Results 51 to 60 of about 39,736 (248)

Bim1-dynein-mediated effective bias ensures timely MTOC clustering and nuclear migration.

, 2019
(A) Schematic of MTOC clustering, nuclear migration, biorientation of chromosomes and possible chromosomal attachments. Arrows within a cell indicate direction forces required for nuclear migration and MTOC clustering.
Subhendu Som (6336227), Dibyendu Bhattacharyya (184588), Raja Paul (594399), Shreyas Sridhar (6336230), Kaustuv Sanyal (169834), Neha Varshney (6336224), Saptarshi Chatterjee (1750480)   +6 more
core   +1 more source

Cryo-EM captures early intermediate steps in dynein activation by LIS1

Nature Communications
Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes.
Kendrick H. V. Nguyen, Eva P. Karasmanis, Agnieszka A. Kendrick, Samara L. Reck-Peterson, Andres E. Leschziner   +4 more
doaj   +1 more source

The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation

Scientific Reports, 2016
Cytoplasmic dynein 1 is a multi-protein intracellular motor essential for mediating several mitotic functions, including the establishment of proper spindle orientation.
Sagar Mahale, Megha Kumar, Amit Sharma, Aswini Babu, Shashi Ranjan, Chetana Sachidanandan, Sivaram V. S. Mylavarapu   +6 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Dynein at the nuclear envelope [PDF]

The EMBO Reports, 2010
Most cellular organelles are positioned through active transport by motor proteins. The authors discuss the evidence that dynein has important cell cycle-regulated functions in this context at the nuclear envelope.
Tanenbaum, M.E., Akhmanova, A.S., Medema, R.H.   +2 more
openaire   +4 more sources

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

, 2007
Aims: The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions.
A H Mustafa (16084112), E M C Fisher (13667173), R. Gulati, C S Baker (13551397), D. D. Ateh, C. D. Nickols, I K Hussain (16084109), D D Ateh (16074635), R Gulati (16084115), M M Bird (16074644), C. S. Baker, M. M. Bird, I. K. Hussain, J E Martin (13451187), K. M. Price, L. Greensmith, K M Price (16074638), J. E. Martin, L Greensmith (16074647), E. M. C. Fisher, C D Nickols (16074641), A. H. Mustafa, M. Hafezparast, Majid Hafezparast (4461484)   +23 more
core   +1 more source

Ciliobrevins as Tools for Studying Dynein Motor Function

Frontiers in Cellular Neuroscience, 2015
Dyneins are a small class of molecular motors that bind to microtubules and walk towards their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements.
Douglas eRoossien, Kyle eMiller, Gianluca eGallo   +2 more
doaj   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

The human cytoplasmic dynein interactome reveals novel activators of motility

eLife, 2017
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson   +8 more
doaj   +1 more source