Results 1 to 10 of about 155,115 (251)
Genetic Variation in Drug Targets: Are We Ready for the Era of Precision Medicinal Chemistry? [PDF]
ACS Med Chem LettVeale CGL, Edkins AL.
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Furazans in Medicinal Chemistry
Journal of Medicinal Chemistry, 2021Incorporation of heterocycles into drug molecules can enhance physical properties and biological activity. A variety of heterocyclic groups is available to medicinal chemists, many of which have been reviewed in detail elsewhere. Oxadiazoles are a class of heterocycle containing one oxygen and two nitrogen atoms, available in three isomeric forms ...
Ross S. Mancini +3 more
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Metallocyclodextrins in Medicinal Chemistry
Future Medicinal Chemistry, 2018This review focuses on metal complexes of cyclodextrin (CyD) derivatives designed for application as therapeutics or diagnostics. We discuss examples of metalloprotein models (hemoglobin, superoxide dismutase and catalase) based on cyclodextrins. The hydrophobic microenvironment of CyDs stabilizes the Fe(II) porphyrin system that can reversibly bind O2
Valentina Oliveri, Graziella Vecchio
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The Medicinal Chemistry of Caffeine
Journal of Medicinal Chemistry, 2021The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world and has multiple beneficial pharmacological activities, for example, in neurodegenerative diseases. However, despite being an extensively studied bioactive natural product, the mechanistic understanding of caffeine's pharmacological effects is incomplete.
Giuseppe Faudone +2 more
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Polyethylenimine In Medicinal Chemistry
Current Medicinal Chemistry, 2008Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal ...
VICENNATI, PAOLA +3 more
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Oxadiazoles in Medicinal Chemistry
Journal of Medicinal Chemistry, 2012Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities.
Jonas, Boström +4 more
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The Medicinal Chemistry of Peptides
Current Medicinal Chemistry, 2009The shortcomings of native peptides as pharmaceuticals have been long known: short duration of action, lack of receptor selectivity, lack of oral bioavailability. However medicinal chemistry offers solutions to the first two limitations and oral bioavailability issues have been addressed with novel routes of administration (e.g. intranasal, inhalation)
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Medicinal Chemistry of Aminocyclitols
Current Medicinal Chemistry, 2010Aminocyclitols comprise an important group of compounds with remarkable biological activities. From a structural standpoint, aminocyclitols are amino polyhydroxy cycloalkanes that can be found in nature in several families of natural products. Among them, the aminoglycoside antibiotics, since the discovery of streptomycin, have become particularly ...
Díaz-Bueno, Lucía +1 more
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