   +2 more
doaj   +1 more source

The XMAP215-family protein DdCP224 is required for cortical interactions of microtubules

BMC Cell Biology, 2004
Background Interactions of peripheral microtubule tips with the cell cortex are of crucial importance for nuclear migration, spindle orientation, centrosome positioning and directional cell movement.
Hestermann Andrea, Gräf Ralph
doaj   +1 more source

Model for the unidirectional motion of a dynein molecule

, 2008
Cytoplasmic dyneins transport cellular organelles by moving on a microtubule filament. It has been found recently that depending on the applied force and the concentration of the adenosine triphosphate (ATP) molecules, dynein's step size varies. Based on
B. Alberts, M. Schnitzer, S. M. King, Sutapa Mukherji, T. Shima   +4 more
core   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Flagellar Radial Spoke Protein 2 Is a Calmodulin Binding Protein Required for Motility in \u3cem\u3eChlamydomonas reinhardtii\u3c/em\u3e [PDF]

, 2004
Genetic and morphological studies have revealed that the radial spokes regulate ciliary and flagellar bending. Functional and biochemical analysis and the discovery of calmodulin in the radial spokes suggest that the regulatory mechanism involves control
Sale, Winfield S., Yang, Chun, Yang, Pinfen   +2 more
core   +1 more source