Results 41 to 50 of about 3,137,400 (295)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Medicinal Chemistry Database GDBMedChem [PDF]

, 2019
The generated database GDB17 enumerates 166.4 billion possible molecules up to 17 atoms of C, N, O, S and halogens following simple chemical stability and synthetic feasibility rules, however medicinal chemistry criteria are not taken into account.
Finton, Sirockin, Nikolaus, Stiefl, Mahendra, Awale, Jean-Louis, Reymond   +3 more
core   +2 more sources

Anti-Cancer Agents in Medicinal Chemistry

, 2013
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
CAPRANICO, GIOVANNI
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors

, 2009
10.1016/j.bmcl.2009.02.004Bioorganic and Medicinal Chemistry Letters1961643 ...
Park, Jeong-Ju, Satoh, S., Li, Q., Chang, Young-Tae, Chung, SK, Igarashi, Y., Satoh, Shigeru, Chang, Y.-T., Murakami, I., Li, Qian, Murakami, Itsuo, Chung, S.-K., Park, J.-J., Mitsutake, Susumu, Igarashi, Yasuyuki, Mitsutake, S., Tsuji, Kiyomi, Tsuji, K.   +17 more
core   +1 more source

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs [PDF]

, 2009
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Rijt, Sabine H. van, Sadler, P. J.
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Women in Medicinal Chemistry Special Issue Call for Papers

, 2019
The Journal of Medicinal Chemistry will be publishing a special issue on “Women in Medicinal Chemistry” in March 2020 together with ACS Medicinal Chemistry Letters, publishing on the same topic.Full ...
Hong Liu, Ganamet, Kelly L, Wang, Shaomeng, Shaomeng Wang, Bolognesi, Maria Laura, Gunda I. Georg, Maria Laura Bolognesi, Sally-Ann Poulsen, Georg, Gunda I, Liu, Hong, Poulsen, Sally-Ann, Kelly L. Ganamet   +11 more
core   +1 more source

Information extraction in the life sciences: Perspectives for medicinal chemistry, pharmacology and toxicology

, 2022
S.785-796Information extraction approaches have been successfully applied to mine the scientific literature in biology and medicine. So far, the main focus of research and development in this domain was on the recognition and extraction of gene and ...
Zimmermann, M., Fluck, J., Hofmann, M., Thi, L.T.B., Kumpf, K., Kolarik, C.   +5 more
core   +1 more source