Results 21 to 30 of about 266,976 (317)

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A [PDF]

, 2013
Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation
Erich A. Nigg, Francis A. Barr, Baron, Ryan D., Ricardo Nunes Bastos, Nunes Bastos, R, Ryan D. Baron, Nigg, EA, Gruneberg, Ulrike, Gandhi, Sapan R., Baron, RD, Barr, Francis, Gandhi, SR, Nunes Bastos, Ricardo, Ulrike Gruneberg, Nigg, Erich A., Sapan R. Gandhi, Barr, Francis A.   +16 more
core   +1 more source

A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation [PDF]

, 2014
The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is
Blanchard, Guy B., Adams, Richard J., Röper, Katja, Booth, Alexander J. R., Booth, Alexander J.R.   +4 more
core   +1 more source

Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics [PDF]

, 2014
EB1 is a conserved protein that plays a central role in regulating microtubule dynamics and organisation. It binds directly to microtubule plus ends and recruits other plus end localising proteins.
Warbrick, Emma, Ohkura, Hiroyuki, Lesniewska, Karolina   +2 more
core   +1 more source

A "MICROTUBULE" IN A BACTERIUM [PDF]

The Journal of Cell Biology, 1967
A study of the anchorage of the flagella in swarmers of Proteus mirabilis led to the incidental observation of microtubules. These microtubules were found in thin sections and in whole mount preparations of cells from which most of the content had been released by osmotic shock before staining negatively with potassium phosphotungstate (PTA).
W, van Iterson, J F, Hoeniger, E, Nijman van Zanten   +2 more
openaire   +2 more sources

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo [PDF]

, 2010
P. Martin and W. Wood contributed equally to this paperDrosophila melanogaster macrophages are highly migratory cells that lend themselves beautifully to high resolution in vivo imaging experiments.
Dunn, Graham, Martin, P., Martin Milner, Chieh-Yin Huang, Millard, T., Wood, Will, Millard, Tom, Dunn, G., Iwan Evans, Will Wood, Stramer, Brian, Tom Millard, Graham Dunn, Paul Martin, Severina Moreira, Wood, W., Huang, Chieh-Yin, Martin, Paul, Sabet, O., Moreira, S., Milner, M., Huang, C.Y., Huang, Chieh Yin, Brian Stramer, Moreira, Severina, Evans, Iwan, Milner, Martin John, Milner, Martin, Ola Sabet, Sabet, Ola, Evans, I., Stramer, B.   +31 more
core   +1 more source

A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome

eLife, 2019
The centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM).
Jérémy Magescas, Jenny C Zonka, Jessica L Feldman   +2 more
doaj   +1 more source

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]

, 2014
BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Sílvia Vieira, Wittmann, Torsten, Sousa, Mónica M., Márcia A Liz, Pimentel, Helena I., Vera F Sousa, Telma E Santos, Vieira, Sílvia, Marques, Ana M., Sutherland, Calum; id_orcid, Hayley Pemble, Liz, Márcia A., Calum Sutherland, Mar, Fernando M., Mónica M Sousa, Pemble, Hayley, Sousa, Vera F., Helena I Pimentel, James R Woodgett, Morgado, Marlene M., Torsten Wittmann, Woodgett, James R., Santos, Telma E., Fernando M Mar, Ana M Marques, Marlene M Morgado   +25 more
core   +1 more source

WDR47 protects neuronal microtubule minus ends from katanin-mediated severing

Cell Reports, 2021
Summary: Axons and dendrites are long extensions of neurons that contain arrays of noncentrosomal microtubules. Calmodulin-regulated spectrin-associated proteins (CAMSAPs) bind to and stabilize free microtubule minus ends and are critical for proper ...
Robin R. Buijs, Jessica J.A. Hummel, Mithila Burute, Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Maarten Altelaar, Anna Akhmanova, Lukas C. Kapitein, Casper C. Hoogenraad   +9 more
doaj   +1 more source

Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs [PDF]

, 2000
The surface topography of opened-up microtubule walls (sheets) decorated with monomeric and dimeric kinesin motor domains was investigated by freeze-drying and unidirectional metal shadowing.
Mandelkow, Eckhard, Song, Young Hwa, Woehlke, Guenther, Tittmann, Peter, Hoenger, Andreas, Gross, Heinz, Doerhoefer, Monika   +6 more
core   +1 more source

A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission

mBio, 2023
Mature gametocytes of Plasmodium falciparum display a banana (falciform) shape conferred by a complex array of subpellicular microtubules (SPMT) associated with the inner membrane complex (IMC).
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger   +10 more
doaj   +1 more source