Results 31 to 40 of about 2,494,908 (263)

Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment

Advanced Science, 2022
Smart nanomaterials constitute a new approach toward safer and more effective combined anti‐cancer immunotherapy. In this study, polydopamine‐multiprotein conjugates (DmPCs) that can be used for targeted delivery of multiple proteins to cells, realize ...
Xuemei Wang, Shengbo Li, Siqi Wang, Shuo Zheng, Zhenbing Chen, Heng Song   +5 more
doaj   +1 more source

The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

Acta Chimica Slovenica, 2017
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj   +1 more source

An overview of the cycloaddition chemistry of fulvenes and emerging applications

Beilstein Journal of Organic Chemistry, 2019
The unusual electronic properties and unique reactivity of fulvenes have interested researchers for over a century. The propensity to form dipolar structures at relatively low temperatures and to participate as various components in cycloaddition ...
Ellen Swan, Kirsten Platts, Anton Blencowe   +2 more
doaj   +1 more source

Stability Evaluation and Degradation Studies of DAC^® Hyaluronic-Polylactide Based Hydrogel by DOSY NMR Spectroscopy

Biomolecules, 2020
The stability and the degradation of polymers in physiological conditions are very important issues in biomedical applications. The copolymer of hyaluronic acid and poly-D,L-lactic acid (made available in a product called DAC®) produces a hydrogel which ...
Tatiana Guzzo, Fabio Barile, Cecilia Marras, Davide Bellini, Walter Mandaliti, Ridvan Nepravishta, Maurizio Paci, Alessandra Topai   +7 more
doaj   +1 more source

Protein-directed dynamic combinatorial chemistry [PDF]

, 2011
Dynamic combinatorial chemistry (DCC) is a novel approach to medicinal chemistry which integrates the synthesis and screening of small molecule libraries into a single step.
Bhat, Venugopal T.
core   +3 more sources

Dynamic combinatorial libraries: new opportunities in systems chemistry [PDF]

, 2011
Combinatorial chemistry is a tool for selecting molecules with special properties. Dynamic combinatorial chemistry started off aiming to be just that.
Hunt, Rosemary A.R., Otto, Sijbren; id_orcid, Hunt, Rosemary A. R., Otto, Sijbren   +3 more
core   +1 more source

Combinatorial representations [PDF]

, 2011
23pp. Submitted to J. Combinatorial Theory (Series A)arXiv:1109.1216v1 [math.CO]23pp. Submitted to J. Combinatorial Theory (Series A)23pp. Submitted to J.
Maximilien Gadouleau, Cameron, PJ, Gadouleau, M, Riis, S, Cameron, Peter J., Riis, Soren, Gadouleau, Maximilien, Cameron, Peter Jephson, Riis, Søren, Søren Riis, Peter J. Cameron   +10 more
core   +1 more source

Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production

, 2012
10.1021/co300007aACS Combinatorial Science147395 ...
Kim, Jaoon Y. H., Lee, Y., Chang, Young-Tae, Ha, H.-H., Lee, Woo Sirl, Lee, J.W., Chang, Y.-T., Bork, J.T., Lee, W.S., Vendrell, M., Ha, Hyung-Ho, Kim, J.Y.H., Lee, Y, Bork, Jacqueline T., Lee, Jae Wook, Vendrell, Marc   +15 more
core   +1 more source

Sobre o uso de métodos quimiométricos em química combinatória The use of chemometric methods on combinatorial chemistry

Química Nova, 2000
Combinatorial chemistry has emerged as a tool to circumvent a major problem of pharmaceutical industries to discover new lead compounds. A rapid and massive evaluation of a myriad of newly synthesised compounds can be carried out. Combinatorial synthesis
Andrei Leitão, Carlos A. Montanari, Claudio L. Donnici   +2 more
doaj   +1 more source

Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases

Nature Communications, 2020
Terpene cyclases catalyze the formation of diverse hydrocarbon scaffolds found in terpenoids. Here, the authors report the cryptic function of class I terpene cyclases as aromatic prenyltransferases and the universality of this cryptic feature is ...
Haibing He, Guangkai Bian, Corey J. Herbst-Gervasoni, Takahiro Mori, Stephen A. Shinsky, Anwei Hou, Xin Mu, Minjian Huang, Shu Cheng, Zixin Deng, David W. Christianson, Ikuro Abe, Tiangang Liu   +12 more
doaj   +1 more source