Results 111 to 120 of about 42,234 (281)

A Combinatorial Method for Discovery of BaTiO3-based Positive Temperature Coefficient Resistors

, 2010
PhDThe conventional materials discovery is a kind of empirical (“trial and error”) science that of handling one sample at a time in the processes of synthesis and characterization.
Chen, Yulong
core  

Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors. [PDF]

ACS Med Chem Lett, 2022
Wu Y, Liu C, Hu L.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry. [PDF]

ACS Med Chem Lett, 2022
Bagnolini G, Balboni B, Schipani F, Gioia D, Veronesi M, De Franco F, Kaya C, Jumde RP, Ortega JA, Girotto S, Hirsch AKH, Roberti M, Cavalli A.   +12 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin

, 2013
10.1021/co400060bACS Combinatorial Science159452 ...
Zhai, D., Er, J.C., Vendrell, M., Chang, Young-Tae, Tang, Mui Kee, Zhai, Duanting, Tang, M.K., Chang, Y.-T., Er, Jun Cheng, Vendrell, Marc   +9 more
core   +1 more source

Virtual Combinatorial Chemistry and Pharmacological Screening: A Short Guide to Drug Design. [PDF]

Int J Mol Sci, 2022
Suay-García B, Bueso-Bordils JI, Falcó A, Antón-Fos GM, Alemán-López PA.   +4 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Overview of Combinatorial Technologies in Modern Natural Products Research

, 2007
The use of high throughput technologies (HTS, combinatorial chemistry) to facilitate the discovery and structural optimization of natural products in South East Asian Countries, and particularly in Thailand, was discussed and ...
Pierfausto Seneci
core  

Recapture of GFP chromophore fluorescence in a protein host

, 2011
10.1021/co200025eACS Combinatorial Science133214 ...
Suihan Feng, Baldridge, Anthony, Chang, Young-Tae, Young-Tae Chang, Baldridge, A., Anthony Baldridge, Tolbert, Laren M., Feng, S., Tolbert, L.M., Chang, Y.-T., Feng, Suihan, Laren M. Tolbert   +11 more
core   +1 more source