Results 41 to 50 of about 42,234 (281)

Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG

, 2004
10.1021/cc049900sJournal of Combinatorial Chemistry66862 ...
Walsh, D.P., Khersonsky, S.M., Uttamchandani, M, Chang, Young-Tae, Huang, X, Walsh, DP, Uttamchandani, M., Yao, SQ, Khersonsky, SM, Huang, X., Yao, S.Q., Chang, Y.-T.   +11 more
core   +1 more source

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

eLife, 2021
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases.
Erich Stefan, Richard Obexer, Susanne Hofmann, Khanh Vu Huu, Yichao Huang, Nina Morgner, Hiroaki Suga, Robert Tampé   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Pyrroloindole-Based Dynamic Combinatorial Chemistry

, 2020
We report a new class of building blocks for Dynamic Combinatorial Chemistry (DCC) based on the pyrroloindole scaffold. The attachment of l-cysteine on the α, α′ positions of the core makes the molecule suitable for disulfide exchange ...
Tiberiu-Marius Gianga, G. Dan Pantoș, Dora-Maria Răsădean   +2 more
core   +1 more source

Combinatorial Regression for Analytical Chemistry

International Journal of Analytical Chemistry
A current problem in analytical chemistry is to match the uncertainty of several independent sample replicates with the measurement uncertainty associated with first-order models.
Jens E. T. Andersen
doaj   +1 more source

Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry. [PDF]

Org Biomol Chem
The molecular recognition of saccharides by synthetic hosts has become an appealing but elusive task in the last decades. Herein, we combine Dynamic Combinatorial Chemistry (DCC) for the rapid self-assembly and screening of virtual libraries of receptors,
Alena-Rodriguez M, Fernandez-Villamarin M, Alfonso I, Mendes PM.   +3 more
europepmc   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Target-directed dynamic combinatorial chemistry affords inhibitors of Nsp10 as potential antivirals against SARS-CoV-2

, 2023
The development of antiviral drugs against the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) responsible for the recent worldwide Covid-19 pandemic is important, as treatment options are still very limited and vaccination largely does not ...
Sebastian, Adam, Rute G., Matos, Anna K. H., Hirsch, Rolf, Müller, Cecilia M., Arraiano, Marta V., Cunha, Antonia P., Gunesch, Margarida, Saramago, Natalie M., Köhler, Sandra, Johannsen, Ravindra P., Jumde, Gwenaëlle, Jézéquel, Thomas, Pietschmann, Nicolas, Frank, Chantal, Bader   +14 more
core   +1 more source

Química combinatória de materiais com análise por microdifração de raios X. Primeira parte: fundamentos Combinatorial chemistry of materials with analysis by X-ray microdiffraction. Part I: fundamentals

Química Nova, 2005
Combinatorial chemistry refers to techniques to rapidly fabricate tens, hundreds or even thousands of different micro samples. The analysis of the large number of samples generated by combinatorial methods requires highly efficient analytical methods. In
Najla Maroun Estrada, Francisco Manoel dos Santos Garrido, Marta Eloisa Medeiros, Sérgio de Paula Machado   +3 more
doaj   +1 more source