Results 11 to 20 of about 223,853 (265)

O‐GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype

Advanced Science, 2023
O‐GlcNAcylation functions as a cellular nutrient and stress sensor and participates in almost all cellular processes. However, it remains unclear whether O‐GlcNAcylation plays a role in the establishment and maintenance of cell polarity, because mice ...
Fan Yu, Song Yang, Hua Ni, Dai Heng, Xuemei Wu, Mulin Yang, Xinming Zhang, Yuxin Cao, Yandong Pei, Di An, Dengwen Li, Dayong Liu, Lin Liu, Leiting Pan, Quan Chen, Xueliang Zhu, Jun Zhou   +16 more
doaj   +1 more source

Tubulin Post-translational Modifications: Potential Therapeutic Approaches to Heart Failure

Frontiers in Cell and Developmental Biology, 2022
In recent decades, advancing insights into the mechanisms of cardiac dysfunction have focused on the involvement of microtubule network. A variety of tubulin post-translational modifications have been discovered to fine-tune the microtubules’ properties ...
Chang Liu, Yuwen Chen, Yao Xie, Meixiang Xiang   +3 more
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Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity

eLife, 2020
The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is
Liu He, Robbelien Kooistra, Ravi Das, Ellen Oudejans, Eric van Leen, Johannes Ziegler, Sybren Portegies, Bart de Haan, Anna van Regteren Altena, Riccardo Stucchi, AF Maarten Altelaar, Stefan Wieser, Michael Krieg, Casper C Hoogenraad, Martin Harterink   +14 more
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Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport

Frontiers in Cell and Developmental Biology, 2022
Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the ...
Sharon R. Garrott, Sharon R. Garrott, John P. Gillies, Morgan E. DeSantis, Morgan E. DeSantis   +4 more
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Self-assembly of pericentriolar material in interphase cells lacking centrioles

eLife, 2022
The major microtubule-organizing center (MTOC) in animal cells, the centrosome, comprises a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and anchors microtubules. Centrosome assembly depends on PCM binding to centrioles,
Fangrui Chen, Jingchao Wu, Malina K Iwanski, Daphne Jurriens, Arianna Sandron, Milena Pasolli, Gianmarco Puma, Jannes Z Kromhout, Chao Yang, Wilco Nijenhuis, Lukas C Kapitein, Florian Berger, Anna Akhmanova   +12 more
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Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

Molecules, 2016
While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules.
Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry   +7 more
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Transforming growth factor-β2 induces morphological alteration of human corneal endothelial cells in vitro [PDF]

International Journal of Ophthalmology, 2014
AIM:To investigate the morphological altering effect of transforming growth factor-β2 (TGF-β2) on untransfected human corneal endothelial cells (HCECs) in vitro.METHODS: After untransfected HCECs were treated with TGF-β2 at different concentrations, the ...
Jing Wang, Ting-Jun Fan, Xiu-Xia Yang, Shi-Min Chang   +3 more
doaj   +1 more source

Micron-scale geometrical features of microtubules as regulators of microtubule organization

eLife, 2021
The organization of micron-sized, multi-microtubule arrays from individual microtubules is essential for diverse cellular functions. The microtubule polymer is largely viewed as a passive building block during the organization process.
Nandini Mani, Sithara S Wijeratne, Radhika Subramanian   +2 more
doaj   +1 more source

Autoregulatory control of microtubule binding in doublecortin-like kinase 1

eLife, 2021
The microtubule-associated protein, doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and is a prominent therapeutic target for kinase inhibitors. The physiological roles of DCLK1 kinase activity and how it is regulated remain
Regina L Agulto, Melissa M Rogers, Tracy C Tan, Amrita Ramkumar, Ashlyn M Downing, Hannah Bodin, Julia Castro, Dan W Nowakowski, Kassandra M Ori-McKenney   +8 more
doaj   +1 more source

A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome

eLife, 2019
The centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM).
Jérémy Magescas, Jenny C Zonka, Jessica L Feldman   +2 more
doaj   +1 more source