Results 41 to 50 of about 266,976 (317)

Regulation of cell migration by dynamic microtubules [PDF]

, 2011
Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility.
Irina Kaverina, Anne Straube, Kaverina, Irina, Straube, Anne   +3 more
core   +1 more source

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases [PDF]

, 2010
During mitosis in most eukaryotic cells, chromosomes align and form a metaphase plate halfway between the spindle poles, about which they exhibit oscillatory movement. These movements are accompanied by changes in the distance between sister kinetochores,
Porter, Iain M.; id_orcid, McClelland, Sarah E., King, E. M., Toso, Alberto, Swedlow, Jason, Swedlow, Jason R.; id_orcid, McClelland, S. E., Meraldi, P., Gaudenz Danuser, McAinsh, Andrew D., Posch, Markus, Emma M. King, Dorn, J. F., King, Emma M., Andrew D. McAinsh, Winter, J. R., Iain M. Porter, Khuloud Jaqaman, Ana C. Amaro, Mchedlishvili, N., Dorn, Jonas F., Toso, A., Porter, I. M., Posch, M., Winter, Jennifer R., Jonas F. Dorn, Jason R. Swedlow, Jaqaman, Khuloud, Jennifer R. Winter, Sarah E. McClelland, Jaqaman, K., Amaro, Ana C., Danuser, Gaudenz, Porter, Iain M., Danuser, G., Markus Posch, Elliott, Hunter L., Swedlow, Jason R., Amaro, A. C., Nunu Mchedlishvili, Alberto Toso, Hunter L. Elliott, Patrick Meraldi, Mchedlishvili, Nunu, Meraldi, Patrick   +44 more
core   +1 more source

Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells

Molecules, 2020
Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division.
Filip Borys, Ewa Joachimiak, Hanna Krawczyk, Hanna Fabczak   +3 more
doaj   +1 more source

Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B-Lymphoma Cells through Tunnelling Nanotubes

Cells
Membrane nanotubes (NTs) are dynamic communication channels connecting spatially separated cells even over long distances and promoting the transport of different cellular cargos.
Henriett Halász, Viktória Tárnai, János Matkó, Miklós Nyitrai, Edina Szabó-Meleg   +4 more
doaj   +1 more source

The Tubulin Code in Mitosis and Cancer

Cells, 2020
The “tubulin code” combines different α/β-tubulin isotypes with several post-translational modifications (PTMs) to generate microtubule diversity in cells.
Danilo Lopes, Helder Maiato
doaj   +1 more source

The kinesin-12 Kif15 is a processive track-switching tetramer [PDF]

, 2014
Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement.
McHugh, Toni, Singleton, Martin R., Carter, Nicholas J., Toni McHugh, Hauke Drechsler, Nicholas J Carter, Drechsler, Hauke, McAinsh, Andrew D., Martin R Singleton, Andrew D McAinsh   +9 more
core   +1 more source

MAP2 phosphorylation: mechanisms, functional consequences, and emerging insights

Frontiers in Cellular Neuroscience
Microtubule-associated protein 2 (MAP2) is a key regulator of cytoskeletal dynamics and neuronal function. It stabilizes microtubules, shapes dendrites, influences synaptic plasticity, and regulates transportation and protein synthesis through its ...
Jiali Lyu, Jiali Lyu, Andrew G. DeMarco, Robert A. Sweet, Robert A. Sweet, Robert A. Sweet, Melanie J. Grubisha, Melanie J. Grubisha   +7 more
doaj   +1 more source

The polar code for patterning: how polarity and the cytoskeleton orchestrate asymmetric cell division during plant development

Frontiers in Cell and Developmental Biology
Cell polarity is fundamental to morphogenesis across living organisms. In plants, a dynamic interplay between polarity cues and the cytoskeleton orchestrates essential asymmetric cell divisions across diverse species.
Akanksha Garhewal, Gabriel J. Angres, Andrew Muroyama   +2 more
doaj   +1 more source

Dermal Fibroblast Migration and Proliferation Upon Wounding or Lipopolysaccharide Exposure is Mediated by Stathmin

Frontiers in Pharmacology, 2022
The dermal fibroblast is a crucial executor involved in wound healing, and lipopolysaccharide is a key factor in initiating the migration and proliferation of the dermal fibroblasts, followed by wound healing.
Ruiyan Cen, Liqun Wang, Yongqing He, Chenda Yue, Yang Tan, Lingfei Li, Xia Lei   +6 more
doaj   +1 more source

Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis [PDF]

, 2010
We have studied Sds22, a conserved regulator of protein phosphatase 1 (PP1) activity, and determined its role in modulating the activity of aurora B kinase and kinetochore-microtubule inter-actions.
DeLuca, Jennifer G., Khoudoli, Guennadi A., Guennadi A. Khoudoli, Jennifer G. DeLuca, Jason R. Swedlow, Markus Posch, Swedlow, Jason R.; id_orcid, Swift, Sam, Posch, Markus, Emma M. King, King, Emma M., Sam Swift   +11 more
core   +1 more source