Results 51 to 60 of about 37,129 (243)

The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation

Scientific Reports, 2016
Cytoplasmic dynein 1 is a multi-protein intracellular motor essential for mediating several mitotic functions, including the establishment of proper spindle orientation.
Sagar Mahale, Megha Kumar, Amit Sharma, Aswini Babu, Shashi Ranjan, Chetana Sachidanandan, Sivaram V. S. Mylavarapu   +6 more
doaj   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Bim1-dynein-mediated effective bias ensures timely MTOC clustering and nuclear migration.

, 2019
(A) Schematic of MTOC clustering, nuclear migration, biorientation of chromosomes and possible chromosomal attachments. Arrows within a cell indicate direction forces required for nuclear migration and MTOC clustering.
Subhendu Som (6336227), Dibyendu Bhattacharyya (184588), Raja Paul (594399), Shreyas Sridhar (6336230), Kaustuv Sanyal (169834), Neha Varshney (6336224), Saptarshi Chatterjee (1750480)   +6 more
core   +1 more source

Ciliobrevins as Tools for Studying Dynein Motor Function

Frontiers in Cellular Neuroscience, 2015
Dyneins are a small class of molecular motors that bind to microtubules and walk towards their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements.
Douglas eRoossien, Kyle eMiller, Gianluca eGallo   +2 more
doaj   +1 more source

A mathematical understanding of how cytoplasmic dynein walks on microtubules [PDF]

Royal Society Open Science, 2018
Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles, a mechanical model
L. Trott, M. Hafezparast, A. Madzvamuse   +2 more
doaj   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

, 2007
Aims: The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions.
A H Mustafa (16084112), E M C Fisher (13667173), R. Gulati, C S Baker (13551397), D. D. Ateh, C. D. Nickols, I K Hussain (16084109), D D Ateh (16074635), R Gulati (16084115), M M Bird (16074644), C. S. Baker, M. M. Bird, I. K. Hussain, J E Martin (13451187), K. M. Price, L. Greensmith, K M Price (16074638), J. E. Martin, L Greensmith (16074647), E. M. C. Fisher, C D Nickols (16074641), A. H. Mustafa, M. Hafezparast, Majid Hafezparast (4461484)   +23 more
core   +1 more source

Cryo-EM captures early intermediate steps in dynein activation by LIS1

Nature Communications
Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes.
Kendrick H. V. Nguyen, Eva P. Karasmanis, Agnieszka A. Kendrick, Samara L. Reck-Peterson, Andres E. Leschziner   +4 more
doaj   +1 more source

The human cytoplasmic dynein interactome reveals novel activators of motility

eLife, 2017
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson   +8 more
doaj   +1 more source

PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana

Cytoskeleton, EarlyView.
ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes, Norman R. Groves, Jessica Z. Li, Lily N. Thompson, Brian J. Smith, Aman Y. Husbands, Iris Meier   +6 more
wiley   +1 more source