Results 21 to 30 of about 289,777 (310)

Autoregulatory control of microtubule binding in doublecortin-like kinase 1

eLife, 2021
The microtubule-associated protein, doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and is a prominent therapeutic target for kinase inhibitors. The physiological roles of DCLK1 kinase activity and how it is regulated remain
Regina L Agulto, Melissa M Rogers, Tracy C Tan, Amrita Ramkumar, Ashlyn M Downing, Hannah Bodin, Julia Castro, Dan W Nowakowski, Kassandra M Ori-McKenney   +8 more
doaj   +1 more source

Actin–microtubule coordination at growing microtubule ends [PDF]

Nature Communications, 2014
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood.
Preciado López, Magdalena, Huber, Florian, Grigoriev, Ilya, Steinmetz, Michel O., Akhmanova, Anna, Koenderink, Gijsje H., Dogterom, Marileen   +6 more
openaire   +8 more sources

A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation [PDF]

, 2014
The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is
Blanchard, Guy B., Adams, Richard J., Röper, Katja, Booth, Alexander J. R.   +3 more
core   +1 more source

Regulation of cell migration by dynamic microtubules [PDF]

, 2011
Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility.
Irina Kaverina, Anne Straube, Kaverina, Irina, Straube, Anne   +3 more
core   +1 more source

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo [PDF]

, 2010
P. Martin and W. Wood contributed equally to this paperDrosophila melanogaster macrophages are highly migratory cells that lend themselves beautifully to high resolution in vivo imaging experiments.
Dunn, Graham, Martin, P., Martin Milner, Chieh-Yin Huang, Millard, T., Wood, Will, Millard, Tom, Dunn, G., Iwan Evans, Will Wood, Stramer, Brian, Tom Millard, Graham Dunn, Paul Martin, Severina Moreira, Wood, W., Huang, Chieh-Yin, Martin, Paul, Sabet, O., Moreira, S., Milner, M., Huang, C.Y., Huang, Chieh Yin, Brian Stramer, Moreira, Severina, Evans, Iwan, Milner, Martin John, Milner, Martin, Ola Sabet, Sabet, Ola, Evans, I., Stramer, B.   +31 more
core   +1 more source

Photocontrolling Microtubule Dynamics with Photoswitchable Chemical Reagents [PDF]

, 2021
Microtubule dynamics can be inhibited with sub-second temporal resolution and cellular-scale spatial resolution, by using precise illuminations to optically pattern where and when photoswitchable microtubule-inhibiting chemical reagents exert their ...
Oliver, Thorn-Seshold, Joyce, Meiring
core   +1 more source

A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome

eLife, 2019
The centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM).
Jérémy Magescas, Jenny C Zonka, Jessica L Feldman   +2 more
doaj   +1 more source

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]

, 2014
BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Sílvia Vieira, Wittmann, Torsten, Sousa, Mónica M., Márcia A Liz, Pimentel, Helena I., Vera F Sousa, Telma E Santos, Vieira, Sílvia, Marques, Ana M., Sutherland, Calum; id_orcid, Hayley Pemble, Liz, Márcia A., Calum Sutherland, Mar, Fernando M., Mónica M Sousa, Pemble, Hayley, Sousa, Vera F., Helena I Pimentel, James R Woodgett, Morgado, Marlene M., Torsten Wittmann, Woodgett, James R., Santos, Telma E., Fernando M Mar, Ana M Marques, Marlene M Morgado, Sousa, Mónica M, Marques, Ana M, Sutherland, Calum, Morgado, Marlene M, Pimentel, Helena I, Liz, Márcia A, Sousa, Vera F, Woodgett, James R, Mar, Fernando M, Santos, Telma E   +35 more
core   +1 more source

Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics [PDF]

, 2014
EB1 is a conserved protein that plays a central role in regulating microtubule dynamics and organisation. It binds directly to microtubule plus ends and recruits other plus end localising proteins.
Warbrick, Emma, Ohkura, Hiroyuki, Lesniewska, Karolina   +2 more
core   +1 more source

WDR47 protects neuronal microtubule minus ends from katanin-mediated severing

Cell Reports, 2021
Summary: Axons and dendrites are long extensions of neurons that contain arrays of noncentrosomal microtubules. Calmodulin-regulated spectrin-associated proteins (CAMSAPs) bind to and stabilize free microtubule minus ends and are critical for proper ...
Robin R. Buijs, Jessica J.A. Hummel, Mithila Burute, Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Maarten Altelaar, Anna Akhmanova, Lukas C. Kapitein, Casper C. Hoogenraad   +9 more
doaj   +1 more source