Results 91 to 100 of about 42,234 (281)

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium Tuberculosis IspE

In the search for new antitubercular compounds, we leveraged target-directed dynamic combinatorial chemistry (tdDCC) as an efficient hit-identification method.
Andreas M., Kany, Anna K. H., Hirsch, Jörg, Haupenthal, Eleonora, Diamanti, Norbert, Reiling, Maria, Braun-Cornejo, Vidhisha, Sonawane, Gwenaëlle, Jézéquel, Wulf, Blankenfeldt, Peter, Maas, Camilla, Ornago   +10 more
core   +1 more source

Dynamic combinatorial chemistry at the phospholipid bilayer interface

, 2010
Background: Molecular recognition at the environment provided by the phospholipid bilayer interface plays an important role in biology and is subject of intense investigation. Dynamic combinatorial chemistry is a powerful approach for exploring molecular
Otto, Sijbren,, Otto, Sijbren; id_orcid, Au-Yeung, Ho Yu,, Friederike M Mansfeld, Sijbren Otto, Sanders, Jeremy K.M.,, Sanders, Jeremy K.M., Mansfeld, Friederike M.,, Jeremy KM Sanders, Mansfeld, Friederike M., Au-Yeung, Ho Yu, Otto, Sijbren, Ho Yu Au-Yeung   +12 more
core   +1 more source

Combinatorial Chemistry Approach To Development Of Molecular Plastic Solar Cells [PDF]

, 1999
We used a combinatorial chemistry approach to develop the molecular plastic solar cells based on soluble fullerene derivatives or solubilized TCNQ molecules in combination with conjugated polymers.
Dmitri Godovsky, Sariciftci, N.S.,, Godovsky, D., M. Prato, Inganäs, Olle, Janssen, Rene A.J.,, Sariciftci, N. Serdar, Martin, Nazario,, Janssen, R.A.J.,, Maggini, M.,, M. Maggini, Hummelen, J.C., Segura, Jose, Hummelen, J.C.,, Rene A. J. Janssen, Sariciftci, N. Serdar,, Prato, M., Prato, M.,, Segura, J., Olle Inganäs, Inganäs, O.,, Brabec, C.J.,, J. C. HUMMELEN, C. J. BRABEC, PRATO, MAURIZIO, Sariciftci, N.S., Godovsky, D.,, Martin, N., Godovsky, Dmitri,, Janssen, Rene A.J., Inganäs, Olle,, Brabec, Christoph J., N. MARTIN, R. A. J. JANSSEN, Brabec, C.J., Godovsky, Dmitri, Segura, Jose,, MAGGINI, MICHELE, Martin, Nazario, D. GODOVSKY, Hummelen, Jan C., N. S. SARICIFTCI, O. INGANAS, Christoph J. Brabec, Jose Segura, Hummelen, Jan C.,, Inganäs, O., Janssen, R.A.J.; id_orcid, Nazario Martin, Jan C. Hummelen, Maggini, M., N. Serdar Sariciftci, Brabec, Christoph J.,, J. SEGURA   +53 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dynamic combinatorial chemistry with diselenides and disulfides in water

, 2014
Diselenide exchange is introduced as a reversible reaction in dynamic combinatorial chemistry in water. At neutral pH, diselenides are found to mix with disulfides and form dynamic combinatorial libraries of diselenides, disulfides, and selenenylsulfides.
Rasmussen, Brian, Pittelkow, Michael, Gotfredsen, Henrik, Sørensen, Anne   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives

Molecules, 2016
Benzoic acid and o-phenylenediamine efficiently reacted under the green solvent-free Ball Milling method. Several reaction parameters were investigated such as rotation frequency; milling balls weight and milling time.
Taghreed H. EL-Sayed, Asmaa Aboelnaga, Mohamed Hagar   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source