Results 61 to 70 of about 42,234 (281)

Protein-directed dynamic combinatorial chemistry [PDF]

, 2011
Dynamic combinatorial chemistry (DCC) is a novel approach to medicinal chemistry which integrates the synthesis and screening of small molecule libraries into a single step.
Bhat, Venugopal T.
core  

Design, Synthesis, and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1,2,3,4-tetrahydroisoquinoline and 1-Oxo-1,2-dihydroisoquinoline Scaffolds [PDF]

, 2010
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher.
R. Padmanabhan, Dengfeng Dou, Padmanabhan, Radhakrishnan, Groutas, William C., Kevin R. Alliston, William C. Groutas, Prasanth Viwanathan, Dou, Dengfeng, Li, Yi, Alliston, Kevin R., Brown-Clay, Joshua D., Lushington, Gerald H., He, Guijia, Yi Li, Gerald H. Lushington, Viwanathan, Prasanth, Joshua D. Brown-Clay, Guijia He   +17 more
core   +1 more source

Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

Nature Communications, 2018
The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which
Wenya Tian, Chenghai Sun, Mei Zheng, Jeffrey R. Harmer, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Zixin Deng, Shi-Lu Chen, Mehdi Mobli, Xinying Jia, Xudong Qu   +12 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Citrus-Based Bio-Insect Repellents—A Review on Historical and Emerging Trends in Utilizing Phytochemicals of Citrus Plants

Journal of Toxicology
Research on citrus plants is the result of increasing interest in the discovery of plant species with potential insect-repellent properties. Insect-repelling ability can be achieved by the numerous ubiquitous citrus species.
S. S. S. T. Fernando, R. G. P. T. Jayasooriya, Kalpa W. Samarakoon, N. D. Asha D. Wijegunawardana, Sampath B. Alahakoon   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Infinite products over visible lattice points

International Journal of Mathematics and Mathematical Sciences, 1994
About fifty new multivariate combinatorial identities are given, connected with partition theory, prime products, and Dirichlet series. Connections to Lattice Sums in Chemistry and Physics are alluded to also.
Geoffrey B. Campbell
doaj   +1 more source

Library Design

CHIMIA, 2003
This review aims at giving a short introduction to the most important areas of library design. The description of compounds by descriptors and fingerprints, and similarity-based clustering techniques are illustrated in the context of untargeted ...
Friederike Stoll
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source