Results 41 to 50 of about 2,494,908 (263)
Introduction to combinatorial chemistry and technologies : principles and methods
, 2007 An introduction to the huse of high throughput technologies (HTS, combinatorial chemistry, virtual screening, etc) in various areas was presented and ...
Pierfausto Seneci
core +2 more sources
Dynamic combinatorial libraries of complexes with oligopyridine ligands [PDF]
, 2006 Chapter 1 gives a background of some achievements reached in the fields of dynamic combinatorial libraries, 2,2´-bipyridine and 2,2´:6´,2´´-terpyridine chemistry, and ferrocenes compounds in the years preceding the present work.
Brisig, Barbara
core +1 more source
Química Nova, 2001 Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead ...
Ricardo L. Araújo Dias +1 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Synthesis of Novel 2-(Pyridin-2-yl) Pyrimidine Derivatives and Study of Their Anti-Fibrosis Activity
Molecules, 2020 A pyrimidine moiety exhibiting a wide range of pharmacological activities has been employed in the design of privileged structures in medicinal chemistry. To prepare libraries of novel heterocyclic compounds with potential biological activities, a series
Yi-Fei Gu +6 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Towards the Development of Sequence-Selective Artificial Proteases
CHIMIA, 1999 The development of artificial sequence-selective proteolytic metal complexes is endeavoured by use of encoded combinatorial chemistry.
Helma Wennemers
doaj +1 more source
eLife, 2021 ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases.
Erich Stefan +7 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Cathelicidins - Nature's attempt at combinatorial chemistry
, 2005 Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments.
Borregaard, N +2 more
core +1 more source