Results 51 to 60 of about 2,494,908 (263)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Novel Affinity Ligands for Chromatography Using Combinatorial Chemistry

, 2011
Spatially addressable combinatorial libraries were synthesized by solution phase chemistry and screened for binding to human serum albumin. Members of arylidene diamide libraries were among the best hits found, having submicromolar binding affinities ...
Gallion, SL, Eckersten, A, Joseph C. Hogan, Eckersten, Ann, Fagerstam, L, Lindquist, C,, Hogan, JCJ, Yasuro Shinohara, Charlotta Lindquist, Ellström, Christel, Lars Fagerstam, Pilotti, Åke,, Shinohara, Y, Regberg, T, Ake Pilotti, Ann Eckersten, Ellstrom, C, Regberg, Tor, Christel Ellstrom, Steven L. Gallion, Tor Regberg, Lindquist, Charlotta,, Hogan, Joseph C., Jr., Fagerstam, Lars, Shinohara, Yasuro, Gallion, Steven L., Pilotti, A   +26 more
core   +1 more source

The synthesis of a small library of prospective growth hormone secretagogues [PDF]

Journal of the Serbian Chemical Society, 1999
Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues.
Pejović Vojislav, Šoškić Vukić, Joksimović Jelena   +2 more
doaj   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Combinatorial Regression for Analytical Chemistry

International Journal of Analytical Chemistry
A current problem in analytical chemistry is to match the uncertainty of several independent sample replicates with the measurement uncertainty associated with first-order models.
Jens E. T. Andersen
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Química combinatória de materiais com análise por microdifração de raios X. Primeira parte: fundamentos Combinatorial chemistry of materials with analysis by X-ray microdiffraction. Part I: fundamentals

Química Nova, 2005
Combinatorial chemistry refers to techniques to rapidly fabricate tens, hundreds or even thousands of different micro samples. The analysis of the large number of samples generated by combinatorial methods requires highly efficient analytical methods. In
Najla Maroun Estrada, Francisco Manoel dos Santos Garrido, Marta Eloisa Medeiros, Sérgio de Paula Machado   +3 more
doaj   +1 more source