Structural basis for cytoplasmic dynein-1 regulation by Lis1
eLife, 2022 The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor ...
John P Gillies +6 more
doaj +1 more source
Dynein activators and adaptors at a glance
Journal of Cell Science, 2019 Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that drives the movement of diverse cargos along the microtubule cytoskeleton, including organelles, vesicles and RNAs.
Mara A Olenick, E. Holzbaur
semanticscholar +1 more source
Dynein light intermediate chains as pivotal determinants of dynein multifunctionality [PDF]
Journal of Cell Science, 2021 ABSTRACT In animal cells, a single cytoplasmic dynein motor mediates microtubule minus-end-directed transport, counterbalancing dozens of plus-end-directed kinesins. The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which engage the ...
Amrita Kumari +3 more
openaire +4 more sources
Bim1-dynein-mediated effective bias ensures timely MTOC clustering and nuclear migration. [PDF]
, 2019 (A) Schematic of MTOC clustering, nuclear migration, biorientation of chromosomes and possible chromosomal attachments. Arrows within a cell indicate direction forces required for nuclear migration and MTOC clustering.
Subhendu Som (6336227) +6 more
core +1 more source
LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons
Frontiers in Molecular Neuroscience, 2022 Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey +3 more
doaj +1 more source
Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease [PDF]
, 2007 Aims: The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions.
A H Mustafa (16084112) +23 more
core +1 more source
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport
Frontiers in Cell and Developmental Biology, 2022 Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the ...
Sharon R. Garrott +4 more
doaj +1 more source
Regulation of chromosome congression : focus on the function of hSpindly and the kinetochore recruitment of the Ska complex [PDF]
, 2011 Mitosis is a process in which cells divide their genetic materials equally into two daughter cells. During mitosis, specialized structures called kinetochores (KTs), located at the centromeric regions of chromosomes, are captured by microtubules (MTs ...
Chan, Ying Wai
core +1 more source
A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
Nature Communications, 2020 Cytoplasmic dynein-1 (dynein) is the motor responsible for most retrograde transport of cargoes along microtubules in eukaryotic cells, including organelles, mRNA and viruses.
In-Gyun Lee +4 more
semanticscholar +1 more source
Force measurements with optical tweezers inside living cells [PDF]
, 2014 The force exerted by optical tweezers can be measured by tracking the momentum changes of the trapping beam, a method which is more general and powerful than traditional calibration techniques as it is based on first principles, but which has not been ...
Farre, A. +9 more
core +1 more source