Results 71 to 80 of about 117,682 (268)

Hydrogen bond network topology in liquid water and methanol: a graph theory approach [PDF]

, 2013
Networks are increasingly recognized as important building blocks of various systems in nature and society. Water is known to possess an extended hydrogen bond network, in which the individual bonds are broken in the sub-picosecond range and still the ...
Abascal, Albert, Bako, Bakó, Barabási, Barahona, Berendsen, Blumberg, Boccaletti, Chihaia, Chung, da Silva, da Silva, Dorogovtsev, Dorogovtsev, dos Santos, Erdős, Erdős, Errington, Errington, Farkas, Fiedler, Forster, Geiger, Gómez-Álvarez, Holzmann, Imre Bakó, Jan, Jeong, Jorgensen, Julianna Oláh, Kersti Hermannson, Kim, Kim, Kiss, Kiss, Kuhn, Kumar, Kumar, Lehota, Luzar, Luzar, Ma, Matsumoto, Matsumoto, Mcgraw, Megyes, Mitrowic, Mura, Newmann, Oleinikova, Onnela, Pálinkás, Samuhkin, Schmidt, Schmidt, Sciortiono, Stanley, Stanley, Szabolcs Bálint, Tamás Grósz, Timothy, Viorel Chihaia, Vrhovsek, Watts, Wigner, Wigner, Wigner, Ákos Bencsura   +68 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Combinatorial Chemistry [PDF]

Drug Discovery Today, 2002
Morten Meldal, Michael Pirrung
  +6 more sources

Infinite products over visible lattice points

International Journal of Mathematics and Mathematical Sciences, 1994
About fifty new multivariate combinatorial identities are given, connected with partition theory, prime products, and Dirichlet series. Connections to Lattice Sums in Chemistry and Physics are alluded to also.
Geoffrey B. Campbell
doaj   +1 more source

Library Design

CHIMIA, 2003
This review aims at giving a short introduction to the most important areas of library design. The description of compounds by descriptors and fingerprints, and similarity-based clustering techniques are illustrated in the context of untargeted ...
Friederike Stoll
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents

Molecules, 2011
We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CNS agents. Herein, we demonstrate, for the first time, student engagement from different sites around the globe in the development of new biologically ...
William L. Scott, Ziniu Zhou, Martin J. O’Donnell, Grzegorz Satała, Andrzej J. Bojarski, Jean Martinez, Gaël Nomezine, Maciej Pawłowski, Gilles Subra, Katarzyna Grychowska, Joanna Król, Paweł Zajdel   +11 more
doaj   +1 more source

Xanthines as a scaffold for molecular diversity [PDF]

, 2018
Summary: Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring ...
Eberle, Alex, Heizmann, Gerhard
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source