Combinatorial chemistry in drug discovery. [PDF]
Curr Opin Chem Biol, 2017 Several combinatorial methods have been developed to create focused or diverse chemical libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non-peptide oligomers, peptidomimetics, small-molecules, and natural product-like ...
Liu R, Li X, Lam KS.
europepmc +2 more sources
The dark side of disulfide-based dynamic combinatorial chemistry. [PDF]
Chem Sci, 2020 International audienceDuring the last two decades, disulfide-based dynamic combinatorial chemistry has been extensively used in the field of molecular recognition to deliver artificial receptors for molecules of biological interest.
Dumartin M +7 more
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Discovery of antibacterial manganese(i) tricarbonyl complexes through combinatorial chemistry. [PDF]
Chem Sci: The continuous rise of antimicrobial resistance is a serious threat to human health and already causing hundreds of thousands of deaths each year. While natural products and synthetic organic small molecules have provided the majority of our current ...
Scaccaglia M +4 more
europepmc +2 more sources
Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]
, 2013 Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Otto, Sijbren, +9 more
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AlgM4: A New Salt-Activated Alginate Lyase of the PL7 Family with Endolytic Activity
Marine Drugs, 2018 Alginate lyases are a group of enzymes that catalyze the depolymerization of alginates into oligosaccharides or monosaccharides. These enzymes have been widely used for a variety of purposes, such as producing bioactive oligosaccharides, controlling the ...
Guiyuan Huang +7 more
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Dynamic combinatorial libraries: new opportunities in systems chemistry [PDF]
, 2011 Combinatorial chemistry is a tool for selecting molecules with special properties. Dynamic combinatorial chemistry started off aiming to be just that.
Hunt, Rosemary A.R. +3 more
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A semantic datagrid for combinatorial chemistry [PDF]
The 6th IEEE/ACM International Workshop on Grid Computing, 2005., 2005 The CombeChem project has designed and deployed an e-science infrastructure using a combination of grid and semantic Web technologies. In this paper we describe the datagrid element of the project, which provides a platform for sophisticated scientific queries and a rich record of experimental data and its provenance.
Kieron R. Taylor +5 more
openaire +2 more sources
Discovery of Antibacterial Manganese(I) Tricarbonyl Complexes through Combinatorial Chemistry
, 2023 The continuous rise of antimicrobial resistance is a serious threat to human health and already causing hundreds of thousands of deaths each year. While natural products and synthetic organic small molecules have provided the majority of our current ...
Giorgio, Pelosi +3 more
core +1 more source
Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment
Advanced Science, 2022 Smart nanomaterials constitute a new approach toward safer and more effective combined anti‐cancer immunotherapy. In this study, polydopamine‐multiprotein conjugates (DmPCs) that can be used for targeted delivery of multiple proteins to cells, realize ...
Xuemei Wang +5 more
doaj +1 more source
Development of Advanced Macrosphelides: Potent Anticancer Agents
Molecules, 2015 Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
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